Phenotypes Associated with This Genotype

Genotype
MGI:3783529

• Allelic Composition: Rb1^tm3Tyj/Rb1^tm3Tyj; Trp53^tm1Tyj/Trp53^tm1Tyj; Tg(Nes-cre)1Atp/0
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:91406 )

• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit an average lifespan of 92+/-15 days and are moribund with pituitary tumors when euthanized

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:91406 )

• mice with mosaic cre expression with maternal inheritance of Tg(Nes-cre)1Mrt exhibit pituitary tumors

vision/eye

increased retina apoptosis ( J:91406 )

• retinal apoptosis levels are higher than in wild-type and Rb1^tm3Tyj/Rb1^tm3Tyj Tg(Nes-cre)1Mrt mice

abnormal eye morphology ( J:91406 )

• dysplasia in both eyes

abnormal retina morphology ( J:91406 )

• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit focal retinal dysplasia

decreased retina photoreceptor cell number ( J:91406 )

thin retina outer nuclear layer ( J:91406 )

• in mice with mosaic cre expression when Tg(Nes-cre)1Mrt is maternally inherited

neoplasm

increased pituitary gland tumor incidence ( J:91406 )

• mice with mosaic cre expression with maternal inheritance of Tg(Nes-cre)1Mrt exhibit pituitary tumors

nervous system

increased pituitary gland tumor incidence ( J:91406 )

• mice with mosaic cre expression with maternal inheritance of Tg(Nes-cre)1Mrt exhibit pituitary tumors

decreased retina photoreceptor cell number ( J:91406 )

cellular

increased retina apoptosis ( J:91406 )

• retinal apoptosis levels are higher than in wild-type and Rb1^tm3Tyj/Rb1^tm3Tyj Tg(Nes-cre)1Mrt mice