About   Help   FAQ
Hmga2 Gene Detail
Summary
  • Symbol
    Hmga2
  • Name
    high mobility group AT-hook 2
  • Synonyms
    9430083A20Rik, Hmgic, HMGI-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:101761
    NCBI Gene: 15364
  • Alliance
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:120197180-120312374 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 67.94 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101761
protein coding gene Chr10:120197173-120312374 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017775
protein coding gene Chr10:123633019-123639023 (-)
A/J MGP_AJ_G0017750
protein coding gene Chr10:118634716-118752552 (-)
AKR/J MGP_AKRJ_G0017713
protein coding gene Chr10:122169858-122293605 (-)
BALB/cJ MGP_BALBcJ_G0017714
protein coding gene Chr10:119135408-119141401 (-)
C3H/HeJ MGP_C3HHeJ_G0017538
protein coding gene Chr10:122369429-122488624 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018169
protein coding gene Chr10:127820401-127827666 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015850
protein coding gene Chr10:113095295-113101519 (-)
CAST/EiJ MGP_CASTEiJ_G0017098
protein coding gene Chr10:122812719-122820607 (-)
CBA/J MGP_CBAJ_G0017507
protein coding gene Chr10:132912031-133051502 (-)
DBA/2J MGP_DBA2J_G0017613
protein coding gene Chr10:117878956-117884949 (-)
FVB/NJ MGP_FVBNJ_G0017608
protein coding gene Chr10:116753990-116868631 (-)
LP/J MGP_LPJ_G0017687
protein coding gene Chr10:124070280-124193920 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017637
protein coding gene Chr10:135631969-135637962 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018209
protein coding gene Chr10:122285859-122291861 (-)
PWK/PhJ MGP_PWKPhJ_G0016883
protein coding gene Chr10:117978750-117985051 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016674
protein coding gene Chr10:121067816-121190487 (-)
WSB/EiJ MGP_WSBEiJ_G0017159
protein coding gene Chr10:122417201-122541769 (-)



Homology
more
  • Human Ortholog
    HMGA2, high mobility group AT-hook 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGA2, high mobility group AT-hook 2
  • Synonyms
    BABL, HMGIC, HMGI-C, LIPO, SRS5, STQTL9
  • Links
    NCBI Gene ID: 8091
    neXtProt AC: NX_P52926
    UniProt: P52926

  • Chr Location
    12q14.3; chr12:65824460-65966291 (+)  GRCh38

Human Diseases
more
  • Diseases
    4 with human HMGA2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 4 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    2 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations exhibit proportionate dwarfing with a significant reduction in body weight, reduced amounts of fat tissue, and infertility in both sexes. Mutants have normal growth hormone levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056758 Ensembl Gene Model | MGI Sequence Detail 115195 C57BL/6J ±  kb
    transcript ENSMUST00000159699 Ensembl | MGI Sequence Detail 3810 Not Applicable  
    polypeptide ENSMUSP00000123998 Ensembl | MGI Sequence Detail 129 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 181
      Genomic 13
      cDNA 149
      Primer pair 9
      Other 10

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13252, MGD-MRK-18567, MGI:1924607
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 52
      Diseases 1
      Gene Ontology 26
      Phenotypes 45
    • Earliest
      J:25351 Macarthur JW, Genetics of body size and related characters. Am Naturalist. 1944;78:142-57
    • Latest
      J:340777 Laddach A, et al., A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia. Nat Commun. 2023 Sep 22;14(1):5904

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory