Tcf12
Gene Detail

Symbol

Name
ID

Tcf12
transcription factor 12
MGI:101877

Synonyms

ALF1, bHLHb20, HEB, HEBAlt, HTF4, HTF-4, ME1, REB

Feature Type

protein coding gene

Genetic Map

Chromosome 9
39.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr9:71842688-72111871 bp, - strand From VEGA annotation of GRCm38   269184 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:40774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor 3
Gene Tree: Tcf12

Human
homologs

Human Homolog		TCF12, transcription factor 12
NCBI Gene ID		6938
neXtProt AC		NX_Q99081
Human Synonyms		bHLHb20, CRS3, HEB, HsT17266, HTF4
Human Chr (Location)		15q21; chr15:56918635-57288520 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human TCF12

Mutations,
alleles, and
phenotypes

All mutations/alleles(41) : Gene trapped(38) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a targeted null mutation exhibit postnatal lethality within two weeks of birth and a 50% reduction in the number of pro-B cells.

 

Interactions

Tcf12 interacts with 433 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (35 annotations)

Process	cell differentiation, multicellular organismal development, ...
Component	cytoplasm, nuclear chromatin, ...
Function	bHLH transcription factor binding, cAMP response element binding, ...

External Resources: FuncBase

Expression

Literature Summary: (25 records)

Data Summary: Results (299)    Tissues (230)    Images (42)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	272
Northern blot	9
RT-PCR	18

cDNA source data(247)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(255) Genomic(1) cDNA(248) Primer pair(5) Other(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000044751 (Evidence)
Ensembl Gene Model	ENSMUSG00000032228 (Evidence)
Entrez Gene	21406 (Evidence)
UniGene	171615
DFCI	TC1585952, TC1627947, TC1671446, TC1578733, TC1583480
DoTS	DT.55261901, DT.91576903, DT.94224421, DT.55257388, DT.101394004, DT.101249727, DT.55252504, DT.99857779
NIA Mouse Gene Index	U031072
Consensus CDS Project	CCDS23329.1, CCDS72271.1, CCDS72272.1
International Mouse Knockout Project Status	Tcf12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000044751	VEGA Gene Model | MGI Sequence Detail	269184	C57BL/6J
transcript	OTTMUST00000117656	VEGA | MGI Sequence Detail	6299	Not Applicable
polypeptide	OTTMUSP00000065761	VEGA | MGI Sequence Detail	706	Not Applicable

All sequences(174) RefSeq(28) UniProt(37)

Polymorphisms

RFLP(1) : SNPs within 2kb(1350 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology	PR:000016176	transcription factor 12

References

(Earliest) J:18120 Sun XH, et al., Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol. 1991 Nov;11(11):5603-11
(Latest) J:209824 D'Cruz LM, et al., E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation. J Immunol. 2014 Mar 1;192(5):2227-36
All references(97)

Other
accession IDs

MGD-MRK-18703