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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smotm2.1Amc
targeted mutation 2.1, Andrew P McMahon
MGI:4834775
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Smotm2Amc/Smotm2.1Amc
Tg(Wnt1-cre)11Rth/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J MGI:4843924
cn2
Smotm2Amc/Smotm2.1Amc
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd * 129X1/SvJ MGI:4843927
cn3
Smotm2Amc/Smotm2.1Amc
Tg(Mpz-cre)94Imeg/0
involves: 129X1/SvJ MGI:4843926
cn4
Smotm2Amc/Smotm2.1Amc
Tg(Tek-cre)12Flv/0
involves: 129X1/SvJ * C57BL/6 MGI:4843921
cn5
Smotm2Amc/Smotm2.1Amc
Tg(Tnnt2-cre)5Blh/0
involves: 129X1/SvJ * C57BL/6 * DBA/2 MGI:4843922
cn6
Smotm2Amc/Smotm2.1Amc
Tg(Wnt1-cre)11Rth/0
involves: 129X1/SvJ * C57BL/6J * CBA/J MGI:4843923


Genotype
MGI:4843924
cn1
Allelic
Composition
Smotm2Amc/Smotm2.1Amc
Tg(Wnt1-cre)11Rth/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (343 available)
Smotm2.1Amc mutation (0 available); any Smo mutation (19 available)
Smotm2Amc mutation (1 available); any Smo mutation (19 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

cardiovascular system
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

nervous system
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

cellular
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice




Genotype
MGI:4843927
cn2
Allelic
Composition
Smotm2Amc/Smotm2.1Amc
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background
involves: 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (7 available)
Smotm2.1Amc mutation (0 available); any Smo mutation (19 available)
Smotm2Amc mutation (1 available); any Smo mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E10.5 and E18.5, mice exhibit abnormal arch-artery patterning compared to in wild-type mice
• at E10.5, mice exhibit short outflow tract compared with wild-type mice
• mice exhibit cell death in the anterior heart field unlike in wild-type mice

embryo
• mice exhibit cell death in neural crest cells unlike in wild-type mice
• mice exhibit abnormal neural crest cells localization and septation defects compared with wild-type mice

cellular
• mice exhibit cell death in neural crest cells unlike in wild-type mice
• mice exhibit abnormal neural crest cells localization and septation defects compared with wild-type mice




Genotype
MGI:4843926
cn3
Allelic
Composition
Smotm2Amc/Smotm2.1Amc
Tg(Mpz-cre)94Imeg/0
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smotm2.1Amc mutation (0 available); any Smo mutation (19 available)
Smotm2Amc mutation (1 available); any Smo mutation (19 available)
Tg(Mpz-cre)94Imeg mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• authors state that mice exhibit identical cardiac defects as observed in Smotm2Amc/Smotm2.1Amc Tg(Wnt1-cre)11Rth mice




Genotype
MGI:4843921
cn4
Allelic
Composition
Smotm2Amc/Smotm2.1Amc
Tg(Tek-cre)12Flv/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smotm2.1Amc mutation (0 available); any Smo mutation (19 available)
Smotm2Amc mutation (1 available); any Smo mutation (19 available)
Tg(Tek-cre)12Flv mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit normal outflow tract development




Genotype
MGI:4843922
cn5
Allelic
Composition
Smotm2Amc/Smotm2.1Amc
Tg(Tnnt2-cre)5Blh/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smotm2.1Amc mutation (0 available); any Smo mutation (19 available)
Smotm2Amc mutation (1 available); any Smo mutation (19 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit normal outflow tract development




Genotype
MGI:4843923
cn6
Allelic
Composition
Smotm2Amc/Smotm2.1Amc
Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smotm2.1Amc mutation (0 available); any Smo mutation (19 available)
Smotm2Amc mutation (1 available); any Smo mutation (19 available)
Tg(Wnt1-cre)11Rth mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E10.5 and E18.5, mice exhibit arch-artery defects compared with wild-type mice
• in 4 of 23 mice
• mice exhibit partial septation of the outflow tract unlike wild-type mice
• in 17 of 23 mice
• 2 of 23 mice exhibit complete separation of a transposed aorta and hypoplastic pulmonary artery unlike in wild-type mice

embryo
• mice exhibit cell death in neural crest cells unlike in wild-type mice

cellular
• mice exhibit cell death in neural crest cells unlike in wild-type mice





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory