About   Help   FAQ
Pou3f2
Gene Detail
 Symbol
Name
ID
Pou3f2
POU domain, class 3, transcription factor 2
MGI:101895
STS D4Mit171
Synonyms 9430075J19Rik, A230098E07Rik, Brn2, Brn-2, Otf7
Feature Type protein coding gene
Genetic Map
Chromosome 4
9.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:22485521-22488366 bp, - strand
From VEGA annotation of GRCm38

  2846 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4095  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: POU domain class 3 transcription factor, brain type
Gene Tree: Pou3f2

Human
homologs
Human Homolog POU3F2, POU class 3 homeobox 2
NCBI Gene ID 5454
neXtProt AC  NX_P20265
Human Synonyms  brn-2, BRN2, N-Oct3, oct-7, OCT7, OTF7, OTF-7, POUF3
Human Chr (Location)  6q16; chr6:98834704-98838790 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality by 10 days of age. Mutant animals are growth retarded, have hyperkeratotic, flaky skin, and exhibit loss of the posterior pituitary and disruption of late endocrine hypothalamic development.
 
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process astrocyte development, cellular response to organic substance, ...
Component nucleus, transcription factor complex
Function DNA binding, HMG box domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (73 records)
Data Summary: Results (172)    Tissues (155)    Images (33)
Theiler Stages: 13, 15, 17, 18, 19, 20, 21, 22, 23, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 169
RT-PCR 1
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) Genomic(2) cDNA(16) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000004749 (Evidence)
Ensembl Gene ModelENSMUSG00000095139 (Evidence)
Entrez Gene18992 (Evidence)
DFCITC1598671, TC1598925, TC1646000
DoTSDT.101300997, DT.101344831, DT.87071029
NIA Mouse Gene IndexU024883
Consensus CDS ProjectCCDS18005.1
International Mouse Knockout Project StatusPou3f2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004749 VEGA Gene Model | MGI Sequence Detail 2846 C57BL/6J ±  kb
transcript OTTMUST00000010681 VEGA | MGI Sequence Detail 2846 Not Applicable 
polypeptide OTTMUSP00000005047 VEGA | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(0 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific
InterPro IPR016362 Transcription factor, homeobox/POU
Protein Ontology PR:000013039 POU domain, class 3, transcription factor 2
References (Earliest) J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
(Latest) J:203750 Tong KK, et al., Common partner Smad-independent canonical bone morphogenetic protein signaling in the specification process of the anterior rhombic lip during cerebellum development. Mol Cell Biol. 2013 May;33(10):1925-37
All references(118)
Other
accession IDs
MGD-MRK-13082, MGD-MRK-1624, MGD-MRK-1628, MGD-MRK-18722, MGI:1924614, MGI:2443081

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory