About   Help   FAQ
Tcf12 Gene Detail
Summary
  • Symbol
    Tcf12
  • Name
    transcription factor 12
  • Synonyms
    ALF1, bHLHb20, HEB, HEBAlt, HTF-4, HTF4, ME1, REB
  • Feature Type
    protein coding gene
  • IDs
    MGI:101877
    NCBI Gene: 21406
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
  • Regulated by
    Rr406442, Rr380 (2 regulatory regions)
Location &
Maps
more
  • Sequence Map
    Chr9:71751534-72019611 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.85 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5373 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101877
 protein coding gene Chr9:71749970-72019611 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035012
 protein coding gene Chr9:71980518-72253045 (-)
A/J MGP_AJ_G0034993
 protein coding gene Chr9:69463764-69728013 (-)
AKR/J MGP_AKRJ_G0034922
 protein coding gene Chr9:71130169-71398641 (-)
BALB/cJ MGP_BALBcJ_G0034985
 protein coding gene Chr9:69178675-69439803 (-)
C3H/HeJ MGP_C3HHeJ_G0034694
 protein coding gene Chr9:71635356-71906431 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035504
 protein coding gene Chr9:73880144-74155285 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032415
 protein coding gene Chr9:68982362-69241246 (-)
CAST/EiJ MGP_CASTEiJ_G0034016
 protein coding gene Chr9:71921623-72200086 (-)
CBA/J MGP_CBAJ_G0034667
 protein coding gene Chr9:76444918-76727403 (-)
DBA/2J MGP_DBA2J_G0034826
 protein coding gene Chr9:69192002-69455312 (-)
FVB/NJ MGP_FVBNJ_G0034768
 protein coding gene Chr9:68511076-68773741 (-)
LP/J MGP_LPJ_G0034907
 protein coding gene Chr9:72190968-72458388 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034809
 protein coding gene Chr9:77493002-77782306 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035526
 protein coding gene Chr9:71265622-71536917 (-)
PWK/PhJ MGP_PWKPhJ_G0033720
 protein coding gene Chr9:69445467-69710301 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033553
 protein coding gene Chr9:71580786-71851311 (-)
WSB/EiJ MGP_WSBEiJ_G0034128
 protein coding gene Chr9:71194974-71463828 (-)



Homology
more
  • Human Ortholog
    TCF12, transcription factor 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCF12, transcription factor 12
  • Synonyms
    bHLHb20, CRS3, HEB, HH26, HsT17266, HTF4, p64, TCF-12
  • Links
    NCBI Gene ID: 6938
    UniProt: Q99081

  • Chr Location
    15q21.3; chr15:56918090-57299281 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TCF12 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 6 alleles in 8 genetic backgrounds
    28 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit postnatal lethality within two weeks of birth and a 50% reduction in the number of pro-B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1065
  • Tissues
    270
  • cDNA Data
    250
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21406 NCBI Gene Model | MGI Sequence Detail 268078 C57BL/6J ±  kb
    transcript NM_011544 RefSeq | MGI Sequence Detail 4707 ZRU/MplStud  
    polypeptide Q61286 UniProt | EBI | MGI Sequence Detail 706 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      19 Sequences
    • Protein Ontology
      PR:000016176 transcription factor 12
      (term hierarchy)
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR051098 Neuronal Differentiation E-box Binding Transcription Factors
    • GlyGen
      Q61286 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 261
      Genomic 1
      cDNA 251
      Primer pair 6
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18703
    References
    more
    • Summaries
      All 153
      Developmental Gene Expression 43
      Gene Ontology 17
      Phenotypes 58
    • Earliest
      J:18120 Sun XH, et al., Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol. 1991 Nov;11(11):5603-11
    • Latest
      J:363327 Sepp M, et al., Cellular development and evolution of the mammalian cerebellum. Nature. 2024 Jan;625(7996):788-796
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory