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Tbp Gene Detail
Summary
  • Symbol
    Tbp
  • Name
    TATA box binding protein
  • Synonyms
    Gtf2d
  • Feature Type
    protein coding gene
  • IDs
    MGI:101838
    NCBI Gene: 21374
  • Gene Overview
    MyGene.info: TBP
Location & Maps
more
  • Sequence Map
    Chr17:15499888-15528379 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28492 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.95 cM
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    TBP, TATA-box binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TBP, TATA-box binding protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GTF2D, GTF2D1, HDL4, SCA17, TFIID
  • Links
    NCBI Gene ID: 6908
    neXtProt AC: NX_P20226

  • Chr Location
    6q27; chr6:170554333-170572870 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2404
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: TBP
  • Gene Tree
    Tbp
Human Diseases
more
  • Diseases
    1 with Tbp mouse models; 2 with human TBP associations

Human Disease Mouse Models
       Spinocerebellar Ataxia 17; SCA17   OMIM: 607136 View 5 models
       Parkinson Disease, Late-Onset; PD   OMIM: 168600
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 5 genetic backgrounds
    42 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Gene trapped
    9
  • Targeted
    8
  • Transgenic
    5
  • Incidental Mutations
Mice homozygous for one null allele exhibit embryonic lethality caused by hemorrhaging and clotting in the placenta and surviving embryos die prior to weaning. Mice homozygous for another null allele undergo growth arrest after hatching and apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030550 VEGA Gene Model | MGI Sequence Detail 28492 C57BL/6J ±  kb
transcript OTTMUST00000075644 VEGA | MGI Sequence Detail 12794 Not Applicable  
polypeptide OTTMUSP00000039699 VEGA | MGI Sequence Detail 316 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    157 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000016137 TATA-box-binding protein
  • InterPro Domains
    IPR012295 Beta2-adaptin/TBP, C-terminal domain
    IPR000814 TATA-box binding protein
    IPR030491 TATA-box binding protein, conserved site
Molecular
Reagents
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  • All nucleic 41
    Genomic 13
    cDNA 19
    Primer pair 7
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-18659, MGD-MRK-24009
References
more
  • Summaries
    All 109
    Developmental Gene Expression 42
    Diseases 4
    Gene Ontology 26
    Phenotypes 16
  • Earliest
    J:21431 Tamura T, et al., Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID). Nucleic Acids Res. 1991 Jul 25;19(14):3861-5
  • Latest
    J:233096 Childress P, et al., Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis. Mol Endocrinol. 2015 Sep;29(9):1269-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory