Mouse Genome Informatics
cn1
    Smotm2Amc/Smotm2.1Amc
Tg(Wnt1-cre)11Rth/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+

involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
embryogenesis
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice

nervous system
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice


Mouse Genome Informatics
cn2
    Smotm2Amc/Smotm2.1Amc
Nkx2-5tm1(cre)Rjs/Nkx2-5+

involves: 129S7/SvEvBrd * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• at E10.5 and E18.5, mice exhibit abnormal arch-artery patterning compared to in wild-type mice
• at E10.5, mice exhibit short outflow tract compared with wild-type mice
• mice exhibit cell death in the anterior heart field unlike in wild-type mice

embryogenesis
• mice exhibit cell death in neural crest cells unlike in wild-type mice
• mice exhibit abnormal neural crest cells localization and septation defects compared with wild-type mice

cellular
• mice exhibit cell death in neural crest cells unlike in wild-type mice
• mice exhibit abnormal neural crest cells localization and septation defects compared with wild-type mice


Mouse Genome Informatics
cn3
    Smotm2Amc/Smotm2.1Amc
Tg(Mpz-cre)94Imeg/0

involves: 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• authors state that mice exhibit identical cardiac defects as observed in Smotm2Amc/Smotm2.1Amc Tg(Wnt1-cre)11Rth mice


Mouse Genome Informatics
cn4
    Smotm2Amc/Smotm2.1Amc
Tg(Tek-cre)12Flv/0

involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
N
• mice exhibit normal outflow tract development (J:135134)


Mouse Genome Informatics
cn5
    Smotm2Amc/Smotm2.1Amc
Tg(Tnnt2-cre)5Blh/0

involves: 129X1/SvJ * C57BL/6 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
N
• mice exhibit normal outflow tract development (J:135134)


Mouse Genome Informatics
cn6
    Smotm2Amc/Smotm2.1Amc
Tg(Wnt1-cre)11Rth/0

involves: 129X1/SvJ * C57BL/6J * CBA/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• at E10.5 and E18.5, mice exhibit arch-artery defects compared with wild-type mice
• in 4 of 23 mice
• mice exhibit partial septation of the outflow tract unlike wild-type mice
• in 17 of 23 mice
• 2 of 23 mice exhibit complete separation of a transposed aorta and hypoplastic pulmonary artery unlike in wild-type mice

embryogenesis
• mice exhibit cell death in neural crest cells unlike in wild-type mice

cellular
• mice exhibit cell death in neural crest cells unlike in wild-type mice