Phenotypes Associated with This Genotype

Genotype
MGI:6256732

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Pten^tm2Mak/Pten⁺; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased cholangiocarcinoma incidence ( J:254370 )

• some lesions are diagnosed as intrahepatic cholangiocarcinoma by the appearance of adenocarcinoma showing tubular and/or papillary structures with a fibrous stroma; these tumor cells show loss of Pten expression

increased liver tumor incidence ( J:254370 )

• mice develop liver tumors at 6 months of age, showing obvious symptoms after 7 months with abdominal distension due to multiple tumors at later stages

• mice develop liver tumors with both hepatocyte and cholangiocyte differentiation

increased hepatocellular carcinoma incidence ( J:254370 )

• majority of large nodules are hepatocellular dysplasia, a precursor lesion of hepatocellular carcinoma

liver/biliary system

increased cholangiocarcinoma incidence ( J:254370 )

• some lesions are diagnosed as intrahepatic cholangiocarcinoma by the appearance of adenocarcinoma showing tubular and/or papillary structures with a fibrous stroma; these tumor cells show loss of Pten expression

increased liver tumor incidence ( J:254370 )

• mice develop liver tumors at 6 months of age, showing obvious symptoms after 7 months with abdominal distension due to multiple tumors at later stages

• mice develop liver tumors with both hepatocyte and cholangiocyte differentiation

increased hepatocellular carcinoma incidence ( J:254370 )

• majority of large nodules are hepatocellular dysplasia, a precursor lesion of hepatocellular carcinoma

endocrine/exocrine glands

increased cholangiocarcinoma incidence ( J:254370 )

• some lesions are diagnosed as intrahepatic cholangiocarcinoma by the appearance of adenocarcinoma showing tubular and/or papillary structures with a fibrous stroma; these tumor cells show loss of Pten expression