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Tcf12
Gene Detail
Symbol

Name
ID
Tcf12
transcription factor 12
MGI:101877
Synonyms
ALF1, bHLHb20, HEB, HEBAlt, HTF4, HTF-4, ME1, REB
Feature Type
protein coding gene
Genetic Map
Chromosome 9
39.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr9:71842688-72111871 bp, - strand
From VEGA annotation of GRCm38

  269184 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TCF12
Protein SuperFamily: transcription factor 3
Gene Tree: Tcf12

Human
homologs
TCF12, transcription factor 12
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6938
neXtProt AC: NX_Q99081

Human Synonyms: bHLHb20, CRS3, HEB, HsT17266, HTF4, TCF-12

Human Chr (Location): 15q21; chr15:56918289-57291129 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TCF12

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(35) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation exhibit postnatal lethality within two weeks of birth and a 50% reduction in the number of pro-B cells.
 
Interactions
Tcf12 interacts with 432 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process cell differentiation, multicellular organismal development, ...
Component cytoplasm, nuclear chromatin, ...
Function bHLH transcription factor binding, cAMP response element binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (299)    Tissues (230)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 272
Northern blot 9
RT-PCR 18
cDNA source data(247)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TCF12 ; Xenbase tcf12 ; ZFIN tcf12    NEW 
Molecular
reagents
All nucleic(255) Genomic(1) cDNA(248) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000044751 (Evidence)
Ensembl Gene Model ENSMUSG00000032228 (Evidence)
Entrez Gene 21406 (Evidence)
UniGene 171615
DFCI TC1578733, TC1583480, TC1671446, TC1585952, TC1627947
DoTS DT.101249727, DT.94224421, DT.101394004, DT.99857779, DT.55252504, DT.91576903, DT.55257388, DT.55261901
NIA Mouse Gene Index U031072
Consensus CDS Project CCDS23329.1, CCDS72271.1, CCDS72272.1
International Mouse Phenotyping Consortium Status Tcf12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044751 VEGA Gene Model | MGI Sequence Detail 269184 C57BL/6J ±  kb
transcript OTTMUST00000117656 VEGA | MGI Sequence Detail 6299 Not Applicable 
polypeptide OTTMUSP00000065761 VEGA | MGI Sequence Detail 706 Not Applicable 

For the selected sequences
All sequences(156) RefSeq(28) UniProt(19)
Polymorphisms
RFLP(1) : SNPs within 2kb(1350 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000016176 transcription factor 12
References
(Earliest) J:18120 Sun XH, et al., Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol. 1991 Nov;11(11):5603-11
(Latest) J:209824 D'Cruz LM, et al., E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation. J Immunol. 2014 Mar 1;192(5):2227-36
All references(96)
Other
accession IDs
MGD-MRK-18703

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory