Phenotypes Associated with This Genotype

Genotype
MGI:5527245

• Allelic Composition: Col1a1^{tm1(CAG-Mir22)Ppp}/Col1a1^{tm1(CAG-Mir22)Ppp}; Tg(Mx1-cre)1Cgn/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal hematopoietic system morphology/development ( J:199366 )

• after cre induction using pIpC

• hematological abnormalities in all mice after 16 months

increased T cell derived lymphoma incidence ( J:199366 )

• after cre induction by pIpC

• in 11 months

enlarged spleen ( J:199366 )

• splenomegaly

• myeloid infiltration

abnormal erythropoiesis ( J:199366 )

• defective erythroid development

anemia ( J:199366 )

increased myeloid dendritic cell number ( J:199366 )

• increased number of mature cells

decreased leukocyte cell number ( J:199366 )

• low white blood cell count

• dysplastic peripheral myeloid cells

increased hematopoietic stem cell number ( J:199366 )

neoplasm

increased T cell derived lymphoma incidence ( J:199366 )

• after cre induction by pIpC

• in 11 months

increased leukemia incidence ( J:199366 )

• after cre induction by pIpC

• 13% succumb to myeloid leukemia by 11 months

• 70% die within two years

immune system

increased T cell derived lymphoma incidence ( J:199366 )

• after cre induction by pIpC

• in 11 months

enlarged spleen ( J:199366 )

• splenomegaly

• myeloid infiltration

increased myeloid dendritic cell number ( J:199366 )

• increased number of mature cells

decreased leukocyte cell number ( J:199366 )

• low white blood cell count

• dysplastic peripheral myeloid cells

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:199366 )

• after cre induction by pIpC

• in 11 months

growth/size/body

enlarged spleen ( J:199366 )

• splenomegaly

• myeloid infiltration