About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
H2g7
g7 variant
MGI:3579321
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
H2b/H2g7 NOD.B10SnJ-H2b MGI:3628790
ht2
H2h2/H2g7 NOD.Cg-H2h2 MGI:3628788
ht3
H2h4/H2g7 NOD.Cg-H2h4 MGI:3628787
ht4
H2i5/H2g7 NOD.Cg-H2i5 MGI:3628789
ht5
H2i7/H2g7 NOD.Cg-H2i7 MGI:3628791
ht6
H2k/H2g7 NOD.Cg-H2k MGI:3628792
ht7
H2i7/H2g7 (NOD x NOD.Cg-H2i7)F1 MGI:3628793
cx8
H2g7/H2g7
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
B6.Cg-H2g7 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi MGI:3640480
cx9
H2g7/H2g7
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
B6.NOD-(D17Mit21-D17Mit10) Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs MGI:4868729
cx10
H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687167
cx11
H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687164
cx12
H2g7/H2g7
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687169
cx13
H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD MGI:3687165
cx14
H2b/H2g7
Tg(TcraR28,TcrbR28)KRNDim/0
involves: C57BL/6 * NOD * SJL MGI:3842820
cx15
H2g7/H2g7
Tg(Ins2-Vtcn1)#Xxz/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
involves: C57BL/6 * NOD * SJL MGI:5463746


Genotype
MGI:3628790
ht1
Allelic
Composition
H2b/H2g7
Genetic
Background
NOD.B10SnJ-H2b
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (24 available); any H2 mutation (276 available)
H2g7 mutation (23 available); any H2 mutation (276 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no females develop diabetes spontaneously over 5-7 months




Genotype
MGI:3628788
ht2
Allelic
Composition
H2h2/H2g7
Genetic
Background
NOD.Cg-H2h2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
H2h2 mutation (1 available); any H2 mutation (276 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no females develop diabetes spontaneously over 5-7 months




Genotype
MGI:3628787
ht3
Allelic
Composition
H2h4/H2g7
Genetic
Background
NOD.Cg-H2h4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
H2h4 mutation (19 available); any H2 mutation (276 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no females develop diabetes spontaneously over 5-7 months




Genotype
MGI:3628789
ht4
Allelic
Composition
H2i5/H2g7
Genetic
Background
NOD.Cg-H2i5
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
H2i5 mutation (3 available); any H2 mutation (276 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no females develop diabetes spontaneously over 5-7 months




Genotype
MGI:3628791
ht5
Allelic
Composition
H2i7/H2g7
Genetic
Background
NOD.Cg-H2i7
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
H2i7 mutation (1 available); any H2 mutation (276 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no females develop diabetes spontaneously over 5-7 months




Genotype
MGI:3628792
ht6
Allelic
Composition
H2k/H2g7
Genetic
Background
NOD.Cg-H2k
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
H2k mutation (15 available); any H2 mutation (276 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no females develop diabetes spontaneously over 5-7 months




Genotype
MGI:3628793
ht7
Allelic
Composition
H2i7/H2g7
Genetic
Background
(NOD x NOD.Cg-H2i7)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
H2i7 mutation (1 available); any H2 mutation (276 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• no female mice develop insulitis between 5-7 months of age; a small number of male mice do display mild insulitis

immune system
• no female mice develop insulitis between 5-7 months of age; a small number of male mice do display mild insulitis




Genotype
MGI:3640480
cx8
Allelic
Composition
H2g7/H2g7
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic
Background
B6.Cg-H2g7 Tg(TcraBDC2.5,TcrbBDC2.5)1Doi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• animals show a significant reduction in overall diabetes incidence (14.6% vs ~50% in Tnfsf4-heterozygotes and wild-type) and increase in the age of onset (9.5 weeks vs 6 weeks in controls)
• mice are considered diabetic after a blood glucose measure of >300 mg/dl and 2 positive urine glucose tests




Genotype
MGI:4868729
cx9
Allelic
Composition
H2g7/H2g7
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background
B6.NOD-(D17Mit21-D17Mit10) Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
Tg(TcraAI4)1Dvs mutation (4 available)
Tg(TcrbAI4)1Dvs mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Background Sensitivity: although negative selection of these transgenic thymocytes is stronger on the B6 than NOD background, there is earlier onset and greater penetrance of diabetes in females on the B6 background
• Background Sensitivity: compared with those on the NOD background, on the B6 background these TCR transgenic T cells have greater proliferative response to antigen presentation and display more potent killing of pancreatic islet cells




Genotype
MGI:3687167
cx10
Allelic
Composition
H2g7/H2g7
Ins2tm1Jja/Ins2tm1Jja
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
Ins2tm1Jja mutation (4 available); any Ins2 mutation (93 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (120 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

immune system
• mice develop diabetes (blood glucose >250 ml/dl) more rapidly than transgenic Rag1-null, Ins2-sufficient mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:111874




Genotype
MGI:3687164
cx11
Allelic
Composition
H2g7/H2g7
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (120 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells

immune system
• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells
• 15% of mice heterozygous for H2g7 develop diabetes, compared to 50% of homozygous mice or 0% of non-H2g7 mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:111874




Genotype
MGI:3687169
cx12
Allelic
Composition
H2g7/H2g7
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• insulitis is observed in some mice at 44 weeks but nor insulin autoantibodies are detected

immune system
• insulitis is observed in some mice at 44 weeks but nor insulin autoantibodies are detected
• transgenic Rag1-sufficient mice do not develop diabetes




Genotype
MGI:3687165
cx13
Allelic
Composition
H2g7/H2q
Rag1tm1Mom/Rag1tm1Mom
Tg(TcraBDC12-4.1)10Jos/0
Tg(TcrbBDC12-4.1)82Gse/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * FVB * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
H2q mutation (5 available); any H2 mutation (276 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (120 available)
Tg(TcraBDC12-4.1)10Jos mutation (2 available)
Tg(TcrbBDC12-4.1)82Gse mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 15% of mice heterozygous for the H2 alleles develop diabetes by 44 weeks

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:111874




Genotype
MGI:3842820
cx14
Allelic
Composition
H2b/H2g7
Tg(TcraR28,TcrbR28)KRNDim/0
Genetic
Background
involves: C57BL/6 * NOD * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (24 available); any H2 mutation (276 available)
H2g7 mutation (23 available); any H2 mutation (276 available)
Tg(TcraR28,TcrbR28)KRNDim mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mitral valve inflammation begins at 3 weeks of age and by 8 weeks, accumulation of inflammatory cells and interstitial thickening is obvious indicating fibroinflammatory mitral valve disease
• mononuclear phagocytes (macrophages and monocytes) constitute the vast majority of accumulated leukocytes
• frequency of TNF- and IL-6-producing phagocytes in inflamed mitral valve tissue is elevated, indicating an enrichment of cytokine-producing phagocytes within the inflamed mitral valves
• antibody blockade of either TNF or IL-6 beginning at the onset of mitral valve inflammation reduces mitral valve fibrosis and thickening
• rheumatoid arthritis occurs with disease onset transpiring between 25 and 35 days of age (J:36815)
• arthritis occurrence is established by joint inspection and measure of ankle thickness, and histological confirmation in several mice (J:36815)

cardiovascular system
• mitral valve hydroxyproline content is elevated
• by 8 weeks of age, mitral valves are fibrotic and thickened
• TNFR2 neutralization with a monoclonal antibody exacerbates mitral valve fibrosis and thickening
• blockade of either VLA-4 or VCAM-1 with monoclonal antibodies attenuates valve fibrosis and thickening
• mitral valve inflammation begins at 3 weeks of age and by 8 weeks, accumulation of inflammatory cells and interstitial thickening is obvious indicating fibroinflammatory mitral valve disease
• mononuclear phagocytes (macrophages and monocytes) constitute the vast majority of accumulated leukocytes
• frequency of TNF- and IL-6-producing phagocytes in inflamed mitral valve tissue is elevated, indicating an enrichment of cytokine-producing phagocytes within the inflamed mitral valves
• antibody blockade of either TNF or IL-6 beginning at the onset of mitral valve inflammation reduces mitral valve fibrosis and thickening

homeostasis/metabolism
• mitral valve hydroxyproline content is elevated

skeleton
• rheumatoid arthritis occurs with disease onset transpiring between 25 and 35 days of age (J:36815)
• arthritis occurrence is established by joint inspection and measure of ankle thickness, and histological confirmation in several mice (J:36815)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
mitral valve disease DOID:61 J:275827
rheumatoid arthritis DOID:7148 OMIM:180300
J:36815




Genotype
MGI:5463746
cx15
Allelic
Composition
H2g7/H2g7
Tg(Ins2-Vtcn1)#Xxz/0
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic
Background
involves: C57BL/6 * NOD * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (23 available); any H2 mutation (276 available)
Tg(Ins2-Vtcn1)#Xxz mutation (0 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• from CD4+ pancreatic T cells
• from CD4+ pancreatic T cells
• diabetes disease progression is abrogated compared to in control mice
• however, mice develop insulitis

hematopoietic system





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory