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Itga3 Gene Detail
Summary
  • Symbol
    Itga3
  • Name
    integrin alpha 3
  • Synonyms
    alpha3-integrin, VLA-3 alpha 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:96602
    NCBI Gene: 16400
  • Gene Overview
    MyGene.info: ITGA3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:95044474-95076801 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32328 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.01 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ITGA3, integrin subunit alpha 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ITGA3, integrin subunit alpha 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD49C, FRP-2, GAPB3, GAP-B3, ILNEB, MSK18, VCA-2, VL3A, VLA3a
  • Links
    NCBI Gene ID: 3675
    neXtProt AC: NX_P26006
    UniProt: P26006

  • Chr Location
    17q21.33; chr17:50055968-50090485 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 4 alleles in 7 genetic backgrounds
    35 phenotypes from multigenic genotypes
    4 images
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit defects of the kidney and submandibular gland, decreased bronchial branching of the lungs, skin blisters at the dermal-epidermal junction, abnormal layering of the cerebral cortex and perinatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001616 VEGA Gene Model | MGI Sequence Detail 32328 C57BL/6J ±  kb
    transcript OTTMUST00000003161 VEGA | MGI Sequence Detail 4697 Not Applicable  
    polypeptide OTTMUSP00000001531 VEGA | MGI Sequence Detail 1068 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      261 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 84
      Genomic 1
      cDNA 77
      Primer pair 5
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
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    MGD-MRK-11481, MGI:2143964
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 59
      Gene Ontology 14
      Phenotypes 55
    • Earliest
      J:41315 Tamura RN, et al., Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10183-7
    • Latest
      J:253651 Hu JK, et al., An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice. Cell Stem Cell. 2017 Jul 6;21(1):91-106.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory