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Cd79a
Gene Detail
Symbol

Name
ID
Cd79a
CD79A antigen (immunoglobulin-associated alpha)
MGI:101774
Synonyms
Cd79a, Iga, Igalpha, Ig alpha, Ig-alpha, Ly54, Ly-54, mb-1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:24897381-24902197 bp, + strand
From VEGA annotation of GRCm38

  4817 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CD79A
Gene Tree: Cd79a

Human
homologs
CD79A, CD79a molecule, immunoglobulin-associated alpha
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 973
neXtProt AC: NX_P11912

Human Synonyms: IGA, MB-1

Human Chr (Location): 19q13.2; chr19:41877120-41881372 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CD79A

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Chemically induced (ENU)(2) Gene trapped(1) Targeted(17)
Incidental mutations (data from APF , CvDC )
 
Homozygotes for targeted null mutations exhibit arrested development of B cells at the pro-B cell stage due to diminished signaling of the B cell receptor.
 
Phenotype Images(1)
Interactions
Cd79a interacts with 119 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (9)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 9
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cd79a    NEW 
Molecular
reagents
All nucleic(50) Genomic(7) cDNA(41) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029270 (Evidence)
Ensembl Gene Model ENSMUSG00000003379 (Evidence)
Entrez Gene 12518 (Evidence)
UniGene 1355
DFCI TC1581051
DoTS DT.532982
NIA Mouse Gene Index U007811
Consensus CDS Project CCDS20967.1
International Mouse Phenotyping Consortium Status Cd79a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029270 VEGA Gene Model | MGI Sequence Detail 4817 C57BL/6J ±  kb
transcript OTTMUST00000072520 VEGA | MGI Sequence Detail 1457 Not Applicable 
polypeptide OTTMUSP00000037360 VEGA | MGI Sequence Detail 220 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003110 Phosphorylated immunoreceptor signalling ITAM
Protein Ontology PR:000001285 B-cell antigen receptor complex-associated protein alpha chain
References
(Earliest) J:9526 Sakaguchi N, et al., B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties. EMBO J. 1988 Nov;7(11):3457-64
(Latest) J:222314 Konigsberger S, et al., Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms. Eur J Immunol. 2015 Feb;45(2):603-11
All references(170)
Other
accession IDs
MGD-MRK-11997, MGD-MRK-12040, MGD-MRK-18581

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory