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Phenotypes Associated with This Genotype
Genotype
MGI:3837856
Allelic
Composition
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Col1a1tm2(CAG-EGFR*)Char/Col1a1tm2(CAG-EGFR*)Char
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (56 available)
Col1a1tm2(CAG-EGFR*)Char mutation (1 available); any Col1a1 mutation (143 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• following intracranial injection of an adenoviral cre, mice develop glioblastoma multiforme with no mice surviving tumor-free beyond 10 weeks unlike similarly treated Col1a1tm2(CAG-EGFR*)Char homozygotes that do not develop tumors

mortality/aging
• no mice surviving tumor-free beyond 10 weeks following intracranial injection of an adenoviral cre unlike similarly treated Col1a1tm2(CAG-EGFR*)Char homozygotes that do not develop tumors

neoplasm
• following intracranial injection of an adenoviral cre, mice develop glioblastoma multiforme with no mice surviving tumor-free beyond 10 weeks unlike similarly treated Col1a1tm2(CAG-EGFR*)Char homozygotes that do not develop tumors

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
high grade glioma DOID:3070 OMIM:PS137800
J:146494


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory