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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Nr4a1

Graphs for Molecular Function, Cellular Component, Biological Process generated Mon Apr 26 17:39:58 2021.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nr4a1
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003677DNA bindingNr4a1IDAMouseMGI:MGI:4412441|PMID:18292087
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificNr4a1IDAMouseMGI:MGI:87364|PMID:9155013
Molecular FunctionGO:0001228DNA-binding transcription activator activity, RNA polymerase II-specificNr4a1IDARatPMID:10523643|RGD:10054079
Molecular FunctionGO:0035259glucocorticoid receptor bindingNr4a1IPIUniProtKB:P04150RatPMID:15591535|RGD:10047331
Molecular FunctionGO:0042802identical protein bindingNr4a1IPIMouseMGI:MGI:3797314|PMID:18388149
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:P04637HumanPMID:17139261
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:P03120HumanPMID:18305892
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:P10415HumanPMID:18835031
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:Q9WMX2:PRO_0000037545HumanPMID:18985028
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:Q99873HumanPMID:19095693
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:O60888HumanPMID:20195357
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:P04350HumanPMID:20195357
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:P43243HumanPMID:20195357
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:P50552HumanPMID:20195357
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:Q9P2G1HumanPMID:20195357
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:P32189HumanPMID:21988832
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:P40763HumanPMID:21988832
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:P03120HumanPMID:22761572
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:Q9Y4D7HumanPMID:24139859
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:P55273HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:P60370HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:Q17RB8HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:Q96JS3HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingNR4A1IPIUniProtKB:P55273HumanPMID:31515488
Molecular FunctionGO:0005515protein bindingNr4a1IPIUniProtKB:Q04207MouseMGI:MGI:5927454|PMID:25822914
Molecular FunctionGO:0005515protein bindingNr4a1IPIUniProtKB:O75798MouseMGI:MGI:84485|PMID:8961274
Molecular FunctionGO:0005515protein bindingNr4a1IPIPR:P13405MouseMGI:MGI:3579756|PMID:15701640
Molecular FunctionGO:0005515protein bindingNr4a1IPIPR:P70365MouseMGI:MGI:3047463|PMID:15155786
Molecular FunctionGO:0005515protein bindingNr4a1IPIPR:Q61066MouseMGI:MGI:3047463|PMID:15155786
Molecular FunctionGO:0005515protein bindingNr4a1IPIUniProtKB:Q62318|UniProtKB:Q7TPV4|UniProtKB:Q8VHR5|UniProtKB:Q9DBD5|UniProtKB:Q9R190MouseMGI:MGI:5644023|PMID:19321449
Molecular FunctionGO:0005515protein bindingNr4a1IPIUniProtKB:Q62318RatPMID:19321449|RGD:10047236
Molecular FunctionGO:0046982protein heterodimerization activityNr4a1IDARatPMID:10523643|RGD:10054079
Molecular FunctionGO:0043565sequence-specific DNA bindingNr4a1IDAMouseMGI:MGI:3797314|PMID:18388149
Molecular FunctionGO:0043565sequence-specific DNA bindingNr4a1IDAMouseMGI:MGI:84485|PMID:8961274
Molecular FunctionGO:1990837sequence-specific double-stranded DNA bindingNR4A1IDAHumanPMID:28473536
Molecular FunctionGO:0008134transcription factor bindingNr4a1IPIUniProtKB:Q06219RatPMID:10523643|RGD:10054079
Cellular ComponentGO:0005829cytosolNR4A1IDAHumanGO_REF:0000052
Cellular ComponentGO:0031965nuclear membraneNR4A1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005654nucleoplasmNR4A1IDAHumanGO_REF:0000052
Cellular ComponentGO:0005634nucleusNr4a1IDAMouseMGI:MGI:4412441|PMID:18292087
Cellular ComponentGO:0005634nucleusNr4a1IDAMouseMGI:MGI:3721333|PMID:17434920
Cellular ComponentGO:0005634nucleusNr4a1IDAMouseMGI:MGI:2667579|PMID:12815108
Cellular ComponentGO:0005634nucleusNr4a1IDARatPMID:15942958|RGD:1598733
Cellular ComponentGO:0005667transcription regulator complexNr4a1IDAMouseMGI:MGI:87364|PMID:9155013
Biological ProcessGO:0006915apoptotic processNr4a1IMPMGI:MGI:2182325MouseMGI:MGI:3721333|PMID:17434920
Biological ProcessGO:0002042cell migration involved in sprouting angiogenesisNR4A1IDAHumanPMID:18059339
Biological ProcessGO:0071376cellular response to corticotropin-releasing hormone stimulusNr4a1IDAMouseMGI:MGI:5645213|PMID:10523643
Biological ProcessGO:0044344cellular response to fibroblast growth factor stimulusNR4A1IMPHumanPMID:18059339
Biological ProcessGO:0071310cellular response to organic substanceNr4a1IDAMouseMGI:MGI:4947150|PMID:21357543
Biological ProcessGO:0035924cellular response to vascular endothelial growth factor stimulusNR4A1IMPHumanPMID:18059339
Biological ProcessGO:0035767endothelial cell chemotaxisNR4A1IMPHumanPMID:18059339
Biological ProcessGO:0045444fat cell differentiationNr4a1IDAMouseMGI:MGI:5645207|PMID:18945812
Biological ProcessGO:0045786negative regulation of cell cycleNr4a1IDAMouseMGI:MGI:5645207|PMID:18945812
Biological ProcessGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic processNr4a1IDAMouseMGI:MGI:2667579|PMID:12815108
Biological ProcessGO:0043065positive regulation of apoptotic processNr4a1IDAMouseMGI:MGI:2683352|PMID:14657025
Biological ProcessGO:0001938positive regulation of endothelial cell proliferationNR4A1IMPHumanPMID:18059339
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IINR4A1IDAHumanPMID:22427340
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IINr4a1IDAMouseMGI:MGI:84485|PMID:8961274
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IINr4a1IGIMGI:MGI:1276523|MGI:MGI:1352460MouseMGI:MGI:3047463|PMID:15155786
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IINr4a1IMPMGI:MGI:2182325MouseMGI:MGI:6114559|PMID:28775000
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IINr4a1IGIMGI:MGI:97874|MGI:MGI:1339708MouseMGI:MGI:3579756|PMID:15701640
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IINr4a1IDAMouseMGI:MGI:3047463|PMID:15155786
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IINr4a1IDAMouseMGI:MGI:87364|PMID:9155013
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IINr4a1IDARatPMID:10523643|RGD:10054079
Biological ProcessGO:0045944positive regulation of transcription by RNA polymerase IINr4a1IDARatPMID:19321449|RGD:10047236
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedNr4a1IDAMouseMGI:MGI:2683352|PMID:14657025
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedNr4a1IDAMouseMGI:MGI:84485|PMID:8961274
Biological ProcessGO:0061469regulation of type B pancreatic cell proliferationNr4a1IMPRatPMID:24706823|RGD:10054075
Biological ProcessGO:0051602response to electrical stimulusNr4a1IEPRatPMID:9630512|RGD:14700867
Biological ProcessGO:0032496response to lipopolysaccharideNr4a1IEPRatPMID:8821744|RGD:14700868
Biological ProcessGO:0035914skeletal muscle cell differentiationNr4a1IMPMouseMGI:MGI:5300631|PMID:22147266

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory