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Nr4a1
Gene Detail
Symbol

Name
ID
Nr4a1
nuclear receptor subfamily 4, group A, member 1
MGI:1352454
Synonyms
Gfrp, GFRP1, Hbr1, Hbr-1, Hmr, N10, NGFI-B, NP10, Nur77, TIS1, TR3
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.64 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:101266846-101274792 bp, + strand
From Ensembl annotation of GRCm38

  7947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1612  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NR4A1
Protein SuperFamily: nerve growth factor IB-like nuclear receptor
Gene Tree: Nr4a1

Human
homologs
NR4A1, nuclear receptor subfamily 4, group A, member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3164
neXtProt AC: NX_P22736

Human Synonyms: GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3

Human Chr (Location): 12q13; chr12:52022832-52059507 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(1) Gene trapped(11) Radiation induced(1) Targeted(4)
Genomic Mutations involving Nr4a1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable, fertile, and display a normal HPA axis function, as well as normal thymic and peripheral T cell deletion.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Nr4a1 interacts with 111 markers (Mir34a, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process apoptotic process, cell migration involved in sprouting angiogenesis, ...
Component cytoplasm, nuclear membrane, ...
Function DNA binding, glucocorticoid receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (165)    Tissues (76)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 146
Northern blot 18
RT-PCR 1
cDNA source data(65)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase nr4a1 ; ZFIN nr4a1    NEW 
Molecular
reagents
All nucleic(68) Genomic(1) cDNA(65) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000023034 (Evidence)
Entrez Gene 15370 (Evidence)
UniGene 119
DFCI TC1574935
DoTS DT.492328
NIA Mouse Gene Index U016686
Consensus CDS Project CCDS27848.1
International Mouse Phenotyping Consortium Status Nr4a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023034 Ensembl Gene Model | MGI Sequence Detail 7947 C57BL/6J ±  kb
transcript ENSMUST00000023779 Ensembl | MGI Sequence Detail 2474 Not Applicable 
polypeptide ENSMUSP00000023779 Ensembl | MGI Sequence Detail 601 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(10) UniProt(2)
Polymorphisms
SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001723 Nuclear hormone receptor
InterPro IPR000536 Nuclear hormone receptor, ligand-binding domain
InterPro IPR003070 Orphan nuclear receptor
InterPro IPR003071 Orphan nuclear receptor, HMR type
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011408 nuclear receptor subfamily 4 group A member 1
References
(Earliest) J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
(Latest) J:218022 Niu G, et al., Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin beta4. FASEB J. 2015 Jan;29(1):131-40
All references(131)
Other
accession IDs
MGD-MRK-10057, MGD-MRK-10641, MGD-MRK-10642, MGI:95699, MGI:96029

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory