Analysis Tools
integument
| N |
• mice do not exhibit skin inflammation unlike Tg(CD2-Stat6*V625A*T626A)78Mhk mice
• mice exhibit normal recovery from retinoic acid treatment
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Allele Symbol Allele Name Allele ID |
Tg(CD2-Stat6*V625A*T626A)78Mhk transgene insertion 78, Mark H Kaplan MGI:3845883 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice do not exhibit skin inflammation unlike Tg(CD2-Stat6*V625A*T626A)78Mhk mice
• mice exhibit normal recovery from retinoic acid treatment
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• keratitis is seen in 35% of mice by 20 weeks of age
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• infiltration of a mixed inflammatory cell infiltrate in the dermis of both the upper and lower eyelids
• a lymphocyte-predominant infiltrate containing variable numbers of eosinophils, macrophages, and neutrophils are seen in the substantia propria of the eyelids
• treatment of eyelids with clobetasol reverses blepharitis
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• inflammatory infiltrate is seen in the Meibomian glands
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• corneal disease (neovascular pannus formation) is seen
• cornea exhibits keratinization of the epithelial layer, increased stromal inflammatory cells, neovascularization and corneal edema
• proteinous exudates with cellular infiltrates are seen along with erosion of the Descemente's membrane
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• eyelid erythema evident as early as 7 weeks of age
• Th2 cytokine expression is increased in eyelids, indicating allergic inflammation
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• excoriations and madarosis evident as early as 7 weeks of age
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• keratitis is seen in 35% of mice by 20 weeks of age
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• infiltration of a mixed inflammatory cell infiltrate in the dermis of both the upper and lower eyelids
• a lymphocyte-predominant infiltrate containing variable numbers of eosinophils, macrophages, and neutrophils are seen in the substantia propria of the eyelids
• treatment of eyelids with clobetasol reverses blepharitis
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• inflammatory infiltrate is seen in the Meibomian glands
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• peripheral neovascularization of the cornea, which extends centrally
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• inflammatory infiltrate is seen in the Meibomian glands
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• inflammatory infiltrate is seen in the Meibomian glands
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• excoriations and madarosis evident as early as 7 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• resulting in alopecia on the face, back, and other areas
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• 10 days after retinoic acid treatment, mice exhibit a 4-fold elevation in transepithelial water loss unlike similarly treated wild-type mice
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• mice develop skin inflammation that is similar to atopic dermatitis unlike wild-type mice
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• 10 days after retinoic acid treatment, mice exhibit a 4-fold elevation in transepithelial water loss unlike similarly treated wild-type mice
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• mice develop skin inflammation that is similar to atopic dermatitis unlike wild-type mice
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• eosinophils and lymphocytes
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| atopic dermatitis | DOID:3310 |
OMIM:603165 OMIM:PS603165 |
J:160119 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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