Mouse Genome Informatics
cn
    Ctnnb1tm1Mmt/Ctnnb1+
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0

involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• all mutants die within 2-3 months of age due to tumor burden

tumorigenesis
• mutants exhibit precancerous lesions in the ovaries by 3 weeks of age (J:186144)
• mutants develop large granulosa cell tumors by 6-8 weeks of age (J:186144)

endocrine/exocrine glands
• granulosa cell proliferation is increased and apoptosis is decreased in the ovaries at 5-6 weeks of age (J:186144)
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked (J:186144)

reproductive system
• granulosa cell proliferation is increased and apoptosis is decreased in the ovaries at 5-6 weeks of age (J:186144)
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked (J:186144)

homeostasis/metabolism

cellular
• marker analysis indicates that at 6 weeks of age granulosa cell differentiation is blocked (J:186144)

Mouse Models of Human Disease
OMIM IDRef(s)
Ovarian Cancer 167000 J:186144