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Phenotypes Associated with This Genotype
Genotype
MGI:3710322
Allelic
Composition
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Trp53tm1Brn/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2ctm1Bbd mutation (1 available); any Cdkn2c mutation (6 available)
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Brn mutation (17 available); any Trp53 mutation (155 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 4/4 of mice receiving 4 Gy radiation at P5 develop cerebellar tumors by 5 months of age

neoplasm
• 4/4 of mice receiving 4 Gy radiation at P5 develop cerebellar tumors by 5 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
medulloblastoma DOID:0050902 OMIM:155255
J:102702


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory