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Cd79a Gene Detail
Summary
  • Symbol
    Cd79a
  • Name
    CD79A antigen (immunoglobulin-associated alpha)
  • Synonyms
    Cd79a, Iga, Igalpha, Ig alpha, Ig-alpha, Ly54, Ly-54, mb-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101774
    NCBI Gene: 12518
  • Gene Overview
    MyGene.info: CD79A
Location & Maps
more
  • Sequence Map
    Chr7:24897381-24902197 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4817 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.49 cM
  • Mapping Data
    1 experiment
  • Sequence Tags
Homology
more
  • Human Ortholog
    CD79A, CD79a molecule
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CD79A, CD79a molecule
    Orthology source: HomoloGene
  • Synonyms
    IGA, MB-1
  • Links
    NCBI Gene ID: 973
    neXtProt AC: NX_P11912

  • Chr Location
    19q13.2; chr19:41877120-41881372 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CD79A associations

Human Disease Mouse Models
       Agammaglobulinemia 3, Autosomal Recessive; AGM3   OMIM: 613501
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 16 alleles in 14 genetic backgrounds
    100 phenotypes from multigenic genotypes
    1 images
    142 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (ENU)
    2
  • Gene trapped
    1
  • Targeted
    17
  • Transgenic
    1
  • Incidental Mutations
    APF , CvDC
Homozygotes for targeted null mutations exhibit arrested development of B cells at the pro-B cell stage due to diminished signaling of the B cell receptor.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029270 VEGA Gene Model | MGI Sequence Detail 4817 C57BL/6J ±  kb
transcript OTTMUST00000072520 VEGA | MGI Sequence Detail 1457 Not Applicable  
polypeptide OTTMUSP00000037360 VEGA | MGI Sequence Detail 220 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    14 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001285 B-cell antigen receptor complex-associated protein alpha chain
  • InterPro Domains
    IPR013151 Immunoglobulin
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003110 Phosphorylated immunoreceptor signalling ITAM
Molecular
Reagents
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  • All nucleic 50
    Genomic 7
    cDNA 41
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11997, MGD-MRK-12040, MGD-MRK-18581
References
more
  • Summaries
    All 181
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 142
  • Earliest
    J:9526 Sakaguchi N, et al., B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties. EMBO J. 1988 Nov;7(11):3457-64
  • Latest
    J:231921 Pang SH, et al., PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia. Leukemia. 2016 Jun;30(6):1375-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory