Phenotypes Associated with This Genotype

Genotype
MGI:6192377

• Allelic Composition: Kdm6a^tm1Cdcn/Y; Tg(CAG-cre/Esr1*)5Amc/0; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C57BL/6J * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:263565 )

• tamoxifen-treated mice have a median survival of 3.8 months

neoplasm

increased chronic myelocytic leukemia incidence ( J:263565 )

• tamoxifen treated mice develop chronic myelomonocytic leukemia-like disease with a shorter latency than single Kdm6a mutants

hematopoietic system

enlarged spleen ( J:263565 )

• splenomegaly develops 3 months after tamoxifen injection

anemia ( J:263565 )

• in tamoxifen treated mice

increased granulocyte monocyte progenitor cell number ( J:263565 )

• increase in number of granulocyte-macrophage progenitor (GMP) cells in the bone marrow of tamoxifen treated mice

decreased erythrocyte cell number ( J:263565 )

• decrease in number of red blood cells in tamoxifen treated mice which is greater than in either single mutant

increased neutrophil cell number ( J:263565 )

• expansion of neutrophils in the spleen, bone marrow, liver and peripheral blood of tamoxifen treated mice

thrombocytopenia ( J:263565 )

• decrease in number of platelets in tamoxifen treated mice which is greater than in either single mutant

increased monocyte cell number ( J:263565 )

• increase in the number of monocytes in tamoxifen treated mice, which is much greater than in either single mutant

increased myeloid cell number ( J:263565 )

• expansion of myeloid cells in the spleen, bone marrow, liver, and peripheral blood of tamoxifen treated mice

increased hematopoietic stem cell number ( J:263565 )

• an increase in the number and proportion of hematopoietic stem cells (HSCs) in the bone marrow of tamoxifen treated mice, however the number of bone marrow cells is normal

immune system

enlarged spleen ( J:263565 )

• splenomegaly develops 3 months after tamoxifen injection

increased neutrophil cell number ( J:263565 )

• expansion of neutrophils in the spleen, bone marrow, liver and peripheral blood of tamoxifen treated mice

increased monocyte cell number ( J:263565 )

• increase in the number of monocytes in tamoxifen treated mice, which is much greater than in either single mutant

growth/size/body

enlarged spleen ( J:263565 )

• splenomegaly develops 3 months after tamoxifen injection