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Tbp Gene Detail
Summary
  • Symbol
    Tbp
  • Name
    TATA box binding protein
  • Synonyms
    Gtf2d
  • Feature Type
    protein coding gene
  • IDs
    MGI:101838
    NCBI Gene: 21374
  • Gene Overview
    MyGene.info: TBP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:15499888-15528379 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28492 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.95 cM
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    TBP, TATA-box binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TBP, TATA-box binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GTF2D, GTF2D1, HDL4, SCA17, TFIID
  • Links
    NCBI Gene ID: 6908
    neXtProt AC: NX_P20226
    UniProt: P20226

  • Chr Location
    6q27; chr6:170554333-170572870 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2404
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TBP
  • Gene Tree
    Tbp
Human Diseases
more
  • Diseases
    1 with Tbp mouse models; 2 with human TBP associations

Human Disease Mouse Models
      
IDs
View 5 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 5 genetic backgrounds
    42 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit embryonic lethality caused by hemorrhaging and clotting in the placenta and surviving embryos die prior to weaning. Mice homozygous for another null allele undergo growth arrest after hatching and apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030550 VEGA Gene Model | MGI Sequence Detail 28492 C57BL/6J ±  kb
    transcript OTTMUST00000075644 VEGA | MGI Sequence Detail 12794 Not Applicable  
    polypeptide OTTMUSP00000039699 VEGA | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      157 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 13
      cDNA 21
      Primer pair 8
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18659, MGD-MRK-24009
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 43
      Diseases 3
      Gene Ontology 27
      Phenotypes 17
    • Earliest
      J:21431 Tamura T, et al., Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID). Nucleic Acids Res. 1991 Jul 25;19(14):3861-5
    • Latest
      J:248996 Yang Y, et al., Synergistic Toxicity of Polyglutamine-Expanded TATA-Binding Protein in Glia and Neuronal Cells: Therapeutic Implications for Spinocerebellar Ataxia 17. J Neurosci. 2017 Sep 20;37(38):9101-9115

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory