Ccl8 Gene Detail

Summary

• Symbol
  Ccl8
• Name
  C-C motif chemokine ligand 8
• Synonyms
  1810063B20Rik, HC14, MCP-2, Scya8

• Feature Type
  protein coding gene
• IDs
  MGI:101878
  NCBI Gene: 20307
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr11:82006011-82007625 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 49.91 cM
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  27 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101878	protein coding gene	Chr11:82006011-82007625 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018825	protein coding gene	Chr11:83363487-83365101 (+)
A/J	MGP_AJ_G0018792	protein coding gene	Chr11:80158248-80159862 (+)
AKR/J	MGP_AKRJ_G0018762	protein coding gene	Chr11:82556806-82558420 (+)
BALB/cJ	MGP_BALBcJ_G0018765	protein coding gene	Chr11:80551472-80553086 (+)
C3H/HeJ	MGP_C3HHeJ_G0018579	protein coding gene	Chr11:82605636-82607250 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019217	protein coding gene	Chr11:85865131-85866745 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016851	protein coding gene	Chr11:77131489-77133104 (+)
CAST/EiJ	MGP_CASTEiJ_G0018134	protein coding gene	Chr11:83164502-83166121 (+)
CBA/J	MGP_CBAJ_G0018550	protein coding gene	Chr11:89630485-89632099 (+)
DBA/2J	MGP_DBA2J_G0018658	protein coding gene	Chr11:79720517-79722131 (+)
FVB/NJ	MGP_FVBNJ_G0018647	protein coding gene	Chr11:79266599-79268213 (+)
LP/J	MGP_LPJ_G0018728	protein coding gene	Chr11:83893097-83894711 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018674	protein coding gene	Chr11:89811040-89812654 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019257	protein coding gene	Chr11:82822608-82824222 (+)
PWK/PhJ	MGP_PWKPhJ_G0017904	protein coding gene	Chr11:80547316-80548937 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017695	protein coding gene	Chr11:82440477-82442100 (+)
WSB/EiJ	MGP_WSBEiJ_G0018186	protein coding gene	Chr11:82700509-82702123 (+)

Homology

• Human Ortholog
  CCL8, C-C motif chemokine ligand 8

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CCL8, C-C motif chemokine ligand 8
  
• Synonyms
  HC14, MCP2, MCP-2, SCYA10, SCYA8
• Links
  HGNC:10635

  NCBI Gene ID: 6355

  neXtProt AC: NX_P80075

  UniProt: P80075

  
  
• Chr Location
  17q12; chr17:34319435-34321402 (+)  GRCh38

---

• MGI Vertebrate Homology
  Ccl8 stringent orthology
  1 human;1 mouse;2 zebrafish
  
• HCOP
  vertebrate homology predictions: CCL8
• Gene Tree
  Ccl8
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  20 phenotype references
  

• All Mutations and Alleles
  10
• Chemically induced (other)
  1
• Endonuclease-mediated
  4
• Targeted
  5
• Genomic Mutations
  2 involving Ccl8
• Incidental Mutations
  APF , CvDC
• Find Mice (IMSR)
  16 strains or lines available

Some alleles of Ccl12 also affect expression of this gene.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  22
• GO References
  5

Expression

• Assay Results
  740
• Tissues
  20
• cDNA Data
  14
• Literature Summary
  5

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  34
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS36248.1

• Ensembl
  ENSMUSG00000009185 (Evidence)
• NCBI Gene
  20307

Representative Sequences			Length	Strain/Species
genomic	20307	NCBI Gene Model | MGI Sequence Detail	1615	C57BL/6J
transcript	NM_021443	RefSeq | MGI Sequence Detail	517	ZRU/MplStud
polypeptide	Q9Z121	UniProt | EBI | MGI Sequence Detail	97	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• InterPro Domains
  IPR000827 CC chemokine, conserved site
  IPR039809 Chemokine beta/gamma/delta
  IPR001811 Chemokine interleukin-8-like domain
  IPR036048 Chemokine interleukin-8-like superfamily

Molecular
Reagents

• All nucleic 15

  Genomic 1

  cDNA 14

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-18704, MGI:1913124, MGI:1917105

References

• Summaries
  All 63

  Developmental Gene Expression 5

  Gene Ontology 5

  Phenotypes 20
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:345170 Kim HS, et al., Mesenchymal stem cells enhance CCL8 expression by podocytes in lupus-prone MRL.Fas(lpr) mice. Sci Rep. 2023 Aug 11;13(1):13074

TSS for Ccl8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103570	Chr11:82006006-82006012 (+)	-2 bp