Sequence Detail

ID/Version

P11911 Q6GTY0 (UniProt | EBI)

Last sequence update: 2007-07-24
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=B-cell antigen receptor complex-associated protein alpha chain;AltName: Full=Ig-alpha;AltName: Full=MB-1 membrane glycoprotein;AltName: Full=Membrane-bound immunoglobulin-associated protein;AltName: Full=Surface IgM-associated protein;AltNam

Provider

SWISS-PROT

Sequence

Polypeptide 220 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cd79a	CD79A antigen (immunoglobulin-associated alpha)	20	98	3	28

Sequence references in MGI

J:9526 Sakaguchi N, et al., B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties. EMBO J. 1988 Nov;7(11):3457-64
J:10573 Kashiwamura S, et al., Structure of the murine mb-1 gene encoding a putative sIgM-associated molecule. J Immunol. 1990 Jul 1;145(1):337-43
J:17868 Clark MR, et al., Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. EMBO J. 1994 Apr 15;13(8):1911-9
J:71100 Kraus M, et al., Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail. J Exp Med. 2001 Aug 20;194(4):455-69
J:87492 Pelanda R, et al., B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-alpha and Ig-beta. J Immunol. 2002 Jul 15;169(2):865-72
J:96419 Fuentes-Panana EM, et al., Ig alpha/Ig beta complexes generate signals for B cell development independent of selective plasma membrane compartmentalization. J Immunol. 2005 Feb 1;174(3):1245-52
J:110760 Torres RM, et al., A negative regulatory role for Ig-alpha during B cell development. Immunity. 1999 Nov;11(5):527-36
J:113407 Patterson HC, et al., The B cell receptor promotes B cell activation and proliferation through a non-ITAM tyrosine in the Igalpha cytoplasmic domain. Immunity. 2006 Jul;25(1):55-65
J:117076 Storch B, et al., The Ig-alpha ITAM is required for efficient differentiation but not proliferation of pre-B cells. Eur J Immunol. 2007 Jan;37(1):252-260
J:124754 Cheng PC, et al., Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling. J Immunol. 2001 Mar 15;166(6):3693-701
J:124758 Cheng PC, et al., A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J Exp Med. 1999 Dec 6;190(11):1549-60
J:159179 Infantino S, et al., Arginine methylation of the B cell antigen receptor promotes differentiation. J Exp Med. 2010 Apr 12;207(4):711-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89