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Nr4a1 Gene Detail
Summary
  • Symbol
    Nr4a1
  • Name
    nuclear receptor subfamily 4, group A, member 1
  • Synonyms
    Gfrp, GFRP1, Hbr1, Hbr-1, Hmr, N10, NGFI-B, NP10, Nur77, TIS1, TR3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352454
    NCBI Gene: 15370
  • Gene Overview
    MyGene.info: NR4A1
Location & Maps
more
  • Sequence Map
    Chr15:101266846-101274792 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7947 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.64 cM, cytoband F
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NR4A1, nuclear receptor subfamily 4 group A member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NR4A1, nuclear receptor subfamily 4 group A member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3
  • Links
    NCBI Gene ID: 3164
    neXtProt AC: NX_P22736

  • Chr Location
    12q13; chr12:52022832-52059507 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotypes from multigenic genotypes
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Radiation induced
    2
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    3 involving Nr4a1
  • Incidental Mutations
Mice homozygous for a targeted null mutation are viable, fertile, and display a normal HPA axis function, as well as normal thymic and peripheral T cell deletion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023034 Ensembl Gene Model | MGI Sequence Detail 7947 C57BL/6J ±  kb
transcript ENSMUST00000023779 Ensembl | MGI Sequence Detail 2474 Not Applicable  
polypeptide ENSMUSP00000023779 Ensembl | MGI Sequence Detail 601 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    148 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011408 nuclear receptor subfamily 4 group A member 1
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003070 Orphan nuclear receptor
    IPR003071 Orphan nuclear receptor, HMR type
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 68
    Genomic 1
    cDNA 65
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10057, MGD-MRK-10641, MGD-MRK-10642, MGI:95699, MGI:96029
References
more
  • Summaries
    All 140
    Developmental Gene Expression 17
    Diseases 2
    Gene Ontology 20
    Phenotypes 68
  • Earliest
    J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
  • Latest
    J:233012 Hamers AA, et al., Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance. BMC Genomics. 2016;17:162

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory