Analysis Tools
mortality/aging
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• a further loss of mice is seen between E12.5 and E14.5
• however, some mice survive to adulthood
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• the expected number of mice are found at E10.5 but fewer than expected are found at E12.5
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hematopoietic system
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• fetal livers contain very few erythrocytes but numbers of other hematopoietic lineage cells are similar to controls at E12.5
• severe impairment in the differentiation of proerythroblasts into erythroblasts in the fetal liver at E14.5
• total numbers of BFU-E and CFU-E are dramatically lower in fetal livers compared to controls
• however, embryonic erythropoiesis is similar to controls
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• severe in embryos
• however, surviving adults have normal steady-state hematocrit
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• dramatic reduction in the number of erythrocytes in the fetal liver at E14.5
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• increase in the number of LSK cells in the fetal liver at E14.5
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• cultured erythroid cells are more sensitive to apoptotic stimulation compared to control cells
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liver/biliary system
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• enlarged fetal liver cells and reduced total liver cellularity at E12.5 and E14.5
• livers contain very few hematopoietic cells unlike in controls at E12.5
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pale liver
(
J:171578
)
|
• at E12.5
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cardiovascular system
| N |
• despite recombination in endothelial cells, no obvious vascular defects are detected
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integument
