About   Help   FAQ
Nfatc2 Gene Detail
Summary
  • Symbol
    Nfatc2
  • Name
    nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
  • Synonyms
    NFAT1, NFAT1-D, NFATp
  • Feature Type
    protein coding gene
  • IDs
    MGI:102463
    NCBI Gene: 18019
  • Gene Overview
    MyGene.info: NFATC2
Location & Maps
more
  • Sequence Map
    Chr2:168476410-168601657 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      125248 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 88.91 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    NFATC2, nuclear factor of activated T-cells 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NFATC2, nuclear factor of activated T-cells 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NFAT1, NFATP
  • Links
    NCBI Gene ID: 4773
    neXtProt AC: NX_Q13469

  • Chr Location
    20q13.2; chr20:51386957-51562858 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7861
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NFATC2
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 6 alleles in 8 genetic backgrounds
    28 phenotypes from multigenic genotypes
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    1
  • Gene trapped
    7
  • Targeted
    7
  • Incidental Mutations
Mutations in this locus cause altered immune system function such as decreased cytokine production by mast cells, increased Th2 responses after infection with a parasite but decreased Th1 responses after myobacterial infection, retarded thymic involutionand massive germinal center formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016052 VEGA Gene Model | MGI Sequence Detail 125248 C57BL/6J ±  kb
transcript OTTMUST00000038308 VEGA | MGI Sequence Detail 6637 Not Applicable  
polypeptide OTTMUSP00000017171 VEGA | MGI Sequence Detail 927 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    833 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    17 Sequences
  • Protein Ontology
    PR:000011164 nuclear factor of activated T-cells, cytoplasmic 2
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR013783 Immunoglobulin-like fold
    IPR002909 IPT domain
    IPR008366 Nuclear factor of activated T cells (NFAT)
    IPR008967 p53-like transcription factor, DNA-binding
    IPR032397 Rel homology dimerisation domain
    IPR011539 Rel homology domain (RHD), DNA-binding domain
Molecular
Reagents
less
  • All nucleic 45
    Genomic 4
    cDNA 38
    Primer pair 3

    Microarray probesets 11
Other
Accession IDs
less
MGD-MRK-12824, MGD-MRK-19300, MGI:2139019
References
more
  • Summaries
    All 153
    Developmental Gene Expression 15
    Diseases 1
    Gene Ontology 29
    Phenotypes 68
  • Earliest
    J:15443 McCaffrey PG, et al., Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science. 1993 Oct 29;262(5134):750-4
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory