Mouse Genome Informatics
cn1
    Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm2Tyj/Rbl2tm2Tyj
Trp53tm1Brn/Trp53tm1Brn

involves: 129P2/OlaHsd * 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• adeno-cre-treated mice begin to die at 17 weeks and by 6 months all mice are moribund

tumorigenesis
• 3 and 6 months, adeno-cre-treated mice exhibit primary lung tumors with metastasis to the liver unlike wild-type mice
• at 3 and 6 month, adeno-cre-treated mice exhibit more tumors than in similarly treated Rb1tm3Tyj Trp53tm1Brn homozygotes
• adeno-cre-treated mice exhibit few lung adenocarcinomas, adenocarcinomas with neuroendocrine features, large-cell neuroendocrine carcinoma, and large-cell carcinomas while most tumors resemble neuroendocrine small-cell lung tumors
• most tumors in adeno-cre-treated mice resemble those found in human neuroendocrine small cell lung cancer patients

Mouse Models of Human Disease
OMIM IDRef(s)
Small Cell Cancer of the Lung 182280 J:160148


Mouse Genome Informatics
cn2
    Krastm4Tyj/Kras+
Rbl2tm2Tyj/Rbl2tm2Tyj

involves: 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• median life span of cre adenovirus-treated mice is 25 weeks

tumorigenesis
• tumors from cre adenovirus-treated mice exhibit lower cell proliferation rates compared to in tumors from Krastm4Tyj heterozygotes and Krastm4Tyj/Kras+ Rb1tm3Tyj/Rb1tm3Tyj mice
• cre adenovirus-treated mice develop larger tumors than in cre adenovirus-treated Krastm4Tyj heterozygotes and Krastm4Tyj/Kras+ Rb1tm3Tyj/Rb1tm3Tyj mice
• mice treated with adenovirus cre develop lung lesions in 4 to 6 months
• cre adenovirus-treated mice develop lung adenocarcinomas, papillary adenomas and bronchiolar hyperplasia and dysplasia
• in cre adenovirus-treated mice

respiratory system
• in cre-adenovirus-treated mice
• cre adenovirus-treated mice develop bronchiolar hyperplasia and dysplasia unlike wild-type mice