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Hmga2 Gene Detail
Summary
  • Symbol
    Hmga2
  • Name
    high mobility group AT-hook 2
  • Synonyms
    9430083A20Rik, Hmgic, HMGI-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:101761
    NCBI Gene: 15364
  • Gene Overview
    MyGene.info: HMGA2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:120361275-120476469 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      115195 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 67.94 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    HMGA2, high mobility group AT-hook 2
  • Vertebrate Orthologs
    5
  • Human Ortholog
    HMGA2, high mobility group AT-hook 2
    Orthology source: HGNC
  • Synonyms
    BABL, HMGIC, HMGI-C, LIPO, STQTL9
  • Links
    NCBI Gene ID: 8091
    neXtProt AC: NX_P52926
    UniProt: P52926

  • Chr Location
    12q14.3; chr12:65824460-65966291 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human HMGA2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    23 phenotypes from multigenic genotypes
    2 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for null mutations exhibit proportionate dwarfing with a significant reduction in body weight, reduced amounts of fat tissue, and infertility in both sexes. Mutants have normal growth hormone levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033206 VEGA Gene Model | MGI Sequence Detail 115195 C57BL/6J ±  kb
    transcript OTTMUST00000083150 VEGA | MGI Sequence Detail 3810 Not Applicable  
    polypeptide OTTMUSP00000044631 VEGA | MGI Sequence Detail 129 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      465 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 172
      Genomic 13
      cDNA 147
      Primer pair 5
      Other 7

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13252, MGD-MRK-18567, MGI:1924607
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 36
      Diseases 1
      Gene Ontology 24
      Phenotypes 38
    • Earliest
      J:25351 Macarthur JW, Genetics of body size and related characters. Am Naturalist. 1944;78:142-57
    • Latest
      J:253978 Moon H, et al., Melanocyte Stem Cell Activation and Translocation Initiate Cutaneous Melanoma in Response to UV Exposure. Cell Stem Cell. 2017 Nov 2;21(5):665-678.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory