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Fcer1g Gene Detail
Summary
  • Symbol
    Fcer1g
  • Name
    Fc receptor, IgE, high affinity I, gamma polypeptide
  • Synonyms
    Fce1g, FcepsilonRI, FcR[g], FcR-gamma, FcRgamma, Ly-50
  • Feature Type
    protein coding gene
  • IDs
    MGI:95496
    NCBI Gene: 14127
  • Alliance
  • Transcription Start Sites
    25 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:171057141-171061918 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.23 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    14
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95496
protein coding gene Chr1:171057141-171061934 (-)
129S1/SvImJ ENSMUSG00200046234
protein coding gene Chr1:168541571-168546231 (-)
A/J ENSMUSG00195048025
protein coding gene Chr1:167896936-167901576 (-)
AKR/J ENSMUSG00220026283
protein coding gene Chr1:167641072-167645869 (-)
BALB/cJ ENSMUSG00180043991
protein coding gene Chr1:168181824-168186487 (-)
C3H/HeJ ENSMUSG00175040402
protein coding gene Chr1:168192926-168197586 (-)
C57BL/6NJ ENSMUSG00215044051
protein coding gene Chr1:168013942-168018733 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014858
protein coding gene Chr1:161491214-161495868 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210033834
protein coding gene Chr1:168071829-168076478 (-)
DBA/2J ENSMUSG00185027200
protein coding gene Chr1:172385771-172390418 (-)
FVB/NJ ENSMUSG00205033359
protein coding gene Chr1:167080928-167085582 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230024810
protein coding gene Chr1:171958689-171963347 (-)
NOD/ShiLtJ ENSMUSG00190031270
protein coding gene Chr1:167859050-167863696 (-)
NZO/HlLtJ ENSMUSG00225003693
protein coding gene Chr1:175580501-175585141 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    FCER1G, Fc epsilon receptor Ig
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCER1G, Fc epsilon receptor Ig
  • Synonyms
    FCRG
  • Links
    NCBI Gene ID: 2207
    UniProt: P30273

  • Chr Location
    1q23.3; chr1:161215234-161220699 (+)  GRCh38

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 3 alleles in 7 genetic backgrounds
    52 phenotypes from multigenic genotypes
    484 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impairments in macrophage phagocytosis, NK cell-mediated antibody-coated cytotoxicity, mast cell degranulation, IgE-mediated systemic anaphylaxis, and neutrophil recruitment and migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14127 NCBI Gene Model | MGI Sequence Detail 4778 C57BL/6J ±  kb
    transcript NM_010185 RefSeq | MGI Sequence Detail 683 ZRU/MplStud  
    polypeptide P20491 UniProt | EBI | MGI Sequence Detail 86 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007432 high affinity immunoglobulin epsilon receptor subunit gamma
    • PDB
    • InterPro Domains
      IPR042340 High affinity immunoglobulin epsilon receptor subunit gamma
      IPR003110 Phosphorylated immunoreceptor signalling ITAM
      IPR021663 T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunit
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 2
      cDNA 31
      Primer pair 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11993, MGD-MRK-9726, MGD-MRK-9730, MGI:2138290
    References
    more
    • Summaries
      All 567
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 33
      Phenotypes 484
    • Earliest
      J:8413 Hibbs ML, et al., The murine Fc receptor for immunoglobulin: purification, partial amino acid sequence, and isolation of cDNA clones. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6980-4
    • Latest
      J:391816 Fan AC, et al., Submicrometre sampling of living cells by macrophages. Nature. 2026 Jun;654(8118):495-503

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory