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Tbp
Gene Detail
Symbol

Name
ID
Tbp
TATA box binding protein
MGI:101838
Synonyms
Gtf2d
Feature Type
protein coding gene
Genetic Map
Chromosome 17
8.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr17:15499888-15528379 bp, + strand
From VEGA annotation of GRCm38

  28492 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Tbp
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(9) Targeted(6)
 
Mice homozygous for one null allele exhibit embryonic lethality caused by hemorrhaging and clotting in the placenta and surviving embryos die prior to weaning. Mice homozygous for another null allele undergo growth arrest after hatching and apoptosis.
 
Interactions
Tbp interacts with 605 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process DNA-templated transcription, initiation, regulation of transcription, DNA-templated, ...
Component cytoplasm, female pronucleus, ...
Function DNA binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (225)    Tissues (188)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 161
Western blot 4
RT-PCR 60
cDNA source data(12)
External Resources: Allen Institute   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(13) cDNA(14) Primer pair(6) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000030550 (Evidence)
Ensembl Gene ModelENSMUSG00000014767 (Evidence)
Entrez Gene102639613, 21374
NIA Mouse Gene IndexU017529
Consensus CDS ProjectCCDS37454.2
International Mouse Knockout Project StatusTbp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030550 VEGA Gene Model | MGI Sequence Detail 28492 C57BL/6J ±  kb
transcript OTTMUST00000075644 VEGA | MGI Sequence Detail 12794 Not Applicable 
polypeptide OTTMUSP00000039699 VEGA | MGI Sequence Detail 316 Not Applicable 

For the selected sequences
All sequences(68) UniProt(17)
Polymorphisms
RFLP(2) : SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012295 Beta2-adaptin/TBP, C-terminal domain
InterPro IPR000814 TATA-box binding protein
Protein Ontology PR:000016137 TATA-box-binding protein
References
(Earliest) J:21431 Tamura T, et al., Striking homology of the 'variable' N-terminal as well as the 'conserved core' domains of the mouse and human TATA-factors (TFIID). Nucleic Acids Res. 1991 Jul 25;19(14):3861-5
(Latest) J:209773 Gewies A, et al., Prdm6 is essential for cardiovascular development in vivo. PLoS One. 2013;8(11):e81833
All references(102)
Other
accession IDs
MGD-MRK-18659, MGD-MRK-24009

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory