Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GFAP-cre)#Mzhu mutation
(0 available)
Triotm1Mzhu mutation
(0 available);
any
Trio mutation
(132 available)
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behavior/neurological
N |
• mice exhibit normal behavior
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nervous system
N |
• mice exhibit normal cerebellum development
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation
(4 available)
Triotm1Mzhu mutation
(0 available);
any
Trio mutation
(132 available)
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Growth retardation, ataxia, small brain size, and reduced olfactory bulb size in Triotm1Mzhu/Triotm1Mzhu Tg(Nes-cre)1Kln/0 mice
mortality/aging
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• 90% of mice die within 1 day of birth
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• remaining mice die between P5 and P22
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nervous system
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• cerebellar granule neurons exhibit impaired neurite growth compared with wild-type cells
• neurite outgrowth is unresponsive to Netrin-1 and Semaphorin 6A induction unlike wild-type cells
• however, neurite ougrowth is normally induced by glutamate and nerve growth factor
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• most granules remain outside of the Purkinje cell layer and are randomly at the external granular layer and molecular layer unlike in wild-type mice
• cultured granule cells exhibit decreased migration with random orientations along their abnormal processes compared with similarly treated wild-type mice
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• parallel fibers are thick and non-compact compared to in wild-type mice
• mice lack horizontal beams of parallel fibers in the inner external granule cell layer compared with wild-type mice
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• the rostral migratory stream is enlarged compared to in wild-type mice
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• indistinguishable with the internal granule cell layer
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• between P8 and P21 glial fibers become progressively sparse unlike in wild-type mice
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• at P0.5, the inner granular layer lacks granule cells compared to in wild-type mice
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• granule cells in the external granule layer exhibit disorganized cell bodies with abnormal organization of parallel fibers compared with wild-type mice
• granules exhibit short and highly branched processes, irregular growth cone with highly branched terminals, and strong filipodia in the axon shaft and the tips of leading process compared with wild-type cells
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• some sub-lobules fail to form unlike in wild-type mice
• however, all lobules do form
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behavior/neurological
growth/size/body
cellular
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• cerebellar granule neurons exhibit impaired neurite growth compared with wild-type cells
• neurite outgrowth is unresponsive to Netrin-1 and Semaphorin 6A induction unlike wild-type cells
• however, neurite ougrowth is normally induced by glutamate and nerve growth factor
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• most granules remain outside of the Purkinje cell layer and are randomly at the external granular layer and molecular layer unlike in wild-type mice
• cultured granule cells exhibit decreased migration with random orientations along their abnormal processes compared with similarly treated wild-type mice
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