Cst3
Gene Detail

Symbol Name ID

Cst3 cystatin C MGI:102519

Synonyms

CysC

Feature Type

protein coding gene

Genetic Map

Chromosome 2

73.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr2:148871722-148875692 bp, - strand From VEGA annotation of GRCm38   3971 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:78  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Cst3

Human homologs

Human Homolog		CST3, cystatin C
NCBI Gene ID		1471
neXtProt AC		NX_P01034
Human Synonyms		ARMD11
Human Chr (Location)		20p11.21; chr20:23614294-23618574 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CST3

Alleles and phenotypes

All alleles(16) : Targeted(3) Gene trapped(13)
 

Mice homozygous for a null allele exhibit increased metastatic potential and decreased susceptibility to ischemic brain injury.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	defense response, extracellular fibril organization, ...
Component	axon part, basement membrane, ...
Function	beta-amyloid binding, cysteine-type endopeptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (166)    Tissues (72)    Images (40)
Theiler Stages: 5, 10, 12, 15, 16, 19, 20, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	147
RT-PCR	12

cDNA source data(411)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(418) Genomic(1) cDNA(411) Primer pair(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000015724 (Evidence)
Ensembl Gene Model	ENSMUSG00000027447 (Evidence)
Entrez Gene	13010 (Evidence)
UniGene	4263
DFCI	TC1573819
DoTS	DT.537599, DT.94255981
NIA Mouse Gene Index	U023470
Consensus CDS Project	CCDS16852.1
International Mouse Knockout Project Status	Cst3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015724	VEGA Gene Model | MGI Sequence Detail	3971	C57BL/6J
transcript	OTTMUST00000037353	VEGA | MGI Sequence Detail	860	Not Applicable
polypeptide	OTTMUSP00000016736	VEGA | MGI Sequence Detail	140	Not Applicable

All sequences(42) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(2) : SNPs(54 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000010	Proteinase inhibitor I25, cystatin
InterPro	IPR018073	Proteinase inhibitor I25, cystatin, conserved site
Protein Ontology	PR:000005965	cystatin-C

References

(Earliest) J:36252 Solem M, et al., Transforming growth factor beta regulates cystatin C in serum-free mouse embryo (SFME) cells. Biochem Biophys Res Commun. 1990 Oct 30;172(2):945-51
(Latest) J:176715 Ghidoni R, et al., Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer's disease. Neurobiol Aging. 2011 Aug;32(8):1435-42
All references(66)

Other accession IDs

MGD-MRK-19357