About   Help   FAQ
Pou3f2
Gene Detail
Symbol

Name
ID
Pou3f2
POU domain, class 3, transcription factor 2
MGI:101895
STS
Synonyms
9430075J19Rik, A230098E07Rik, Brn2, Brn-2, Otf7
Feature Type
protein coding gene
Genetic Map
Chromosome 4
9.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:22482780-22488366 bp, - strand
From VEGA annotation of GRCm38

  5587 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4095  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: POU3F2
Protein SuperFamily: POU domain class 3 transcription factor, brain type
Gene Tree: Pou3f2

Human
homologs
POU3F2, POU class 3 homeobox 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5454
neXtProt AC: NX_P20265

Human Synonyms: brn-2, BRN2, N-Oct3, oct-7, OCT7, OTF7, OTF-7, POUF3

Human Chr (Location): 6q16; chr6:98834704-98838790 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality by 10 days of age. Mutant animals are growth retarded, have hyperkeratotic, flaky skin, and exhibit loss of the posterior pituitary and disruption of late endocrine hypothalamic development.
 
Interactions
Pou3f2 interacts with 425 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process astrocyte development, cellular response to organic substance, ...
Component nucleus, transcription factor complex
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (82 records)
Data Summary: Results (208)    Tissues (172)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 28
RNA in situ 179
RT-PCR 1
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN pou3f2a, pou3f2b    NEW 
Molecular
reagents
All nucleic(24) Genomic(2) cDNA(16) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000004749 (Evidence)
Ensembl Gene Model ENSMUSG00000095139 (Evidence)
Entrez Gene 18992 (Evidence)
DFCI TC1646000, TC1598925, TC1598671
DoTS DT.87071029, DT.101300997, DT.101344831
NIA Mouse Gene Index U024883
Consensus CDS Project CCDS18005.1
International Mouse Phenotyping Consortium Status Pou3f2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004749 VEGA Gene Model | MGI Sequence Detail 5587 C57BL/6J ±  kb
transcript OTTMUST00000010681 VEGA | MGI Sequence Detail 5587 Not Applicable 
polypeptide OTTMUSP00000005047 VEGA | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(0 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
Protein Ontology PR:000013039 POU domain, class 3, transcription factor 2
References
(Earliest) J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
(Latest) J:217395 Ritchie K, et al., ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain. Biol Open. 2014;3(12):1158-63
All references(124)
Other
accession IDs
MGD-MRK-13082, MGD-MRK-1624, MGD-MRK-1628, MGD-MRK-18722, MGI:1924614, MGI:2443081

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory