Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Itga3

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ITGA3
- Mouse genes Itga3
- Rat genes Itga3
- Zfish genes itga3a,itga3b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Itga3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005518	collagen binding	Itga3	IDA		Rat	PMID:1835909\|RGD:2325829
Molecular Function	GO:0001968	fibronectin binding	Itga3	IDA		Rat	PMID:1835909\|RGD:2325829
Molecular Function	GO:0005178	integrin binding	Itga3	IPI	RGD:2927	Rat	PMID:2223092\|RGD:2325828
Molecular Function	GO:0043236	laminin binding	Itga3	IDA		Rat	PMID:1835909\|RGD:2325829
Molecular Function	GO:0043236	laminin binding	Itga3	IMP		Rat	PMID:2223092\|RGD:2325828
Molecular Function	GO:0002020	protease binding	ITGA3	IPI	UniProtKB:Q12884	Human	PMID:10455171
Molecular Function	GO:0005515	protein binding	ITGA3	IPI	UniProtKB:P48509	Human	PMID:10811835
Molecular Function	GO:0005515	protein binding	ITGA3	IPI	UniProtKB:P48509	Human	PMID:14557253
Molecular Function	GO:0005515	protein binding	ITGA3	IPI	UniProtKB:P48509	Human	PMID:14676841
Molecular Function	GO:0005515	protein binding	ITGA3	IPI	UniProtKB:P27797	Human	PMID:1911778
Molecular Function	GO:0005515	protein binding	ITGA3	IPI	UniProtKB:P48509	Human	PMID:24220332
Molecular Function	GO:0005515	protein binding	ITGA3	IPI	UniProtKB:O14817	Human	PMID:9360996
Molecular Function	GO:0005515	protein binding	Itga3	IPI	UniProtKB:O35566\|UniProtKB:P28828	Mouse	MGI:MGI:6294221\|PMID:14691142
Molecular Function	GO:0005515	protein binding	Itga3	IPI	UniProtKB:P48509	Mouse	PMID:17716972
Molecular Function	GO:0005515	protein binding	Itga3	IPI	PR:P09055	Mouse	PMID:12904471
Molecular Function	GO:0005515	protein binding	Itga3	IPI	RGD:2116	Rat	PMID:17016859\|RGD:10401134
Molecular Function	GO:0019904	protein domain specific binding	Itga3	IMP		Rat	PMID:2223092\|RGD:2325828
Molecular Function	GO:0046982	protein heterodimerization activity	ITGA3	IDA		Human	PMID:10455171
Molecular Function	GO:0044877	protein-containing complex binding	Itga3	IPI	RGD:733764	Rat	PMID:2223092\|RGD:2325828
Cellular Component	GO:0016323	basolateral plasma membrane	Itga3	IDA		Mouse	PMID:7534781
Cellular Component	GO:0016323	basolateral plasma membrane	Itga3	IDA		Mouse	PMID:11891657
Cellular Component	GO:0071944	cell periphery	ITGA3	IDA		Human	PMID:24220332
Cellular Component	GO:0009986	cell surface	ITGA3	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	ITGA3	IDA		Human	PMID:19933311
Cellular Component	GO:0009986	cell surface	ITGA3	IDA		Human	PMID:20563599
Cellular Component	GO:0009986	cell surface	ITGA3	IDA		Human	PMID:21310825
Cellular Component	GO:0009986	cell surface	ITGA3	IDA		Human	PMID:24220332
Cellular Component	GO:0009986	cell surface	ITGA3	IDA		Human	PMID:25063885
Cellular Component	GO:0009986	cell surface	Itga3	IDA		Rat	PMID:2223092\|RGD:2325828
Cellular Component	GO:0060076	excitatory synapse	Itga3	IDA		Mouse	PMID:23595732
Cellular Component	GO:0009897	external side of plasma membrane	Itga3	IDA		Mouse	PMID:9553049
Cellular Component	GO:0070062	extracellular exosome	ITGA3	HDA		Human	PMID:19056867
Cellular Component	GO:0031527	filopodium membrane	ITGA3	IDA		Human	PMID:10455171
Cellular Component	GO:0005925	focal adhesion	ITGA3	HDA		Human	PMID:21423176
Cellular Component	GO:0098978	glutamatergic synapse	Itga3	IMP		Mouse	PMID:29091766
Cellular Component	GO:0098978	glutamatergic synapse	Itga3	IDA		Mouse	PMID:29091766
Cellular Component	GO:0098978	glutamatergic synapse	Itga3	IDA		Rat	PMID:27518800\|RGD:155230752
Cellular Component	GO:0030426	growth cone	Itga3	IDA		Rat	PMID:16987960\|RGD:2325857
Cellular Component	GO:1990812	growth cone filopodium	Itga3	IDA		Rat	PMID:7544141\|RGD:13593531
Cellular Component	GO:0034667	integrin alpha3-beta1 complex	ITGA3	IMP		Human	PMID:24220332
Cellular Component	GO:0034667	integrin alpha3-beta1 complex	ITGA3	IDA		Human	PMID:25063885
Cellular Component	GO:0034667	integrin alpha3-beta1 complex	Itga3	IDA		Rat	PMID:1835909\|RGD:2325829
Cellular Component	GO:0031594	neuromuscular junction	Itga3	IMP		Mouse	PMID:28386022
Cellular Component	GO:0031594	neuromuscular junction	Itga3	IDA		Mouse	PMID:28386022
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Itga3	IDA		Rat	PMID:20470260\|RGD:2325256
Cellular Component	GO:0005886	plasma membrane	ITGA3	IDA		Human	PMID:21310825
Cellular Component	GO:0005886	plasma membrane	Itga3	IDA		Mouse	PMID:14566019
Cellular Component	GO:0005886	plasma membrane	Itga3	IDA		Rat	PMID:20470260\|RGD:2325256
Cellular Component	GO:0045211	postsynaptic membrane	Itga3	IDA		Rat	PMID:27518800\|RGD:155230752
Cellular Component	GO:0048787	presynaptic active zone membrane	Itga3	IDA		Mouse	PMID:28386022
Cellular Component	GO:0043235	receptor complex	ITGA3	IDA		Human	PMID:23382219
Cellular Component	GO:0045202	synapse	Itga3	IDA		Mouse	PMID:12904471
Cellular Component	GO:0097060	synaptic membrane	Itga3	IDA		Mouse	PMID:23595732
Biological Process	GO:0007610	behavior	Itga3	IMP	MGI:MGI:1857792	Mouse	PMID:23595732
Biological Process	GO:0007155	cell adhesion	Itga3	IMP		Rat	PMID:2223092\|RGD:2325828
Biological Process	GO:0097062	dendritic spine maintenance	Itga3	IGI	MGI:MGI:87860	Mouse	PMID:23595732
Biological Process	GO:0097062	dendritic spine maintenance	Itga3	IMP	MGI:MGI:1857792	Mouse	PMID:23595732
Biological Process	GO:0035640	exploration behavior	Itga3	IGI	MGI:MGI:87860	Mouse	PMID:23595732
Biological Process	GO:0033333	fin development	itga3b	IMP	ZFIN:ZDB-GENO-100420-11	Zfish	PMID:9007245
Biological Process	GO:0033334	fin morphogenesis	itga3b	IMP	ZFIN:ZDB-GENO-100528-10	Zfish	PMID:20419147
Biological Process	GO:0007507	heart development	Itga3	IEP		Rat	PMID:1835909\|RGD:2325829
Biological Process	GO:0030324	lung development	ITGA3	IMP		Human	PMID:24621570
Biological Process	GO:0060135	maternal process involved in female pregnancy	Itga3	IEP		Rat	PMID:20353731\|RGD:2325260
Biological Process	GO:0007613	memory	Itga3	IMP	MGI:MGI:1857792	Mouse	PMID:12904471
Biological Process	GO:0048333	mesodermal cell differentiation	ITGA3	IEP		Human	PMID:23154389
Biological Process	GO:0031345	negative regulation of cell projection organization	Itga3	IMP		Rat	PMID:20039268\|RGD:2325266
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	Itga3	IGI	MGI:MGI:1929494	Mouse	PMID:23595732
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	Itga3	IGI	MGI:MGI:87860	Mouse	PMID:23595732
Biological Process	GO:0072006	nephron development	ITGA3	IMP		Human	PMID:24621570
Biological Process	GO:0001764	neuron migration	Itga3	IMP		Mouse	PMID:15091337
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	Itga3	IMP		Rat	PMID:2223092\|RGD:2325828
Biological Process	GO:0010634	positive regulation of epithelial cell migration	Itga3	IMP		Rat	PMID:20470260\|RGD:2325256
Biological Process	GO:0010628	positive regulation of gene expression	Itga3	IDA		Rat	PMID:16938651\|RGD:2325858
Biological Process	GO:0010976	positive regulation of neuron projection development	Itga3	IMP		Rat	PMID:2223092\|RGD:2325828
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ITGA3	IDA		Human	PMID:10455171
Biological Process	GO:0099173	postsynapse organization	Itga3	IDA		Mouse	PMID:29091766
Biological Process	GO:0099173	postsynapse organization	Itga3	IMP		Mouse	PMID:29091766
Biological Process	GO:0030510	regulation of BMP signaling pathway	ITGA3	IMP		Human	PMID:24621570
Biological Process	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	ITGA3	IMP		Human	PMID:24621570
Biological Process	GO:0030111	regulation of Wnt signaling pathway	ITGA3	IMP		Human	PMID:24621570
Biological Process	GO:0097205	renal filtration	ITGA3	IMP		Human	PMID:24621570
Biological Process	GO:0034698	response to gonadotropin	Itga3	IEP		Rat	PMID:20189708\|RGD:2325263
Biological Process	GO:0009410	response to xenobiotic stimulus	Itga3	IEP		Rat	PMID:20525748\|RGD:2325818
Biological Process	GO:0007266	Rho protein signal transduction	Itga3	IGI	MGI:MGI:87860	Mouse	PMID:23595732
Biological Process	GO:0007266	Rho protein signal transduction	Itga3	IGI	MGI:MGI:1929494	Mouse	PMID:23595732
Biological Process	GO:0043588	skin development	ITGA3	IMP		Human	PMID:24621570
Biological Process	GO:0099560	synaptic membrane adhesion	Itga3	IMP		Mouse	PMID:28386022
Biological Process	GO:0099560	synaptic membrane adhesion	Itga3	IDA		Mouse	PMID:28386022

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.