Phenotypes Associated with This Genotype

Genotype
MGI:8246631

• Allelic Composition: Acaa1a^em1Syki/Acaa1a⁺; Kras^tm4Tyj/Kras⁺; Trp53^tm2Tyj/Trp53⁺; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased tumor-free survival time ( J:371968 )

• mice exhibit a median survival of 19 weeks, that is 3 weeks longer than that of KPC mice alone (Kras^tm4Tyj/Kras⁺ Trp53^tm2Tyj/Trp53⁺ Tg(Pdx1-cre)6Tuv/0 mice that are wild-type for Acaa1a)

• at 22 weeks, the survival rate is 34% versus 0% observed in KPC mice alone, indicating an improvement in the overall survival of KPC mice

neoplasm

decreased tumor cell proliferation ( J:371968 )

• percentage of Ki-67 positive cells in pancreatic cancer tissue is significantly lower than that in KPC mice alone

decreased tumor growth/size ( J:371968 )

• immunohistochemical staining for Ki-67 in pancreatic cancer tissue indicates that the Ki-67-positive area is reduced by 96% relative to KPC mice alone, consistent with suppressed tumor growth

homeostasis/metabolism

enhanced autophagy ( J:371968 )

• average H-score for LC3-II in pancreatic cancer tissue is 2.3 times higher than that in KPC mice alone, suggesting increased autophagy

cellular

enhanced autophagy ( J:371968 )

• average H-score for LC3-II in pancreatic cancer tissue is 2.3 times higher than that in KPC mice alone, suggesting increased autophagy