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Cst3 Gene Detail
Summary
  • Symbol
    Cst3
  • Name
    cystatin C
  • Synonyms
    CysC
  • Feature Type
    protein coding gene
  • IDs
    MGI:102519
    NCBI Gene: 13010
  • Gene Overview
    MyGene.info: CST3
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:148871722-148875512 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 73.60 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    109 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102519
protein coding gene Chr2:148871722-148875692 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026620
protein coding gene Chr2:153243504-153247474 (-)
A/J MGP_AJ_G0026584
protein coding gene Chr2:146993176-146997146 (-)
AKR/J MGP_AKRJ_G0026558
protein coding gene Chr2:151243513-151247483 (-)
BALB/cJ MGP_BALBcJ_G0026596
protein coding gene Chr2:147424444-147428414 (-)
C3H/HeJ MGP_C3HHeJ_G0026339
protein coding gene Chr2:151735343-151739313 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027041
protein coding gene Chr2:157705628-157709598 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024419
protein coding gene Chr2:140987132-140991190 (-)
CAST/EiJ MGP_CASTEiJ_G0025800
protein coding gene Chr2:152138198-152142183 (-)
CBA/J MGP_CBAJ_G0026319
protein coding gene Chr2:163472742-163476712 (-)
DBA/2J MGP_DBA2J_G0026453
protein coding gene Chr2:146258401-146262371 (-)
FVB/NJ MGP_FVBNJ_G0026417
protein coding gene Chr2:144760493-144764478 (-)
LP/J MGP_LPJ_G0026557
protein coding gene Chr2:153363529-153367499 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026437
protein coding gene Chr2:167515187-167519171 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027096
protein coding gene Chr2:151245737-151249707 (-)
PWK/PhJ MGP_PWKPhJ_G0025536
protein coding gene Chr2:145943136-145947120 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025337
protein coding gene Chr2:150207711-150211857 (-)
WSB/EiJ MGP_WSBEiJ_G0025874
protein coding gene Chr2:152195134-152199085 (-)



Homology
more
  • Human Ortholog
    CST3, cystatin C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CST3, cystatin C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARMD11, HEL-S-2
  • Links
    NCBI Gene ID: 1471
    neXtProt AC: NX_P01034
    UniProt: P01034

  • Chr Location
    20p11.21; chr20:23627897-23638048 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 78
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CST3
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human CST3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased metastatic potential and decreased susceptibility to ischemic brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13010 NCBI Gene Model | MGI Sequence Detail 3791 C57BL/6J ±  kb
    transcript NM_009976 RefSeq | MGI Sequence Detail 813 C57BL/6  
    polypeptide P21460 UniProt | EBI | MGI Sequence Detail 140 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 431
      Genomic 1
      cDNA 422
      Primer pair 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19357
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 18
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:261809 Mayer C, et al., Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory