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Mapping Data
Experiment
  • Experiment
    TEXT-QTL
  • Chromosome
    1
  • Reference
    J:101842 Norkina O, et al., Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10. BMC Genet. 2005 May 27;6(1):29
  • ID
    MGI:3606276
Genes
GeneAlleleAssay TypeDescription
Cfmq1 visible phenotype
D1Mit36 PCR
Kcnj9 reported elsewhere
Kcnj10 reported elsewhere
Tnfsf4 reported elsewhere
Fasl reported elsewhere
Sele reported elsewhere
Sell reported elsewhere
Selp reported elsewhere
Slamf1 reported elsewhere
Cd48 reported elsewhere
Cd84 reported elsewhere
Slamf6 reported elsewhere
Slamf9 reported elsewhere
Xcl1 reported elsewhere
Fcgr2b reported elsewhere
Fcgr3 reported elsewhere
Fcer1g reported elsewhere
Fcer1a reported elsewhere
Tlr5 reported elsewhere
Notes
  • Experiment
    Modifiers of the cystic fibrosis (CF) phenotype were mapped to mouse Chromosomes 1, 9, and 10 using allele comparison between B6;129-Cftrtm1Unc and C57BL/6J-Cftrtm1Unc. 108 polymorphic loci at an average spacing of 12 cM - 13 cM were compared betweenthe 2 strains. B6;129-Cftrtm1Unc is a mixed line composed of 95% C57BL/6J and 5% 129X1/SvJ. Although B6;129-Cftrtm1Unc carries the Cftr mutation, these animals exhibit a mild cystic fibrosis phenotype (increased survival, reduced intestinal inflammation, near normal body weight, and reduced mucus accumulation in intestinal crypts) compared to C57BL/6J-Cftrtm1Unc.

    Linkage to the mild CF phenotype is linked to D1Mit36 (92.3 cM) on mouse Chromosome 1. This locus is named Cfmq1 (cystic fibrosis modifier QTL 1). Heterozygosity at Cfmq1 appears to confer milder CF traits. Potential candidate genes for Cfmq1 include Kcnj9 (94.2 cM), Kcnj10 (93.5 cM), Tnfsf4 (84.9 cM), Fasl (89 cM), Sele (86.6 cM), Sell (86.6 cM), Selp (86.6 cM), Slamf1 (93.3 cM),Cd48 (93.3 cM), Cd84 (93.3 cM), Slamf6 (89.5 cM), Slamf9, Xcl1 (87 cM), Fcgr2b (92.3 cM), Fcgr3 (92.3 cM), Fcer1g (93.3 cM), Fcer1a (94.2 cM), and Tlr5 (98 cM). Previously identified body weight QTL mapping near Cfmq1 are Cfbw1 (85 cM), Obq9 (88.4 cM), and Bw8q1 (100 cM).

    Linkage to the mild CF phenotype is linked to D9Mit90 (9 cM) on mouse Chromosome 9. This locus is named Cfmq2 (cystic fibrosis modifier QTL 2). Homozygosity for 129X1/SvJ-derived alleles at Cfmq2 appears to confer milder CF traits. Potential candidate genes for Cfmq2 include Kcnj5 (11 cM), Mmp3 (1 cM), and Mmp7 (1 cM). Previously identified body weight QTL mapping near Cfmq2 are Lbm6 (7.7 cM) and Bwtq4 (8 cM).

    Linkage to the mild CF phenotype is linked to D10Mit14 (65 cM) on mouse Chromosome 10. This locus is named Cfmq3 (cystic fibrosis modifier QTL 3). Heterozygosity at Cfmq3 appears to confer milder CF traits. Potential candidate genes for Cfmq3 include Kcnc2 (62 cM), Kitl (57 cM), Lyzs (66 cM), Ifng (67 cM), Il22 (67 cM), Stat2 (70 cM), and Stat6 (70 cM). Previously identified QTL mapping near Cfmq3 are Bgeq8 (57 cM), Pbwg5 (68 cM), and Im5 (65 cM).




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory