Cd79a
Gene Detail

Symbol Name ID

Cd79a CD79A antigen (immunoglobulin-associated alpha) MGI:101774

STS

D7Mit20, D7Mit24

Synonyms

Cd79a, Iga, Igalpha, Ig alpha, Ig-alpha, Ly54, Ly-54, mb-1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

13.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:24897381-24902197 bp, + strand From VEGA annotation of GRCm38   4817 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Cd79a ± 2 cM)

Gene Tree: Cd79a

Human ortholog

CD79A CD79a molecule, immunoglobulin-associated alpha NCBI Gene ID 973
Human Synonyms: IGA, MB-1
Human Chr19:42381190-42385439 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human CD79A (1)

Alleles and phenotypes

All alleles(19) : Targeted(16) Gene trapped(1) Chemically induced(2)
 

Homozygotes for targeted null mutations exhibit arrested development of B cells at the pro-B cell stage due to diminished signaling of the B cell receptor.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	B cell activation, B cell differentiation, ...
Component	B cell receptor complex, external side of plasma membrane, ...
Function	protein binding, transmembrane signaling receptor activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (9)    Tissues (2)   
Theiler Stages: 22, 23

Assay Type	Results
RT-PCR	9

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(50) Genomic(7) cDNA(41) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000029270 (Evidence)
Ensembl Gene Model	ENSMUSG00000003379 (Evidence)
Entrez Gene	12518 (Evidence)
UniGene	1355
DFCI	TC1581051
DoTS	DT.532982
NIA Mouse Gene Index	U007811
Consensus CDS Project	CCDS20967.1
International Mouse Knockout Project Status	Cd79a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029270	VEGA Gene Model | MGI Sequence Detail	4817	C57BL/6J
transcript	OTTMUST00000072520	VEGA | MGI Sequence Detail	1457	Not Applicable
polypeptide	OTTMUSP00000037360	VEGA | MGI Sequence Detail	220	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(12 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003110	Phosphorylated immunoreceptor signaling ITAM
Protein Ontology	PR:000001285	B-cell antigen receptor complex-associated protein alpha chain

References

(Earliest) J:9526 Sakaguchi N, et al., B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties. EMBO J. 1988 Nov;7(11):3457-64
(Latest) J:192606 Park SY, et al., Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments. J Immunol. 2013 Feb 1;190(3):1094-102
All references(130)

Other accession IDs

MGD-MRK-11997, MGD-MRK-12040, MGD-MRK-18581