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Nfatc2
Gene Detail
 Symbol
Name
ID
Nfatc2
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
MGI:102463
Synonyms NFAT1, NFAT1-D, NFATp
Feature Type protein coding gene
Genetic Map
Chromosome 2
88.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:168476410-168601657 bp, - strand
From VEGA annotation of GRCm38

  125248 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7861  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nfatc2

Human
homologs
Human Homolog NFATC2, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NCBI Gene ID 4773
neXtProt AC  NX_Q13469
Human Synonyms  NFAT1, NFATP
Human Chr (Location)  20q13.2; chr20:51386957-51562831 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(1) Gene trapped(7) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this locus cause altered immune system function such as decreased cytokine production by mast cells, increased Th2 responses after infection with a parasite but decreased Th1 responses after myobacterial infection, retarded thymic involution and massive germinal center formation.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Nfatc2 interacts with 370 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process B cell receptor signaling pathway, cell migration, ...
Component actin cytoskeleton, cytoplasm, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (158)    Tissues (126)    Images (19)
Theiler Stages: 17, 19, 21, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 156
RT-PCR 2
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) Genomic(4) cDNA(38) Primer pair(3)
Microarray probesets(11)
Other database
links
VEGA Gene ModelOTTMUSG00000016052 (Evidence)
Ensembl Gene ModelENSMUSG00000027544 (Evidence)
Entrez Gene18019 (Evidence)
UniGene116802
DFCITC1585857, TC1587827, TC1625864, TC1630790, TC1637462
DoTSDT.101367250, DT.101367251, DT.55149551, DT.87038091, DT.91559754, DT.94248460, DT.97335564, DT.97359441, DT.97369735
NIA Mouse Gene IndexU023695
Consensus CDS ProjectCCDS17112.1, CCDS17113.1, CCDS17114.1, CCDS50803.1, CCDS71201.1
International Mouse Knockout Project StatusNfatc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016052 VEGA Gene Model | MGI Sequence Detail 125248 C57BL/6J ±  kb
transcript OTTMUST00000038308 VEGA | MGI Sequence Detail 6637 Not Applicable 
polypeptide OTTMUSP00000017171 VEGA | MGI Sequence Detail 927 Not Applicable 

For the selected sequences
All sequences(135) RefSeq(34) UniProt(17)
Polymorphisms RFLP(1) : SNPs within 2kb(831 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR008366 Nuclear factor of activated T cells (NFAT)
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR011539 Rel homology domain
Protein Ontology PR:000011164 nuclear factor of activated T-cells, cytoplasmic 2
References (Earliest) J:15443 McCaffrey PG, et al., Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science. 1993 Oct 29;262(5134):750-4
(Latest) J:208305 Dirkx E, et al., Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure. Nat Cell Biol. 2013 Nov;15(11):1282-93
All references(145)
Other
accession IDs
MGD-MRK-12824, MGD-MRK-19300, MGI:2139019

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory