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Tcf12
Gene Detail
Symbol

Name
ID
Tcf12
transcription factor 12
MGI:101877
Synonyms
ALF1, bHLHb20, HEB, HEBAlt, HTF4, HTF-4, ME1, REB
Feature Type
protein coding gene
Genetic Map
Chromosome 9
39.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr9:71842688-72111871 bp, - strand
From VEGA annotation of GRCm38

  269184 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor 3
Gene Tree: Tcf12

Human
homologs
Human Homolog TCF12, transcription factor 12
NCBI Gene ID 6938
neXtProt AC  NX_Q99081
Human Synonyms  bHLHb20, CRS3, HEB, HsT17266, HTF4
Human Chr (Location)  15q21; chr15:56918635-57288520 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TCF12
Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(38) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation exhibit postnatal lethality within two weeks of birth and a 50% reduction in the number of pro-B cells.
 
Interactions
Tcf12 interacts with 433 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cell differentiation, multicellular organismal development, ...
Component cytoplasm, nuclear chromatin, ...
Function bHLH transcription factor binding, cAMP response element binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (299)    Tissues (230)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 272
Northern blot 9
RT-PCR 18
cDNA source data(247)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(255) Genomic(1) cDNA(248) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000044751 (Evidence)
Ensembl Gene ModelENSMUSG00000032228 (Evidence)
Entrez Gene21406 (Evidence)
UniGene171615
DFCITC1583480, TC1585952, TC1627947, TC1671446, TC1578733
DoTSDT.101394004, DT.99857779, DT.55252504, DT.94224421, DT.55261901, DT.91576903, DT.101249727, DT.55257388
NIA Mouse Gene IndexU031072
Consensus CDS ProjectCCDS23329.1, CCDS72271.1, CCDS72272.1
International Mouse Knockout Project StatusTcf12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044751 VEGA Gene Model | MGI Sequence Detail 269184 C57BL/6J ±  kb
transcript OTTMUST00000117656 VEGA | MGI Sequence Detail 6299 Not Applicable 
polypeptide OTTMUSP00000065761 VEGA | MGI Sequence Detail 706 Not Applicable 

For the selected sequences
All sequences(174) RefSeq(28) UniProt(37)
Polymorphisms
RFLP(1) : SNPs within 2kb(1350 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016176 transcription factor 12
References
(Earliest) J:18120 Sun XH, et al., Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol. 1991 Nov;11(11):5603-11
(Latest) J:209824 D'Cruz LM, et al., E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation. J Immunol. 2014 Mar 1;192(5):2227-36
All references(97)
Other
accession IDs
MGD-MRK-18703

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory