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Dag1
Gene Detail
Symbol

Name
ID
Dag1
dystroglycan 1
MGI:101864
STS
Synonyms
alpha-dystroglycan, beta-dystroglycan, D9Wsu13e, DG, dystrophin associated glycoprotein 1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
59.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr9:108204634-108263958 bp, - strand
From VEGA annotation of GRCm38

  59325 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3234  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dystroglycan 1
Gene Tree: Dag1

Human
homologs
Human Homolog   DAG1, dystroglycan 1 (dystrophin-associated glycoprotein 1)
NCBI Gene ID 1605
neXtProt AC  NX_Q14118
Human Synonyms  156DAG, A3a, AGRNR, DAG, MDDGC7, MDDGC9
Human Chr (Location)  3p21; chr3:49468703-49535618 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DAG1
Mutations,
alleles, and
phenotypes
All mutations/alleles(106) : Gene trapped(96) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutant embryos show gross abnormalities, particularly defective Reichert's membrane by 6.5 days, indicating a possible role for this gene product in basement membrane organization.
 
Human Diseases Modeled in Mice Using Dag1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Dag1 interacts with 304 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (44 records)
Data Summary: Results (300)    Tissues (174)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 114
RNA in situ 82
Western blot 6
RT-PCR 98
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) Genomic(6) cDNA(19) Primer pair(3) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000050793 (Evidence)
Ensembl Gene ModelENSMUSG00000039952 (Evidence)
Entrez Gene13138 (Evidence)
DFCITC1604270, TC1624234, TC1644113, TC1652361, TC1572275, TC1602610
DoTSDT.110584026, DT.110584023, DT.110584047, DT.55107569, DT.91287652, DT.97384966, DT.91350564, DT.94379768
NIA Mouse Gene IndexU031332
PDB1U2C
Consensus CDS ProjectCCDS23518.1
International Mouse Knockout Project StatusDag1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050793 VEGA Gene Model | MGI Sequence Detail 59325 C57BL/6J ±  kb
transcript OTTMUST00000128733 VEGA | MGI Sequence Detail 5662 Not Applicable 
polypeptide OTTMUSP00000069235 VEGA | MGI Sequence Detail 893 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(18) UniProt(6)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027468 Alpha-dystroglycan domain 2
InterPro IPR015919 Cadherin-like
InterPro IPR008465 Dystroglycan
InterPro IPR006644 Dystroglycan-type cadherin-like
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000006267 dystroglycan
References
(Earliest) J:1875 Ohlendieck K, et al., Dystrophin-associated proteins are greatly reduced in skeletal muscle from mdx mice. J Cell Biol. 1991 Dec;115(6):1685-94
(Latest) J:217403 Menezes MJ, et al., The extracellular matrix protein laminin alpha2 regulates the maturation and function of the blood-brain barrier. J Neurosci. 2014 Nov 12;34(46):15260-80
All references(157)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-18689, MGD-MRK-34097

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory