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Pou3f2 Gene Detail
Summary
  • Symbol
    Pou3f2
  • Name
    POU domain, class 3, transcription factor 2
  • Synonyms
    9430075J19Rik, A230098E07Rik, Brn2, Brn-2, Otf7
  • Feature Type
    protein coding gene
  • IDs
    MGI:101895
    NCBI Gene: 18992
  • Gene Overview
    MyGene.info: POU3F2
Location & Maps
more
  • Sequence Map
    Chr4:22482780-22488366 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5587 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 9.73 cM
  • Mapping Data
    5 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    POU3F2, POU class 3 homeobox 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    POU3F2, POU class 3 homeobox 2
    Orthology source: HomoloGene
  • Synonyms
    brn-2, BRN2, N-Oct3, oct-7, OCT7, OTF7, OTF-7, POUF3
  • Links
    NCBI Gene ID: 5454
    neXtProt AC: NX_P20265

  • Chr Location
    6q16; chr6:98834704-98838790 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality by 10 days of age. Mutant animals are growth retarded, have hyperkeratotic, flaky skin, and exhibit loss of the posterior pituitary and disruption of late endocrine hypothalamic development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004749 VEGA Gene Model | MGI Sequence Detail 5587 C57BL/6J ±  kb
transcript OTTMUST00000010681 VEGA | MGI Sequence Detail 5587 Not Applicable  
polypeptide OTTMUSP00000005047 VEGA | MGI Sequence Detail 445 Not Applicable  
For the selected sequence
Polymorphisms
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  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 26
    Genomic 2
    cDNA 17
    Primer pair 5
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13082, MGD-MRK-1624, MGD-MRK-1628, MGD-MRK-18722, MGI:1924614, MGI:2443081
References
more
  • Summaries
    All 130
    Developmental Gene Expression 91
    Gene Ontology 13
    Phenotypes 7
  • Earliest
    J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
  • Latest
    J:231532 Lange C, et al., Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis. EMBO J. 2016 May 2;35(9):924-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory