XRCC1 Vertebrate HGNC

Vertebrate Homology

Source

Alliance of Genome Resources

Comparative GO Graph (mouse, human, rat, zebrafish)

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences select all deselect all Go
human	XRCC1	HGNC:12828 (HGNC) 7515 (Entrez Gene) 194360 (OMIM) XRCC1 (Alliance of Genome Resources)	Chr19 q13.31	Chr19:43543311-43580473 (-) GRCh38	acute lymphoblastic leukemia autosomal recessive spinocerebellar ataxia 26 brain glioma central nervous system cancer cervical cancer chronic myeloid leukemia colorectal adenocarcinoma colorectal cancer colorectal carcinoma contact dermatitis coronary artery disease diabetic retinopathy esophageal cancer esophagus squamous cell carcinoma gallbladder cancer gastric cardia adenocarcinoma gastric cardia carcinoma glioblastoma hepatitis A hepatitis B hepatocellular carcinoma high grade glioma hypertension impotence invasive ductal carcinoma laryngeal carcinoma leiomyoma liver cirrhosis lung adenocarcinoma lung cancer lung non-small cell carcinoma malignant mesothelioma meningioma myelodysplastic syndrome nasopharynx carcinoma oral mucosa leukoplakia pancreatic cancer prostate cancer renal cell carcinoma seminoma senile cataract stomach cancer stomach carcinoma thyroid gland papillary carcinoma transitional cell carcinoma type 2 diabetes mellitus urinary bladder cancer	P18887 (UniProt \| EBI) NM_006297 (RefSeq)
mouse	Xrcc1	MGI:99137 (MGI) 22594 (Entrez Gene) Gene Tree Xrcc1 (Alliance of Genome Resources)	Chr7 11.42 cM	Chr7:24246124-24272863 (+) GRCm39		22594 (NCBI Gene Model) Q60596 (UniProt \| EBI) NM_001360169 (RefSeq)
rat	Xrcc1	RGD:619823 (Rat Genome Database) 84495 (Entrez Gene) Xrcc1 (Alliance of Genome Resources)	Chr1 q21			Q9ESZ0 (UniProt \| EBI) NM_053435 (RefSeq)
zebrafish	xrcc1	ZDB-GENE-040822-30 (Zebrafish Model Organism Database) 445480 (Entrez Gene) xrcc1 (Alliance of Genome Resources)	Chr16			NP_001003988 (RefSeq) NM_001003988 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
- human
- mouse
- rat
- zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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