Col1a1^{tm1(CAG-Mir22)Ppp}
Targeted Allele Detail

Summary

• Symbol: Col1a1^{tm1(CAG-Mir22)Ppp}
• Name: collagen, type I, alpha 1; targeted mutation 1, Pier Paolo Pandolfi
• MGI ID: MGI:5527244
• Synonyms: miR-22^F
• Gene: Col1a1 Location: Chr11:94827050-94843868 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Col1a1^{tm1(CAG-Mir22)Ppp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199366
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Col1a1^{tm1(CAG-Mir22)Ppp} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mir22 (MGI:2676896)

• Mutation details: A cassette containing an FRT site followed by CAG, then a floxed stop element, Mir22 sequence, a second FRT site and, finally, a hygromycin resistance selection cassette was inserted in the 3' UTR. (J:199366)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col1a1 Mutation: 160 strains or lines available

References

• Original: J:199366 Song SJ, et al., The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation. Cell Stem Cell. 2013 Jul 3;13(1):87-101
• All: 3 reference(s)