Phenotypes Associated with This Genotype

Genotype
MGI:4946226

• Allelic Composition: Dag1^tm2Kcam/Dag1^tm2Kcam; Myl2^tm1(cre)Krc/Myl2⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

myocardial fiber degeneration ( J:169951 )

• myocardial cell degeneration marked by eosinophilic myocytes, infiltration of mononuclear cells and significant focal collagen deposition at 10 months of age

• mutants exhibit focal patches of cardiac myocyte membrane damage due to damage expansion of myocardial damage to neighboring myocytes, compared to controls that only show damage in individual myocytes

abnormal heart left ventricle wall thickness ( J:169951 )

• some hearts exhibit focal thinning of the left ventricular wall

cardiac fibrosis ( J:169951 )

• increase in cardiac fibrosis, with nearly 9% of the myocardium replaced with focal fibrotic tissue at 10 months of age

dilated cardiomyopathy ( J:169951 )

• mutants develop progressive dilated cardiomyopathy

• 65% increase in heart weight/body weight ratios

• ratio of the end diastolic volume to mass is increased, indicating dilation of chambers as opposed to increase in overall heart size

• first signs of cardiomyopathy are seen at 7 months of age, with mutants starting to show small focal areas of fibrosis

abnormal cardiac muscle contractility ( J:169951 )

• reduction in the left ventricular ejection fraction indicating impaired systolic function

muscle

myocardial fiber degeneration ( J:169951 )

• myocardial cell degeneration marked by eosinophilic myocytes, infiltration of mononuclear cells and significant focal collagen deposition at 10 months of age

• mutants exhibit focal patches of cardiac myocyte membrane damage due to damage expansion of myocardial damage to neighboring myocytes, compared to controls that only show damage in individual myocytes

dilated cardiomyopathy ( J:169951 )

• mutants develop progressive dilated cardiomyopathy

• 65% increase in heart weight/body weight ratios

• ratio of the end diastolic volume to mass is increased, indicating dilation of chambers as opposed to increase in overall heart size

• first signs of cardiomyopathy are seen at 7 months of age, with mutants starting to show small focal areas of fibrosis

abnormal cardiac muscle contractility ( J:169951 )

• reduction in the left ventricular ejection fraction indicating impaired systolic function

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:169951