Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2tm1Aksh mutation
(0 available);
any
Sfrp2 mutation
(26 available)
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limbs/digits/tail
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• 3% of homozygotes display hindlimb syndactyly
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation
(0 available);
any
Sfrp1 mutation
(17 available)
Sfrp2tm1Aksh mutation
(0 available);
any
Sfrp2 mutation
(26 available)
Sfrp5tm1Aksh mutation
(0 available);
any
Sfrp5 mutation
(25 available)
Vangl2Lp mutation
(2 available);
any
Vangl2 mutation
(34 available)
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embryo
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• mice exhibit an anterior-posterior elongation defect that is enhanced in the trunk relative to that observed in Sfrp1tm1Aksh/Sfrp1tm1Aksh Sfrp2tm1Aksh/Sfrp2tm1Aksh Sfrp5tm1Aksh/Sfrp5+ mice
• at late head-fold stage, mice exhibit abnormal convergence and extension
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nervous system
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation
(0 available);
any
Sfrp1 mutation
(17 available)
Sfrp2tm1Aksh mutation
(0 available);
any
Sfrp2 mutation
(26 available)
Sfrp5tm1Aksh mutation
(0 available);
any
Sfrp5 mutation
(25 available)
Vangl2Lp mutation
(2 available);
any
Vangl2 mutation
(34 available)
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nervous system
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• 62% of mice exhibit spina bifida
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embryo
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• 62% of mice exhibit spina bifida
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation
(0 available);
any
Sfrp1 mutation
(17 available)
Sfrp2tm1Aksh mutation
(0 available);
any
Sfrp2 mutation
(26 available)
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mortality/aging
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• embryos die around E16.5
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embryo
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• embryos have defective posterior axis extension detectable by increased thickness of the mesoderm layer in the posterior region
(J:106551)
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• entire body axis is shortened
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• results suggest somites 11-23 are fused, and/or reduced in number
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• regular somites smaller than normal are generated in a posterior region near the hindlimb and the forelimb levels
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• at E9.5, there is randomized or incomplete segmentation of somites
(J:106551)
• at E10.5,there is a segmentation defect in the middle of the trunk; there is randomized segmentation after the eleventh somite in the region between the forelimb and the hindlimb
(J:106551)
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homeostasis/metabolism
craniofacial
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• craniofacial abnormalities are visible
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limbs/digits/tail
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• embryos exhibit syndactyly detectable at E14.5, primarily in the anterior region of the right hindlimb. rarely on the left hindlimb
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• mutant embryos display limb outgrowth defects
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skeleton
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• thoracic region is severely shortened, and the number of thoracic vertebrae is reduced from 13 to 5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation
(0 available);
any
Sfrp1 mutation
(17 available)
Sfrp2tm1Aksh mutation
(0 available);
any
Sfrp2 mutation
(26 available)
Sfrp5tm1Aksh mutation
(0 available);
any
Sfrp5 mutation
(25 available)
|
|
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp1tm1Aksh mutation
(0 available);
any
Sfrp1 mutation
(17 available)
Sfrp2tm1Aksh mutation
(0 available);
any
Sfrp2 mutation
(26 available)
Sfrp5tm1Aksh mutation
(0 available);
any
Sfrp5 mutation
(25 available)
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mortality/aging
embryo
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• mice exhibit more severe anterior-posterior axis defects than in Sfrp1tm1Aksh Sfrp2tm1Aksh homozygotes
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• at E8.5, fused small somites are present
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• at E8.5, fused small somites are present
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nervous system
growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Sia mutation
(0 available);
any
Dkk1 mutation
(17 available)
Sfrp1tm1Aksh mutation
(0 available);
any
Sfrp1 mutation
(17 available)
Sfrp2tm1Aksh mutation
(0 available);
any
Sfrp2 mutation
(26 available)
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embryo
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• intersomitic boundaries are absent in the posterior portion
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Sia mutation
(0 available);
any
Dkk1 mutation
(17 available)
Sfrp1tm1Aksh mutation
(0 available);
any
Sfrp1 mutation
(17 available)
Sfrp2tm1Aksh mutation
(0 available);
any
Sfrp2 mutation
(26 available)
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embryo
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• pre-somitic mesoderm is reduced
• however, the notochord and tail bud mesoderm are present
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