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Itga3 Gene Detail
Summary
  • Symbol
    Itga3
  • Name
    integrin alpha 3
  • Synonyms
    alpha3-integrin, VLA-3 alpha 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96602
    NCBI Gene: 16400
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:94935300-94967627 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    902 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96602
 protein coding gene Chr11:94935300-94967637 (-)
129S1/SvImJ ENSMUSG00200049557
 protein coding gene Chr11:92178574-92210928 (-)
A/J ENSMUSG00195049825
 protein coding gene Chr11:91900104-91932364 (-)
AKR/J ENSMUSG00220049621
 protein coding gene Chr11:92159059-92191311 (-)
BALB/cJ ENSMUSG00180046607
 protein coding gene Chr11:92146941-92179256 (-)
C3H/HeJ ENSMUSG00175051277
 protein coding gene Chr11:92159576-92191827 (-)
C57BL/6NJ ENSMUSG00215053025
 protein coding gene Chr11:91751626-91783973 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017000
 protein coding gene Chr11:90790560-90822386 (-)
CAST/EiJ ENSTCUG00005016870
 protein coding gene Chr11:91608718-91641059 (-)
CBA/J ENSMUSG00210052756
 protein coding gene Chr11:91862978-91895227 (-)
DBA/2J ENSMUSG00185050621
 protein coding gene Chr11:92200327-92232675 (-)
FVB/NJ ENSMUSG00205031861
 protein coding gene Chr11:92065589-92097935 (-)
JF1/MsJ ENSUMUG00000021065
 protein coding gene Chr11:92515067-92547343 (-)
LP/J ENSMUSG00230044739
 protein coding gene Chr11:93261818-93294165 (-)
NOD/ShiLtJ ENSMUSG00190049063
 protein coding gene Chr11:92240720-92273036 (-)
NZO/HlLtJ ENSMUSG00225049566
 protein coding gene Chr11:95308400-95340701 (-)
PWK/PhJ ENSLUMG00010028126
 protein coding gene Chr11:92062887-92095231 (-)
SPRET/EiJ ENSMSPG00010027047
 protein coding gene Chr11:92545742-92577567 (-)
WSB/EiJ ENSIUOG00005043581
 protein coding gene Chr11:92008100-92040235 (-)



Homology
more
  • Human Ortholog
    ITGA3, integrin subunit alpha 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA3, integrin subunit alpha 3
  • Synonyms
    CD49C, FRP-2, GAP-B3, GAPB3, ILNEB, JEB7, MSK18, VCA-2, VL3A, VLA3a
  • Links
    NCBI Gene ID: 3675
    UniProt: P26006

  • Chr Location
    17q21.33; chr17:50055968-50090485 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ITGA3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 5 alleles in 8 genetic backgrounds
    35 phenotypes from multigenic genotypes
    4 images
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit defects of the kidney and submandibular gland, decreased bronchial branching of the lungs, skin blisters at the dermal-epidermal junction, abnormal layering of the cerebral cortex and perinatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    101
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1272
  • Tissues
    412
  • cDNA Data
    78
  • Literature Summary
    71
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001507 Ensembl Gene Model | MGI Sequence Detail 32328 C57BL/6J ±  kb
    transcript ENSMUST00000120375 Ensembl | MGI Sequence Detail 4697 Not Applicable  
    polypeptide ENSMUSP00000113556 Ensembl | MGI Sequence Detail 1068 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000009128 integrin alpha-3
      (term hierarchy)
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048286 Integrin alpha, third immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
    • GlyGen
      Q62470 13 sites, 16 N-linked glycans (11 sites)
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 1
      cDNA 79
      Primer pair 6
      Other 2
      Antibodies 7

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11481, MGI:2143964
    References
    more
    • Summaries
      All 205
      Developmental Gene Expression 71
      Gene Ontology 21
      Phenotypes 76
    • Earliest
      J:41315 Tamura RN, et al., Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10183-7
    • Latest
      J:373565 Shao G, et al., Podocyte YAP ablation decreases podocyte adhesion and exacerbates FSGS progression through alpha3beta1 integrin. J Pathol. 2025 Jan;265(1):84-98
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory