Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes XRCC1
  • Mouse genes Xrcc1
  • Rat genes Xrcc1
  • Zfish genes xrcc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Xrcc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990599	3' overhang single-stranded DNA endodeoxyribonuclease activity	Xrcc1	IMP		Mouse	MGI:MGI:3758502|PMID:14690602
Molecular Function	GO:0160002	ADP-D-ribose modification-dependent protein binding	XRCC1	IDA		Human	PMID:34102106
Molecular Function	GO:0019899	enzyme binding	XRCC1	IPI	UniProtKB:P49916-3	Human	PMID:8532526
Molecular Function	GO:0032356	oxidized DNA binding	XRCC1	IMP		Human	PMID:28002403
Molecular Function	GO:0072572	poly-ADP-D-ribose binding	XRCC1	IDA		Human	PMID:14500814
Molecular Function	GO:0072572	poly-ADP-D-ribose binding	XRCC1	IDA		Human	PMID:34811483
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q7Z2E3	Human	PMID:14755728
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:P09874	Human	PMID:15044383
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q7Z2E3	Human	PMID:15044383
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q7Z2E3	Human	PMID:15380105
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:P06746	Human	PMID:15520167
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q7Z2E3	Human	PMID:15555565
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q7Z2E3	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q8IW19	Human	PMID:17353262
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q8IW19	Human	PMID:17396150
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q9UNA4	Human	PMID:18923427
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:O96017	Human	PMID:18971944
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:P09874	Human	PMID:18971944
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q96T60	Human	PMID:19155274
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q9NUW8	Human	PMID:19851285
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:P27695	Human	PMID:19934257
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:P06766	Human	PMID:20351257
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q96T60	Human	PMID:21637298
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q8IW19	Human	PMID:23178593
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:P09874	Human	PMID:24778456
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q9NUW8	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:P06766	Human	PMID:25456813
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:P61244	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:P06746	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q96T60	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:P06746	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:Q8IW19	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	XRCC1	IPI	UniProtKB:P09874	Human	PMID:34102106
Molecular Function	GO:0005515	protein binding	Xrcc1	IPI	RGD:3363	Rat	PMID:17412650|RGD:2302580
Cellular Component	GO:0000785	chromatin	XRCC1	IDA		Human	PMID:28002403
Cellular Component	GO:0000781	chromosome, telomeric region	Xrcc1	IDA		Mouse	MGI:MGI:3758502|PMID:14690602
Cellular Component	GO:0070522	ERCC4-ERCC1 complex	Xrcc1	IDA		Mouse	MGI:MGI:3758502|PMID:14690602
Cellular Component	GO:0005730	nucleolus	XRCC1	IDA		Human	PMID:28002403
Cellular Component	GO:0005654	nucleoplasm	XRCC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Xrcc1	IDA		Rat	PMID:17412650|RGD:2302580
Cellular Component	GO:0090734	site of DNA damage	XRCC1	IDA		Human	PMID:14500814
Cellular Component	GO:0090734	site of DNA damage	XRCC1	IDA		Human	PMID:34102106
Cellular Component	GO:0090734	site of DNA damage	XRCC1	IDA		Human	PMID:34811483
Biological Process	GO:0006284	base-excision repair	XRCC1	IDA		Human	PMID:34102106
Biological Process	GO:0006284	base-excision repair	XRCC1	IDA		Human	PMID:34811483
Biological Process	GO:0006284	base-excision repair	Xrcc1	IDA		Rat	PMID:17412650|RGD:2302580
Biological Process	GO:0021587	cerebellum morphogenesis	Xrcc1	IMP		Mouse	MGI:MGI:5902647|PMID:28002403
Biological Process	GO:0006974	DNA damage response	Xrcc1	IEP		Rat	PMID:11056294|RGD:727220
Biological Process	GO:0006281	DNA repair	Xrcc1	IMP	MGI:MGI:3836442	Mouse	PMID:19633665
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	Xrcc1	IMP		Mouse	MGI:MGI:3758502|PMID:14690602
Biological Process	GO:0021766	hippocampus development	Xrcc1	IMP	MGI:MGI:3836442	Mouse	PMID:19633665
Biological Process	GO:1905765	negative regulation of protection from non-homologous end joining at telomere	Xrcc1	IMP		Mouse	MGI:MGI:3758502|PMID:14690602
Biological Process	GO:0010836	negative regulation of protein ADP-ribosylation	XRCC1	IMP		Human	PMID:28002403
Biological Process	GO:0010836	negative regulation of protein ADP-ribosylation	XRCC1	IDA		Human	PMID:34102106
Biological Process	GO:0010836	negative regulation of protein ADP-ribosylation	XRCC1	IDA		Human	PMID:34811483
Biological Process	GO:0010836	negative regulation of protein ADP-ribosylation	Xrcc1	IMP		Mouse	MGI:MGI:5902647|PMID:28002403
Biological Process	GO:1904877	positive regulation of DNA ligase activity	XRCC1	IMP		Human	PMID:28002403
Biological Process	GO:1903518	positive regulation of single strand break repair	XRCC1	IGI	UniProtKB:P09874	Human	PMID:28002403
Biological Process	GO:1903518	positive regulation of single strand break repair	XRCC1	IMP		Human	PMID:28002403
Biological Process	GO:1903518	positive regulation of single strand break repair	Xrcc1	IGI	UniProtKB:P11103	Mouse	MGI:MGI:5902647|PMID:28002403
Biological Process	GO:1990414	replication-born double-strand break repair via sister chromatid exchange	XRCC1	IMP		Human	PMID:28002403
Biological Process	GO:0033194	response to hydroperoxide	XRCC1	IDA		Human	PMID:28002403
Biological Process	GO:0001666	response to hypoxia	Xrcc1	IEP		Rat	PMID:9763211|RGD:2302855
Biological Process	GO:0010033	response to organic substance	Xrcc1	IEP		Rat	PMID:15256147|RGD:2302853
Biological Process	GO:0009410	response to xenobiotic stimulus	Xrcc1	IEP		Rat	PMID:11754170|RGD:2302854
Biological Process	GO:0061819	telomeric DNA-containing double minutes formation	Xrcc1	IMP		Mouse	MGI:MGI:3758502|PMID:14690602
Biological Process	GO:0050882	voluntary musculoskeletal movement	XRCC1	IMP		Human	PMID:28002403
Biological Process	GO:0050882	voluntary musculoskeletal movement	Xrcc1	IGI	UniProtKB:P11103	Mouse	MGI:MGI:5902647|PMID:28002403
Biological Process	GO:0050882	voluntary musculoskeletal movement	Xrcc1	IMP		Mouse	MGI:MGI:5902647|PMID:28002403

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern