POLG Vertebrate HGNC

Vertebrate Homology

Source

Alliance of Genome Resources

Comparative GO Graph (mouse, human, rat, zebrafish)

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences select all deselect all Go
human	POLG	HGNC:9179 (HGNC) 5428 (Entrez Gene) 174763 (OMIM) POLG (Alliance of Genome Resources)	Chr15 q26.1	Chr15:89305198-89334861 (-) GRCh38	Alpers-Huttenlocher syndrome autosomal dominant progressive external ophthalmoplegia 1 autosomal recessive progressive external ophthalmoplegia 1 cardiomyopathy cerebellar ataxia chronic progressive external ophthalmoplegia epilepsy hepatocellular carcinoma mitochondrial DNA depletion syndrome 4b mitochondrial encephalomyopathy multiple sclerosis Parkinson's disease premature menopause primary ovarian insufficiency sensory ataxic neuropathy, dysarthria, and ophthalmoparesis	P54098 (UniProt \| EBI) NM_002693 (RefSeq)
mouse	Polg	MGI:1196389 (MGI) 18975 (Entrez Gene) Gene Tree Polg (Alliance of Genome Resources)	Chr7 45.04 cM	Chr7:79095979-79116110 (-) GRCm39	bipolar disorder mood disorder myelodysplastic syndrome	ENSMUSG00000039176 (Ensembl Gene Model) ENSMUSP00000073551 (Ensembl) ENSMUST00000073889 (Ensembl)
rat	Polg	RGD:620057 (Rat Genome Database) 85472 (Entrez Gene) Polg (Alliance of Genome Resources)	Chr1 q31			Q9QYV8 (UniProt \| EBI) NM_053528 (RefSeq)
zebrafish	polg	ZDB-GENE-060303-1 (Zebrafish Model Organism Database) 100150924 (Entrez Gene) polg (Alliance of Genome Resources)	Chr25			XP_001921130 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
- human
- mouse
- rat
- zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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