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Cst3
Gene Detail
Symbol

Name
ID
Cst3
cystatin C
MGI:102519
Synonyms
CysC
Feature Type
protein coding gene
Genetic Map
Chromosome 2
73.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr2:148871722-148875692 bp, - strand
From VEGA annotation of GRCm38

  3971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:78  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CST3
Gene Tree: Cst3

Human
homologs
CST3, cystatin C
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1471
neXtProt AC: NX_P01034

Human Synonyms: ARMD11

Human Chr (Location): 20p11.21; chr20:23627897-23638048 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CST3

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(13) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased metastatic potential and decreased susceptibility to ischemic brain injury.
 
Interactions
Cst3 interacts with 25 markers (Mir20b, Mir132, Mir135a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process defense response, extracellular fibril organization, ...
Component axon, basement membrane, ...
Function beta-amyloid binding, cysteine-type endopeptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (166)    Tissues (72)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 147
RT-PCR 12
cDNA source data(421)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(429) Genomic(1) cDNA(421) Primer pair(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015724 (Evidence)
Ensembl Gene Model ENSMUSG00000027447 (Evidence)
Entrez Gene 13010 (Evidence)
UniGene 4263
DFCI TC1573819
DoTS DT.537599, DT.94255981
NIA Mouse Gene Index U023470
Consensus CDS Project CCDS16852.1
International Mouse Phenotyping Consortium Status Cst3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015724 VEGA Gene Model | MGI Sequence Detail 3971 C57BL/6J ±  kb
transcript OTTMUST00000037353 VEGA | MGI Sequence Detail 860 Not Applicable 
polypeptide OTTMUSP00000016736 VEGA | MGI Sequence Detail 140 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027214 Cystatin
InterPro IPR000010 Proteinase inhibitor I25, cystatin
InterPro IPR018073 Proteinase inhibitor I25, cystatin, conserved site
Protein Ontology PR:000005965 cystatin-C
References
(Earliest) J:36252 Solem M, et al., Transforming growth factor beta regulates cystatin C in serum-free mouse embryo (SFME) cells. Biochem Biophys Res Commun. 1990 Oct 30;172(2):945-51
(Latest) J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
All references(69)
Other
accession IDs
MGD-MRK-19357

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory