GO Annotations Graph

• Symbol: Six3
• Name: sine oculis-related homeobox 3
• ID: MGI:102764

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:77680
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:116102
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:123470
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:81797
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:116102
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:116102
Molecular Function	GO:0042826	histone deacetylase binding	IPI	J:123470
Molecular Function	GO:0005515	protein binding	IPI	J:212800
Molecular Function	GO:0005515	protein binding	IPI	J:123470
Molecular Function	GO:0005515	protein binding	IPI	J:103131
Molecular Function	GO:0005515	protein binding	IPI	J:77680
Molecular Function	GO:0005515	protein binding	IPI	J:77680
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:116102
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:73065
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:35368
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0001222	transcription corepressor binding	IPI	J:123470
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:103131
Cellular Component	GO:0005634	nucleus	IDA	J:35368
Cellular Component	GO:0005634	nucleus	IDA	J:77680
Cellular Component	GO:0005667	transcription regulator complex	IBA	J:265628
Biological Process	GO:1902742	apoptotic process involved in development	IMP	J:140315
Biological Process	GO:0007420	brain development	IBA	J:265628
Biological Process	GO:0007420	brain development	IMP	J:81797
Biological Process	GO:0043010	camera-type eye development	IGI	J:77351
Biological Process	GO:0021846	cell proliferation in forebrain	IMP	J:140315
Biological Process	GO:0048512	circadian behavior	IMP	J:171421
Biological Process	GO:0021536	diencephalon development	IGI	J:130851
Biological Process	GO:0002070	epithelial cell maturation	IMP	J:178674
Biological Process	GO:0001654	eye development	ISO	J:164563
Biological Process	GO:0001654	eye development	IBA	J:265628
Biological Process	GO:0001654	eye development	IDA	J:77680
Biological Process	GO:0021797	forebrain anterior/posterior pattern specification	IMP	J:130851
Biological Process	GO:0021797	forebrain anterior/posterior pattern specification	IGI	J:130851
Biological Process	GO:0021798	forebrain dorsal/ventral pattern formation	ISO	J:164563
Biological Process	GO:0008406	gonad development	IGI	J:142425
Biological Process	GO:0002088	lens development in camera-type eye	IDA	J:67049
Biological Process	GO:1990086	lens fiber cell apoptotic process	IDA	J:77351
Biological Process	GO:0070306	lens fiber cell differentiation	IDA	J:77351
Biological Process	GO:0060235	lens induction in camera-type eye	IMP	J:116102
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0035264	multicellular organism growth	IGI	J:142425
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:67049
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:77680
Biological Process	GO:0045665	negative regulation of neuron differentiation	IDA	J:212804
Biological Process	GO:0030178	negative regulation of Wnt signaling pathway	IMP	J:81797
Biological Process	GO:0014016	neuroblast differentiation	IMP	J:178674
Biological Process	GO:0097402	neuroblast migration	IMP	J:178674
Biological Process	GO:0003404	optic vesicle morphogenesis	IDA	J:70282
Biological Process	GO:0021983	pituitary gland development	IMP	J:142425
Biological Process	GO:0021983	pituitary gland development	IGI	J:142425
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:116102
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:116102
Biological Process	GO:0006606	protein import into nucleus	IDA	J:103131
Biological Process	GO:0009946	proximal/distal axis specification	IDA	J:212815
Biological Process	GO:1901987	regulation of cell cycle phase transition	IDA	J:212804
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:142425
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:2000177	regulation of neural precursor cell proliferation	IDA	J:212804
Biological Process	GO:0061074	regulation of neural retina development	IMP	J:165328
Biological Process	GO:1902692	regulation of neuroblast proliferation	IMP	J:178674
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0021537	telencephalon development	IMP	J:140315
Biological Process	GO:0021537	telencephalon development	IMP	J:130851
Biological Process	GO:0021978	telencephalon regionalization	IMP	J:140315
Biological Process	GO:0030878	thyroid gland development	IGI	J:142425