About   Help   FAQ
Cd79a Gene Detail
Summary
  • Symbol
    Cd79a
  • Name
    CD79A antigen (immunoglobulin-associated alpha)
  • Synonyms
    Cd79a, Iga, Igalpha, Ig alpha, Ig-alpha, Ly54, Ly-54, mb-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101774
    NCBI Gene: 12518
  • Gene Overview
    MyGene.info: CD79A
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24897511-24902197 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.49 cM
  • Mapping Data
    1 experiment
  • Sequence Tags
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101774
protein coding gene Chr7:24897381-24902197 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031847
protein coding gene Chr7:23307459-23312275 (+)
A/J MGP_AJ_G0031826
protein coding gene Chr7:22735367-22740183 (+)
AKR/J MGP_AKRJ_G0031755
protein coding gene Chr7:23267990-23272806 (+)
BALB/cJ MGP_BALBcJ_G0031834
protein coding gene Chr7:22939973-22944789 (+)
C3H/HeJ MGP_C3HHeJ_G0031552
protein coding gene Chr7:23681706-23686522 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032295
protein coding gene Chr7:24081439-24086379 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029350
protein coding gene Chr7:24168134-24172888 (+)
CAST/EiJ MGP_CASTEiJ_G0030892
protein coding gene Chr7:17159930-17164756 (+)
CBA/J MGP_CBAJ_G0031517
protein coding gene Chr7:24969415-24974231 (+)
DBA/2J MGP_DBA2J_G0031671
protein coding gene Chr7:22640424-22645240 (+)
FVB/NJ MGP_FVBNJ_G0031624
protein coding gene Chr7:22619315-22624131 (+)
LP/J MGP_LPJ_G0031750
protein coding gene Chr7:23620002-23624818 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031661
protein coding gene Chr7:24704802-24709609 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032327
protein coding gene Chr7:22965597-22970413 (+)
PWK/PhJ MGP_PWKPhJ_G0030616
protein coding gene Chr7:17568215-17573036 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030447
protein coding gene Chr7:14279053-14283798 (+)
WSB/EiJ MGP_WSBEiJ_G0030996
protein coding gene Chr7:23128753-23133569 (+)



Homology
more
  • Human Ortholog
    CD79A, CD79a molecule
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CD79A, CD79a molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IGA, MB-1
  • Links
    NCBI Gene ID: 973
    neXtProt AC: NX_P11912
    UniProt: P11912

  • Chr Location
    19q13.2; chr19:41877120-41881372 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CD79A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 17 alleles in 15 genetic backgrounds
    109 phenotypes from multigenic genotypes
    1 images
    212 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit arrested development of B cells at the pro-B cell stage due to diminished signaling of the B cell receptor.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12518 NCBI Gene Model | MGI Sequence Detail 4687 C57BL/6J ±  kb
    transcript NM_007655 RefSeq | MGI Sequence Detail 1002 C57BL/6  
    polypeptide P11911 UniProt | EBI | MGI Sequence Detail 220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 7
      cDNA 42
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11997, MGD-MRK-12040, MGD-MRK-18581
    References
    more
    • Summaries
      All 267
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 14
      Phenotypes 212
    • Earliest
      J:9526 Sakaguchi N, et al., B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties. EMBO J. 1988 Nov;7(11):3457-64
    • Latest
      J:265645 Stark AK, et al., PI3Kdelta hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner. Nat Commun. 2018 Aug 9;9(1):3174

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory