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Cst3
Gene Detail
 Symbol
Name
ID
Cst3
cystatin C
MGI:102519
Synonyms CysC
Feature Type protein coding gene
Genetic Map
Chromosome 2
73.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr2:148871722-148875692 bp, - strand
From VEGA annotation of GRCm38

  3971 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:78  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Cst3

Human
homologs
Human Homolog CST3, cystatin C
NCBI Gene ID 1471
neXtProt AC  NX_P01034
Human Synonyms  ARMD11
Human Chr (Location)  20p11.21; chr20:23627897-23638048 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CST3
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(13) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased metastatic potential and decreased susceptibility to ischemic brain injury.
 
Interactions
Cst3 interacts with 25 markers (Mir20b, Mir132, Mir135a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process defense response, extracellular fibril organization, ...
Component axon, basement membrane, ...
Function beta-amyloid binding, cysteine-type endopeptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (166)    Tissues (72)    Images (40)
Theiler Stages: 4, 5, 10, 12, 15, 16, 19, 20, 22, 23, 24, 27, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 147
RT-PCR 12
cDNA source data(421)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(428) Genomic(1) cDNA(421) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015724 (Evidence)
Ensembl Gene ModelENSMUSG00000027447 (Evidence)
Entrez Gene13010 (Evidence)
UniGene4263
DFCITC1573819
DoTSDT.537599, DT.94255981
NIA Mouse Gene IndexU023470
Consensus CDS ProjectCCDS16852.1
International Mouse Knockout Project StatusCst3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015724 VEGA Gene Model | MGI Sequence Detail 3971 C57BL/6J ±  kb
transcript OTTMUST00000037353 VEGA | MGI Sequence Detail 860 Not Applicable 
polypeptide OTTMUSP00000016736 VEGA | MGI Sequence Detail 140 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(112 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027214 Cystatin
InterPro IPR000010 Proteinase inhibitor I25, cystatin
InterPro IPR018073 Proteinase inhibitor I25, cystatin, conserved site
Protein Ontology PR:000005965 cystatin-C
References (Earliest) J:36252 Solem M, et al., Transforming growth factor beta regulates cystatin C in serum-free mouse embryo (SFME) cells. Biochem Biophys Res Commun. 1990 Oct 30;172(2):945-51
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(68)
Other
accession IDs
MGD-MRK-19357

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory