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Itga7
Gene Detail
 Symbol
Name
ID
Itga7
integrin alpha 7
MGI:102700
Synonyms [a]7, alpha7
Feature Type protein coding gene
Genetic Map
Chromosome 10
77.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:128933813-128958277 bp, + strand
From Ensembl annotation of GRCm38

  24465 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37592  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga7

Human
homologs
Human Homolog ITGA7, integrin, alpha 7
NCBI Gene ID 3679
neXtProt AC  NX_Q13683
Human Chr (Location)  12q13; chr12:55684568-55716037 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITGA7
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene display characteristics of muscular dystrophy.
 
Human Diseases Modeled Using Mouse Itga7 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process blood vessel morphogenesis, cell adhesion, ...
Component cell surface, cytoplasm, ...
Function cell adhesion molecule binding, integrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (237)    Tissues (126)    Images (50)
Theiler Stages: 4, 5, 8, 11, 13, 15, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 25
RNA in situ 144
RT-PCR 68
cDNA source data(50)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(62) Genomic(3) cDNA(53) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000025348 (Evidence)
Entrez Gene16404 (Evidence)
UniGene179747
DFCITC1579951, TC1644099
DoTSDT.40146185, DT.530750, DT.55277368
NIA Mouse Gene IndexU012206
Consensus CDS ProjectCCDS24300.1
International Mouse Knockout Project StatusItga7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025348 Ensembl Gene Model | MGI Sequence Detail 24465 C57BL/6J ±  kb
transcript ENSMUST00000099112 Ensembl | MGI Sequence Detail 4013 Not Applicable 
polypeptide ENSMUSP00000096712 Ensembl | MGI Sequence Detail 1136 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(257 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology PR:000009132 integrin alpha-7
References (Earliest) J:35484 Kaufman SJ, et al., Expression of a developmentally regulated antigen on the surface of skeletal and cardiac muscle cells. J Cell Biol. 1985 Jun;100(6):1977-87
(Latest) J:208398 Korner Z, et al., Bortezomib Partially Improves Laminin alpha2 Chain-Deficient Muscular Dystrophy. Am J Pathol. 2014 May;184(5):1518-28
All references(106)
Other
accession IDs
MGD-MRK-19604

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory