mortality/aging
• 50% of mice die within 7 weeks from birth and none survive over 4 months of age
• treatment with LY294002, an inhibitor of PI3K, twice a week starting at 3 weeks of age prolongs survival of mice
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endocrine/exocrine glands
• mice develop thyroids 200- to 500-fold larger than controls
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• mice rapidly develop thyroid follicular carcinomas
• 30-90% of the thyroid glands are replaced by microfollicular to solid areas, indicating thyroid follicular cancer, including capsular, muscle, and vascular invasion
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homeostasis/metabolism
neoplasm
• mice rapidly develop thyroid follicular carcinomas
• 30-90% of the thyroid glands are replaced by microfollicular to solid areas, indicating thyroid follicular cancer, including capsular, muscle, and vascular invasion
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• all mice surviving at least 12 weeks develop thyroglobulin-positive lung metastases
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