Tcf12 MGI Mouse Gene Detail - MGI:101877

Tcf12 Gene Detail

Symbol

Tcf12
Name

transcription factor 12
Synonyms

ALF1, bHLHb20, HEB, HEBAlt, HTF4, HTF-4, ME1, REB

Feature Type

protein coding gene
IDs

MGI:101877
NCBI Gene: 21406
Gene Overview

MyGene.info: TCF12
Alliance

gene page

Sequence Map

Chr9:71842688-72111871 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

269184 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 39.85 cM
Mapping Data

8 experiments

Human Ortholog

TCF12, transcription factor 12

Vertebrate Orthologs

10

Human Ortholog

TCF12, transcription factor 12
Orthology source: HomoloGene, HGNC
Synonyms

bHLHb20, CRS3, HEB, HsT17266, HTF4, TCF-12
Links

HGNC:11623

NCBI Gene ID: 6938

neXtProt AC: NX_Q99081

UniProt: Q99081
Chr Location

15q21.3; chr15:56918090-57291261 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 40774
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: TCF12
Protein SuperFamily

transcription factor 3
Gene Tree

Tcf12

Diseases

1 with human TCF12 associations

				Human Disease	Mouse Models
				craniosynostosis IDs craniosynostosis DOID:2340 ICD10CM:Q75.0 MESH:D003398 NCI:C84655 OMIM:123100 OMIM:182212 OMIM:600593 OMIM:600775 OMIM:604757 OMIM:615314 OMIM:615529 ORDO:1531 UMLS_CUI:C0010278

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

20 phenotypes from 3 alleles in 5 genetic backgrounds
19 phenotypes from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Chemically induced (other)

1
Gene trapped

35
Targeted

3
Genomic Mutations

1 involving Tcf12
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

57 strains or lines available

Mice homozygous for a targeted null mutation exhibit postnatal lethality within two weeks of birth and a 50% reduction in the number of pro-B cells.

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All GO Annotations

43
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

299
Tissues

230
cDNA Data

247
Literature Summary

25

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TCF12

ZFIN tcf12

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Tcf12 interacts with 432 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

142
RefSeq

28
UniProt

19
CCDS

CCDS23329.1, CCDS72271.1, CCDS72272.1
UniGene

171615

			Length	Strain/Species	Flank
genomic	OTTMUSG00000044751	VEGA Gene Model \| MGI Sequence Detail	269184	C57BL/6J	± kb
transcript	OTTMUST00000117656	VEGA \| MGI Sequence Detail	6299	Not Applicable
polypeptide	OTTMUSP00000065761	VEGA \| MGI Sequence Detail	706	Not Applicable

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SNPs within 2kb

1341 from dbSNP Build 142

RFLP

1

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UniProt

19 Sequences
Protein Ontology

PR:000016176 transcription factor 12

(term hierarchy)
InterPro Domains

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

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All nucleic 255

Genomic 1

cDNA 248

Primer pair 5

Other 1

Microarray probesets 4

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MGD-MRK-18703

Summaries

All 96

Developmental Gene Expression 25

Gene Ontology 13

Phenotypes 32
Earliest

J:18120 Sun XH, et al., Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol. 1991 Nov;11(11):5603-11
Latest

J:221879 Yoon SJ, et al., HEB associates with PRC2 and SMAD2/3 to regulate developmental fates. Nat Commun. 2015;6:6546

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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