Kcnj9 MGI Mouse Gene Detail - MGI:108007 - potassium inwardly-rectifying channel, subfamily J, member 9

Symbol

Kcnj9
Name

potassium inwardly-rectifying channel, subfamily J, member 9
Synonyms

1700085N21Rik, Girk3, Kir3.3

Feature Type

protein coding gene
IDs

MGI:108007
NCBI Gene: 16524
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:172148075-172156889 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.66 cM
Mapping Data

12 experiments

SNPs within 2kb

155 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108007	protein coding gene	Chr1:172148068-172156889 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016785	protein coding gene	Chr1:178180223-178188884 (-)
A/J	MGP_AJ_G0016764	protein coding gene	Chr1:170886844-170895529 (-)
AKR/J	MGP_AKRJ_G0016730	protein coding gene	Chr1:176049590-176058253 (-)
BALB/cJ	MGP_BALBcJ_G0016725	protein coding gene	Chr1:171433043-171441711 (-)
C3H/HeJ	MGP_C3HHeJ_G0016549	protein coding gene	Chr1:176623894-176632563 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017187	protein coding gene	Chr1:184095195-184104012 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014893	protein coding gene	Chr1:162590071-162598948 (-)
CAST/EiJ	MGP_CASTEiJ_G0016129	protein coding gene	Chr1:175994127-176002899 (-)
CBA/J	MGP_CBAJ_G0016523	protein coding gene	Chr1:190638496-190647157 (-)
DBA/2J	MGP_DBA2J_G0016630	protein coding gene	Chr1:169823716-169832379 (-)
FVB/NJ	MGP_FVBNJ_G0016627	protein coding gene	Chr1:168078942-168087764 (-)
LP/J	MGP_LPJ_G0016701	protein coding gene	Chr1:179270544-179279211 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016654	protein coding gene	Chr1:197885924-197894592 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017223	protein coding gene	Chr1:175919139-175927809 (-)
PWK/PhJ	MGP_PWKPhJ_G0015915	protein coding gene	Chr1:169199982-169208762 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015697	protein coding gene	Chr1:174870894-174879718 (-)
WSB/EiJ	MGP_WSBEiJ_G0016191	protein coding gene	Chr1:176074644-176083314 (-)

Human Ortholog

KCNJ9, potassium inwardly rectifying channel subfamily J member 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KCNJ9, potassium inwardly rectifying channel subfamily J member 9
Synonyms

GIRK3, KIR3.3
Links

HGNC:6270

NCBI Gene ID: 3765

neXtProt AC: NX_Q92806

UniProt: Q92806
Chr Location

1q23.2; chr1:160055001-160090563 (+) GRCh38.p7

Alliance of Genome Resources

Kcnj9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KCNJ9
Protein SuperFamily

GIRK_kir
Gene Tree

Kcnj9

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

3
Targeted

4
Genomic Mutations

2 involving Kcnj9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

Inactivation of this locus does not result in any overt phenotype.

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

819
Tissues

78
cDNA Data

12
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Kcnj9 interacts with 147 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

47
RefSeq

4
UniProt

2
CCDS

CCDS35783.1

Ensembl

ENSMUSG00000038026 (Evidence)
NCBI Gene

16524

			Length	Strain/Species	Flank
genomic	16524	NCBI Gene Model \| MGI Sequence Detail	8815	C57BL/6J	± kb
transcript	NM_001360808	RefSeq \| MGI Sequence Detail	3914	C57BL/6
polypeptide	P48543	UniProt \| EBI \| MGI Sequence Detail	393	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000002004 G protein-activated inward rectifier potassium channel 3

(term hierarchy)
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR041647 Inward rectifier potassium channel, C-terminal

IPR016449 Potassium channel, inwardly rectifying, Kir

IPR003276 Potassium channel, inwardly rectifying, Kir3.3

IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic

IPR040445 Potassium channel, inwardly rectifying, transmembrane domain

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All nucleic 41

Genomic 23

cDNA 13

Primer pair 5

Microarray probesets 9

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MGD-MRK-37041, MGI:1920728

Summaries

All 77

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 29
Earliest

J:29320 Lesage F, et al., Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett. 1994 Oct 10;353(1):37-42
Latest

J:322829 Taylor EL, et al., GIRK3 deletion facilitates kappa opioid signaling in chondrocytes, delays vascularization and promotes bone lengthening in mice. Bone. 2022 Mar 18;159:116391

TSS for Kcnj9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15214	Chr1:172156884-172156893 (-)	0 bp
Tssr15213	Chr1:172156828-172156874 (-)	38 bp
Tssr15212	Chr1:172153815-172153822 (-)	3,070 bp
Tssr15211	Chr1:172153795-172153805 (-)	3,089 bp
Tssr15210	Chr1:172153785-172153792 (-)	3,100 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/24/2023 MGI 6.22