About   Help   FAQ
Mybl2
Gene Detail
Symbol

Name
ID
Mybl2
myeloblastosis oncogene-like 2
MGI:101785
Synonyms
Bmyb, B-Myb
Feature Type
protein coding gene
Genetic Map
Chromosome 2
84.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:163054687-163084688 bp, + strand
From VEGA annotation of GRCm38

  30002 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1847  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYBL2
Protein SuperFamily: Myb transforming protein
Gene Tree: Mybl2

Human
homologs
MYBL2, v-myb avian myeloblastosis viral oncogene homolog-like 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4605
neXtProt AC: NX_P10244

Human Synonyms: BMYB, B-MYB

Human Chr (Location): 20q13.1; chr20:43667019-43716496 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(213) : Gene trapped(204) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die as embryos shortly after implantation.
 
Human Diseases Modeled in Mice Using Mybl2 (2)    Mutations Annotated to Human Diseases (1)   
Interactions
Mybl2 interacts with 161 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell cycle, mitotic spindle assembly, ...
Component Myb complex, nucleoplasm, ...
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (346)    Tissues (87)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 302
RT-PCR 44
cDNA source data(112)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mybl2 ; ZFIN mybl2a, mybl2b    NEW 
Molecular
reagents
All nucleic(115) cDNA(112) Primer pair(3)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000001166 (Evidence)
Ensembl Gene Model ENSMUSG00000017861 (Evidence)
Entrez Gene 17865 (Evidence)
UniGene 4594
DFCI TC1752925, TC1744284, TC1574940
DoTS DT.94219033, DT.94219034, DT.532425, DT.110705329
NIA Mouse Gene Index U002779, U095436, U165175
PDB 2D9A
Consensus CDS Project CCDS17006.1
International Mouse Phenotyping Consortium Status Mybl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001166 VEGA Gene Model | MGI Sequence Detail 30002 C57BL/6J ±  kb
transcript OTTMUST00000002262 VEGA | MGI Sequence Detail 3651 Not Applicable 
polypeptide OTTMUSP00000001107 VEGA | MGI Sequence Detail 704 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(12) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(171 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015395 C-myb, C-terminal
InterPro IPR009057 Homeodomain-like
InterPro IPR017930 Myb domain
InterPro IPR001005 SANT/Myb domain
Protein Ontology PR:000010802 myb-related protein B
References
(Earliest) J:2269 Lam EW, et al., Characterization and cell cycle-regulated expression of mouse B-myb. Oncogene. 1992 Sep;7(9):1885-90
(Latest) J:206816 Baker SJ, et al., B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3122-7
All references(63)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-18593

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory