Serpine2
Gene Detail

Symbol Name ID

Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 MGI:101780

Synonyms

B230326M24Rik, nexin, PI7, PN-1, protease nexin 1, Spi4

Feature Type

protein coding gene

Genetic Map

Chromosome 1

40.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:79794197-79858696 bp, - strand From VEGA annotation of GRCm38   64500 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpine2

Human homologs

Human Homolog		SERPINE2, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
NCBI Gene ID		5270
neXtProt AC		NX_P07093
Human Synonyms		GDN, GDNPF, PI7, PI-7, PN1, PN-1, PNI
Human Chr (Location)		2q36.1; chr2:224839765-224904036 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for a targeted mutation of this gene are viable and healthy but develop epileptic activity as well as reduced theta burst-induced LTP and NMDA receptor-mediated synaptic transmission in the CA1 field of the hippocampus; notably, homozygous mutant males are infertile.

 

Gene Ontology (GO) classifications

All GO classifications: (64 annotations)

Process	blood coagulation, cell differentiation, ...
Component	cytosol, extracellular matrix, ...
Function	glycosaminoglycan binding, heparin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (372)    Tissues (83)    Images (29)
Theiler Stages: 15, 17, 18, 19, 20, 21, 22, 23

Assay Type	Results
RNA in situ	328
RT-PCR	44

cDNA source data(149)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(156) Genomic(1) cDNA(152) Primer pair(1) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021751 (Evidence)
Ensembl Gene Model	ENSMUSG00000026249 (Evidence)
Entrez Gene	20720 (Evidence)
UniGene	3093
DFCI	TC1572052
DoTS	DT.101405545, DT.101712051, DT.533874
NIA Mouse Gene Index	U021518
Consensus CDS Project	CCDS15092.1
International Mouse Knockout Project Status	Serpine2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021751	VEGA Gene Model | MGI Sequence Detail	64500	C57BL/6J
transcript	OTTMUST00000051625	VEGA | MGI Sequence Detail	2210	Not Applicable
polypeptide	OTTMUSP00000024336	VEGA | MGI Sequence Detail	397	Not Applicable

All sequences(33) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(401 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000014703	glia-derived nexin

References

(Earliest) J:161338 Festoff BW, et al., Plasminogen activators and inhibitors in the neuromuscular system: III. The serpin protease nexin I is synthesized by muscle and localized at neuromuscular synapses. J Cell Physiol. 1991 Apr;147(1):76-86
(Latest) J:183799 Selbonne S, et al., In vitro and in vivo antiangiogenic properties of the serpin protease nexin-1. Mol Cell Biol. 2012 Apr;32(8):1496-505
All references(71)

Other accession IDs

MGD-MRK-18588, MGI:2443859