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Nfatc2 Gene Detail
Summary
  • Symbol
    Nfatc2
  • Name
    nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
  • Synonyms
    NFAT1, NFAT1-D, NFATp
  • Feature Type
    protein coding gene
  • IDs
    MGI:102463
    NCBI Gene: 18019
  • Gene Overview
    MyGene.info: NFATC2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:168476410-168601657 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      125248 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 88.91 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    NFATC2, nuclear factor of activated T cells 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NFATC2, nuclear factor of activated T cells 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NFAT1, NFATP
  • Links
    NCBI Gene ID: 4773
    neXtProt AC: NX_Q13469
    UniProt: Q13469

  • Chr Location
    20q13.2; chr20:51386957-51562857 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7861
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NFATC2
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 6 alleles in 8 genetic backgrounds
    28 phenotypes from multigenic genotypes
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this locus cause altered immune system function such as decreased cytokine production by mast cells, increased Th2 responses after infection with a parasite but decreased Th1 responses after myobacterial infection, retarded thymic involutionand massive germinal center formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016052 VEGA Gene Model | MGI Sequence Detail 125248 C57BL/6J ±  kb
    transcript OTTMUST00000038308 VEGA | MGI Sequence Detail 6637 Not Applicable  
    polypeptide OTTMUSP00000017171 VEGA | MGI Sequence Detail 927 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      833 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 4
      cDNA 38
      Primer pair 4

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-12824, MGD-MRK-19300, MGI:2139019
    References
    more
    • Summaries
      All 178
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 32
      Phenotypes 70
    • Earliest
      J:15443 McCaffrey PG, et al., Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science. 1993 Oct 29;262(5134):750-4
    • Latest
      J:259234 Vaeth M, et al., Store-Operated Ca(2+) Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming. Immunity. 2017 Oct 17;47(4):664-679.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory