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Itga3
Gene Detail
 Symbol
Name
ID
Itga3
integrin alpha 3
MGI:96602
Synonyms alpha3-integrin, VLA-3 alpha 3
Feature Type protein coding gene
Genetic Map
Chromosome 11
59.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:95044474-95076801 bp, - strand
From VEGA annotation of GRCm38

  32328 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21129  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: integrin alpha, VLA protein type
Gene Tree: Itga3

Human
homologs
Human Homolog ITGA3, integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
NCBI Gene ID 3675
neXtProt AC  NX_P26006
Human Synonyms  CD49C, GAPB3, GAP-B3, ILNEB, MSK18, VCA-2, VL3A, VLA3a
Human Chr (Location)  17q21.33; chr17:50055976-50090485 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ITGA3
Alleles
and
phenotypes
All alleles(27) : Targeted(6) Gene trapped(21)
 
Homozygotes for a targeted null mutation exhibit defects of the kidney and submandibular gland, decreased bronchial branching of the lungs, skin blisters at the dermal-epidermal junction, abnormal layering of the cerebral cortex and perinatal lethality.
 
Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell adhesion, integrin-mediated signaling pathway, ...
Component basolateral plasma membrane, cell surface, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (55 records)
Data Summary: Results (570)    Tissues (373)    Images (82)
Theiler Stages: 4, 11, 13, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 28
RNA in situ 488
RT-PCR 54
cDNA source data(76)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(83) Genomic(1) cDNA(77) Primer pair(5)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000001616 (Evidence)
Ensembl Gene ModelENSMUSG00000001507 (Evidence)
Entrez Gene16400 (Evidence)
UniGene57035
DFCITC1578585, TC1600557
DoTSDT.489005, DT.526833, DT.91307059, DT.94304912, DT.97371060
NIA Mouse Gene IndexU033297
Consensus CDS ProjectCCDS25271.1
International Mouse Knockout Project StatusItga3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001616 VEGA Gene Model | MGI Sequence Detail 32328 C57BL/6J ±  kb
transcript OTTMUST00000003161 VEGA | MGI Sequence Detail 4697 Not Applicable 
polypeptide OTTMUSP00000001531 VEGA | MGI Sequence Detail 1068 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(6) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(262 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013517 FG-GAP repeat
InterPro IPR013649 Integrin alpha-2
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR000413 Integrin alpha chain
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Protein Ontology PR:000009128 integrin alpha-3
References (Earliest) J:41315 Tamura RN, et al., Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10183-7
(Latest) J:205736 Sachs N, et al., Reduced susceptibility to two-stage skin carcinogenesis in mice with epidermis-specific deletion of CD151. J Invest Dermatol. 2014 Jan;134(1):221-8
All references(140)
Other
accession IDs
MGD-MRK-11481, MGI:2143964

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory