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Hmga2
Gene Detail
Symbol

Name
ID
Hmga2
high mobility group AT-hook 2
MGI:101761
Synonyms
9430083A20Rik, Hmgic, HMGI-C
Feature Type
protein coding gene
Genetic Map
Chromosome 10
67.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr10:120361275-120476469 bp, - strand
From VEGA annotation of GRCm38

  115195 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2602  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: nonhistone chromosomal protein HMG-I
Gene Tree: Hmga2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Spontaneous(1) Targeted(1) Transgenic(2)
 
Homozygotes for null mutations exhibit proportionate dwarfing with a significant reduction in body weight, reduced amounts of fat tissue, and infertility in both sexes. Mutants have normal growth hormone levels.
 
Phenotype Images(2)
Interactions
Hmga2 interacts with 400 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process adipose tissue development, adrenal gland development, ...
Component chromatin, nuclear chromosome, ...
Function AT DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (347)    Tissues (133)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 254
Northern blot 38
Western blot 7
RT-PCR 48
cDNA source data(147)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(170) Genomic(12) cDNA(147) Primer pair(5) Other(6)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000033206 (Evidence)
Ensembl Gene ModelENSMUSG00000056758 (Evidence)
Entrez Gene15364 (Evidence)
UniGene157190
DFCITC1628518, TC1575541, TC1594601, TC1613463
DoTSDT.91331302, DT.103574128, DT.487014
Consensus CDS ProjectCCDS36073.1
International Mouse Knockout Project StatusHmga2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033206 VEGA Gene Model | MGI Sequence Detail 115195 C57BL/6J ±  kb
transcript OTTMUST00000083150 VEGA | MGI Sequence Detail 3810 Not Applicable 
polypeptide OTTMUSP00000044631 VEGA | MGI Sequence Detail 129 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(2)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(473 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017956 AT hook, DNA-binding motif
InterPro IPR020478 AT hook-like
InterPro IPR000116 High mobility group, HMG-I/HMG-Y
Protein Ontology PR:000008629 high mobility group protein HMGI-C
References
(Earliest) J:25351 Macarthur JW, Genetics of body size and related characters. Am Naturalist. 1944;78:142-57
(Latest) J:218706 Lam K, et al., Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice. Blood. 2014 Oct 2;124(14):2203-12
All references(107)
Other
accession IDs
MGD-MRK-13252, MGD-MRK-18567, MGI:1924607

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory