Itga7
Gene Detail

Symbol Name ID

Itga7 integrin alpha 7 MGI:102700

Synonyms

[a]7, alpha7

Feature Type

protein coding gene

Genetic Map

Chromosome 10

77.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr10:128933813-128958277 bp, + strand From Ensembl annotation of GRCm38   24465 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37592  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga7

Human homologs

Human Homolog		ITGA7, integrin, alpha 7
NCBI Gene ID		3679
neXtProt AC		NX_Q13683
Human Chr (Location)		12q13; chr12:56078352-56106089 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ITGA7

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions of this gene display characteristics of muscular dystrophy.

 
Human Diseases Modeled Using Mouse Itga7 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	blood vessel morphogenesis, cell adhesion, ...
Component	cell surface, cytoplasm, ...
Function	cell adhesion molecule binding, integrin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (32 records)
Data Summary: Results (229)    Tissues (122)    Images (46)
Theiler Stages: 4, 5, 6, 8, 11, 15, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	19
RNA in situ	144
RT-PCR	66

cDNA source data(50)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(61) Genomic(3) cDNA(53) Primer pair(4) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000025348 (Evidence)
Entrez Gene	16404 (Evidence)
UniGene	179747
DFCI	TC1579951, TC1644099
DoTS	DT.40146185, DT.530750, DT.55277368
NIA Mouse Gene Index	U012206
Consensus CDS Project	CCDS24300.1
International Mouse Knockout Project Status	Itga7

Sequences

Length	Strain/Species
genomic	ENSMUSG00000025348	Ensembl Gene Model | MGI Sequence Detail	24465	C57BL/6J
transcript	ENSMUST00000099112	Ensembl | MGI Sequence Detail	4013	Not Applicable
polypeptide	ENSMUSP00000096712	Ensembl | MGI Sequence Detail	1136	Not Applicable

All sequences(32) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(98 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013649	Integrin alpha-2
InterPro	IPR013519	Integrin alpha beta-propellor
InterPro	IPR000413	Integrin alpha chain
InterPro	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology	PR:000009132	integrin alpha-7

References

(Earliest) J:35484 Kaufman SJ, et al., Expression of a developmentally regulated antigen on the surface of skeletal and cardiac muscle cells. J Cell Biol. 1985 Jun;100(6):1977-87
(Latest) J:193734 Stuelsatz P, et al., A contemporary atlas of the mouse diaphragm: myogenicity, vascularity, and the Pax3 connection. J Histochem Cytochem. 2012 Sep;60(9):638-57
All references(102)

Other accession IDs

MGD-MRK-19604