About   Help   FAQ
Itga7
Gene Detail
Symbol

Name
ID
Itga7
integrin alpha 7
MGI:102700
Synonyms
[a]7, alpha7
Feature Type
protein coding gene
Genetic Map
Chromosome 10
77.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:128933813-128958277 bp, + strand
From Ensembl annotation of GRCm38

  24465 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37592  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: ITGA7
Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga7

Human
homologs
ITGA7, integrin, alpha 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3679
neXtProt AC: NX_Q13683

Human Chr (Location): 12q13; chr12:55684568-55716037 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ITGA7

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene display characteristics of muscular dystrophy.
 
Human Diseases Modeled in Mice Using Itga7 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Itga7 interacts with 87 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process blood vessel morphogenesis, cell adhesion, ...
Component cell surface, cytoplasm, ...
Function cell adhesion molecule binding, integrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (234)    Tissues (126)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 25
RNA in situ 144
RT-PCR 65
cDNA source data(50)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase itga7    NEW 
Molecular
reagents
All nucleic(62) Genomic(3) cDNA(53) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000025348 (Evidence)
Entrez Gene 16404 (Evidence)
UniGene 179747
DFCI TC1579951, TC1644099
DoTS DT.40146185, DT.530750, DT.55277368
NIA Mouse Gene Index U012206
Consensus CDS Project CCDS24300.1
International Mouse Phenotyping Consortium Status Itga7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025348 Ensembl Gene Model | MGI Sequence Detail 24465 C57BL/6J ±  kb
transcript ENSMUST00000099112 Ensembl | MGI Sequence Detail 4013 Not Applicable 
polypeptide ENSMUSP00000096712 Ensembl | MGI Sequence Detail 1136 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(257 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology PR:000009132 integrin alpha-7
References
(Earliest) J:35484 Kaufman SJ, et al., Expression of a developmentally regulated antigen on the surface of skeletal and cardiac muscle cells. J Cell Biol. 1985 Jun;100(6):1977-87
(Latest) J:219598 Marshall JL, et al., Sarcospan integration into laminin-binding adhesion complexes that ameliorate muscular dystrophy requires utrophin and alpha7 integrin. Hum Mol Genet. 2015 Apr 1;24(7):2011-22
All references(110)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19604

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory