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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rbl2tm2Tyj
targeted mutation 2, Tyler Jacks
MGI:3706581
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Rb1tm2Brn/Rb1tm2Brn
Rbl1tm1Tyj/Rbl1tm1Tyj
Rbl2tm2Tyj/Rbl2tm2Tyj
involves: 129 * 129S2/SvPas * 129S4/SvJae MGI:5789748
cn2
Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm2Tyj/Rbl2tm2Tyj
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S4/SvJae MGI:4459447
cn3
Krastm4Tyj/Kras+
Rbl2tm2Tyj/Rbl2tm2Tyj
involves: 129S4/SvJae MGI:3842378


Genotype
MGI:5789748
cn1
Allelic
Composition
Rb1tm2Brn/Rb1tm2Brn
Rbl1tm1Tyj/Rbl1tm1Tyj
Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic
Background
involves: 129 * 129S2/SvPas * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (4 available); any Rb1 mutation (61 available)
Rbl1tm1Tyj mutation (1 available); any Rbl1 mutation (37 available)
Rbl2tm2Tyj mutation (1 available); any Rbl2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice injected with an adenovirus expressing cre-recombinase (AdCre) into the bladder lumen all develop bladder lesions that resemble high-grade non-muscle-invasive carcinoma
• bladder tumors display high proliferation and invade the basal lamina
• metastases are not seen for up to 1 year after AdCre infection

renal/urinary system
• hematuria is sometimes seen in mice injected with AdCre into the bladder lumen with bladder lesions
• mice injected with an adenovirus expressing cre-recombinase (AdCre) into the bladder lumen all develop bladder lesions that resemble high-grade non-muscle-invasive carcinoma
• bladder tumors display high proliferation and invade the basal lamina
• metastases are not seen for up to 1 year after AdCre infection

homeostasis/metabolism
• hematuria is sometimes seen in mice injected with AdCre into the bladder lumen with bladder lesions

Mouse Models of Human Disease
OMIM ID Ref(s)
Bladder Cancer 109800 J:217195




Genotype
MGI:4459447
cn2
Allelic
Composition
Rb1tm3Tyj/Rb1tm3Tyj
Rbl2tm2Tyj/Rbl2tm2Tyj
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm3Tyj mutation (1 available); any Rb1 mutation (61 available)
Rbl2tm2Tyj mutation (1 available); any Rbl2 mutation (22 available)
Trp53tm1Brn mutation (6 available); any Trp53 mutation (146 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• 3 and 6 months, adeno-cre-treated mice exhibit primary lung tumors with metastasis to the liver unlike wild-type mice
• at 3 and 6 month, adeno-cre-treated mice exhibit more tumors than in similarly treated Rb1tm3Tyj Trp53tm1Brn homozygotes
• adeno-cre-treated mice exhibit few lung adenocarcinomas, adenocarcinomas with neuroendocrine features, large-cell neuroendocrine carcinoma, and large-cell carcinomas while most tumors resemble neuroendocrine small-cell lung tumors
• most tumors in adeno-cre-treated mice resemble those found in human neuroendocrine small cell lung cancer patients

mortality/aging
• adeno-cre-treated mice begin to die at 17 weeks and by 6 months all mice are moribund

neoplasm
• 3 and 6 months, adeno-cre-treated mice exhibit primary lung tumors with metastasis to the liver unlike wild-type mice
• at 3 and 6 month, adeno-cre-treated mice exhibit more tumors than in similarly treated Rb1tm3Tyj Trp53tm1Brn homozygotes
• adeno-cre-treated mice exhibit few lung adenocarcinomas, adenocarcinomas with neuroendocrine features, large-cell neuroendocrine carcinoma, and large-cell carcinomas while most tumors resemble neuroendocrine small-cell lung tumors
• most tumors in adeno-cre-treated mice resemble those found in human neuroendocrine small cell lung cancer patients

Mouse Models of Human Disease
OMIM ID Ref(s)
Small Cell Cancer of the Lung 182280 J:160148




Genotype
MGI:3842378
cn3
Allelic
Composition
Krastm4Tyj/Kras+
Rbl2tm2Tyj/Rbl2tm2Tyj
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (4 available); any Kras mutation (32 available)
Rbl2tm2Tyj mutation (1 available); any Rbl2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median life span of cre adenovirus-treated mice is 25 weeks

neoplasm
• tumors from cre adenovirus-treated mice exhibit lower cell proliferation rates compared to in tumors from Krastm4Tyj heterozygotes and Krastm4Tyj/Kras+ Rb1tm3Tyj/Rb1tm3Tyj mice
• cre adenovirus-treated mice develop larger tumors than in cre adenovirus-treated Krastm4Tyj heterozygotes and Krastm4Tyj/Kras+ Rb1tm3Tyj/Rb1tm3Tyj mice
• mice treated with adenovirus cre develop lung lesions in 4 to 6 months
• cre adenovirus-treated mice develop lung adenocarcinomas, papillary adenomas and bronchiolar hyperplasia and dysplasia
• in cre adenovirus-treated mice

respiratory system
• mice treated with adenovirus cre develop lung lesions in 4 to 6 months
• cre adenovirus-treated mice develop lung adenocarcinomas, papillary adenomas and bronchiolar hyperplasia and dysplasia
• in cre adenovirus-treated mice
• in cre-adenovirus-treated mice
• cre adenovirus-treated mice develop bronchiolar hyperplasia and dysplasia unlike wild-type mice





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory