Tbp
Gene Detail

Symbol Name ID

Tbp TATA box binding protein MGI:101838

Synonyms

Gtf2d

Feature Type

protein coding gene

Genetic Map

Chromosome 17

8.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr17:15499888-15528379 bp, + strand From VEGA annotation of GRCm38   28492 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2404  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tbp

Human homologs

Human Homolog		TBP, TATA box binding protein
NCBI Gene ID		6908
neXtProt AC		NX_P20226
Human Synonyms		GTF2D, GTF2D1, HDL4, SCA17, TFIID
Human Chr (Location)		6q27; chr6:170863421-170881958 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human TBP

Alleles and phenotypes

All alleles(14) : Targeted(5) Gene trapped(9)
 

Mice homozygous for one null allele exhibit embryonic lethality caused by hemorrhaging and clotting in the placenta and surviving embryos die prior to weaning. Mice homozygous for another null allele undergo growth arrest after hatching and apoptosis.

 

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	DNA-dependent transcription, initiation, positive regulation of transcription, DNA-dependent, ...
Component	cytoplasm, female pronucleus, ...
Function	DNA binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (35 records)
Data Summary: Results (232)    Tissues (191)    Images (29)
Theiler Stages: 1, 2, 3, 4, 5, 13, 15, 17, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	161
Western blot	4
RT-PCR	67

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) Genomic(13) cDNA(19) Primer pair(6) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000030550 (Evidence)
Ensembl Gene Model	ENSMUSG00000014767 (Evidence)
Entrez Gene	21374 (Evidence)
Consensus CDS Project	CCDS37454.2
International Mouse Knockout Project Status	Tbp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030550	VEGA Gene Model | MGI Sequence Detail	28492	C57BL/6J
transcript	OTTMUST00000075644	VEGA | MGI Sequence Detail	12794	Not Applicable
polypeptide	OTTMUSP00000039699	VEGA | MGI Sequence Detail	316	Not Applicable

All sequences(70) RefSeq(2) UniProt(11)

Polymorphisms

RFLP(2) : SNPs(67 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012295	Beta2-adaptin/TBP, C-terminal domain
InterPro	IPR000814	TATA-box binding protein
Protein Ontology	PR:000016137	TATA-box-binding protein

References

(Earliest) J:21431 Tamura T, et al., Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID). Nucleic Acids Res. 1991 Jul 25;19(14):3861-5
(Latest) J:183633 Plessy C, et al., Promoter architecture of mouse olfactory receptor genes. Genome Res. 2012 Mar;22(3):486-97
All references(98)

Other accession IDs

MGD-MRK-18659, MGD-MRK-24009