Nr4a1
Gene Detail

Symbol Name ID

Nr4a1 nuclear receptor subfamily 4, group A, member 1 MGI:1352454

Synonyms

Gfrp, GFRP1, Hbr1, Hbr-1, Hmr, N10, NGFI-B, NP10, Nur77, TIS1, TR3

Feature Type

protein coding gene

Genetic Map

Chromosome 15

56.64 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:101266846-101274792 bp, + strand From Ensembl annotation of GRCm38   7947 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1612  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: nerve growth factor IB-like nuclear receptor
Gene Tree: Nr4a1

Human homologs

Human Homolog		NR4A1, nuclear receptor subfamily 4, group A, member 1
NCBI Gene ID		3164
neXtProt AC		NX_P22736
Human Synonyms		GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3
Human Chr (Location)		12q13; chr12:52416616-52453291 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(14) : Targeted(3) Gene trapped(11)
 

Mice homozygous for a targeted null mutation are viable, fertile, and display a normal HPA axis function, as well as normal thymic and peripheral T cell deletion.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	apoptotic process, cell migration involved in sprouting angiogenesis, ...
Component	nucleus, transcription factor complex
Function	DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (164)    Tissues (73)    Images (37)
Theiler Stages: 16, 18, 21, 23, 26, 28

Assay Type	Results
RNA in situ	145
Northern blot	18
RT-PCR	1

cDNA source data(65)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(68) Genomic(1) cDNA(65) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000023034 (Evidence)
Entrez Gene	15370 (Evidence)
UniGene	119
DFCI	TC1574935
DoTS	DT.492328
NIA Mouse Gene Index	U016686
Consensus CDS Project	CCDS27848.1
International Mouse Knockout Project Status	Nr4a1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000023034	Ensembl Gene Model | MGI Sequence Detail	7947	C57BL/6J
transcript	ENSMUST00000023779	Ensembl | MGI Sequence Detail	2474	Not Applicable
polypeptide	ENSMUSP00000023779	Ensembl | MGI Sequence Detail	601	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(98 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR003070	Orphan nuclear receptor
InterPro	IPR003071	Orphan nuclear receptor, HMR type
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000011408	nuclear receptor subfamily 4 group A member 1

References

(Earliest) J:9454 Tippetts MT, et al., Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol. 1988 Oct;8(10):4570-2
(Latest) J:192704 Hanna RN, et al., NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circ Res. 2012 Feb 3;110(3):416-27
All references(109)

Other accession IDs

MGD-MRK-10057, MGD-MRK-10641, MGD-MRK-10642, MGI:95699, MGI:96029