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Phenotypes Associated with This Genotype
Genotype
MGI:5432226
Allelic
Composition
Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0
Genetic
Background
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (27 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (41 available)
Tg(CYP19A1-cre)1Jri mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mutants die within 2-3 months of age due to tumor burden

neoplasm
• mutants exhibit precancerous lesions in the ovaries by 3 weeks of age
• mutants develop large granulosa cell tumors by 6-8 weeks of age

endocrine/exocrine glands
• granulosa cell proliferation is increased and apoptosis is decreased in the ovaries at 5-6 weeks of age
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
• mutants exhibit precancerous lesions in the ovaries by 3 weeks of age
• mutants develop large granulosa cell tumors by 6-8 weeks of age

reproductive system
• granulosa cell proliferation is increased and apoptosis is decreased in the ovaries at 5-6 weeks of age
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked
• mutants exhibit precancerous lesions in the ovaries by 3 weeks of age
• mutants develop large granulosa cell tumors by 6-8 weeks of age

homeostasis/metabolism

cellular
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked

Mouse Models of Human Disease
OMIM ID Ref(s)
Ovarian Cancer 167000 J:186144


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory