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Pou3f2 Gene Detail
Summary
  • Symbol
    Pou3f2
  • Name
    POU domain, class 3, transcription factor 2
  • Synonyms
    9430075J19Rik, A230098E07Rik, Brn2, Brn-2, Otf7
  • Feature Type
    protein coding gene
  • IDs
    MGI:101895
    NCBI Gene: 18992
  • Gene Overview
    MyGene.info: POU3F2
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:22482780-22488366 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 9.73 cM
  • Mapping Data
    5 experiments
  • Sequence Tag
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101895
protein coding gene Chr4:22482095-22488366 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028097
protein coding gene Chr4:19551608-19557157 (-)
A/J MGP_AJ_G0028055
protein coding gene Chr4:18967620-18973187 (-)
AKR/J MGP_AKRJ_G0028020
protein coding gene Chr4:19393750-19399418 (-)
BALB/cJ MGP_BALBcJ_G0028066
protein coding gene Chr4:19015658-19021271 (-)
C3H/HeJ MGP_C3HHeJ_G0027796
protein coding gene Chr4:19569243-19575688 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028509
protein coding gene Chr4:20313379-20318951 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025851
protein coding gene Chr4:17583937-17589692 (-)
CAST/EiJ MGP_CASTEiJ_G0027251
protein coding gene Chr4:19369046-19374593 (-)
CBA/J MGP_CBAJ_G0027769
protein coding gene Chr4:20918412-20923997 (-)
DBA/2J MGP_DBA2J_G0027912
protein coding gene Chr4:18853158-18858754 (-)
FVB/NJ MGP_FVBNJ_G0027878
protein coding gene Chr4:18528122-18533796 (-)
LP/J MGP_LPJ_G0028021
protein coding gene Chr4:19638969-19644571 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027911
protein coding gene Chr4:22138143-22145579 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028568
protein coding gene Chr4:19348875-19354477 (-)
PWK/PhJ MGP_PWKPhJ_G0026971
protein coding gene Chr4:18677210-18682851 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026800
protein coding gene Chr4:19181214-19187900 (-)
WSB/EiJ MGP_WSBEiJ_G0027328
protein coding gene Chr4:19333358-19340626 (-)



Homology
more
  • Human Ortholog
    POU3F2, POU class 3 homeobox 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    POU3F2, POU class 3 homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    brn-2, BRN2, N-Oct3, oct-7, OCT7, OTF7, OTF-7, POUF3
  • Links
    NCBI Gene ID: 5454
    neXtProt AC: NX_P20265
    UniProt: P20265

  • Chr Location
    6q16.1; chr6:98834704-98838790 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality by 10 days of age. Mutant animals are growth retarded, have hyperkeratotic, flaky skin, and exhibit loss of the posterior pituitary and disruption of late endocrine hypothalamic development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000095139 Ensembl Gene Model | MGI Sequence Detail 5587 C57BL/6J ±  kb
    transcript ENSMUST00000178174 Ensembl | MGI Sequence Detail 5587 Not Applicable  
    polypeptide ENSMUSP00000136147 Ensembl | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 2
      cDNA 19
      Primer pair 5
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13082, MGD-MRK-1624, MGD-MRK-1628, MGD-MRK-18722, MGI:1924614, MGI:2443081
    References
    more
    • Summaries
      All 159
      Developmental Gene Expression 106
      Gene Ontology 16
      Phenotypes 10
    • Earliest
      J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
    • Latest
      J:259631 Hashizume K, et al., POU3F2 participates in cognitive function and adult hippocampal neurogenesis via mammalian-characteristic amino acid repeats. Genes Brain Behav. 2018 Feb;17(2):118-125

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory