Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Tg(Cdh5-cre/ERT2)1Rha mutation
(3 available)
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cardiovascular system
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• lumens of large arteries show a reduction in diameters after tamoxifen induction at E18.5, with no significant differences in arterial wall thickness
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• lumen shows a reduction in diameter compared to controls
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• significant increase in capillary branch points in the skin is observed at E17.5
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• significant increase in capillary branch points in the skin is observed at E17.5
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integument
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• significant increase in capillary branch points in the skin is observed at E17.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Tg(KRT5-cre)1Tak mutation
(0 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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immune system
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N |
• T cells in the thymus were unaffected
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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hematopoietic system
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• absence of marginal zone B cells
• other populations of B cells as well as T cells in the spleen are normal, and B and T cell populations in the lymph nodes are normal
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immune system
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• absence of marginal zone B cells
• other populations of B cells as well as T cells in the spleen are normal, and B and T cell populations in the lymph nodes are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• nephron development is mildly disrupted
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hearing/vestibular/ear
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• hair cells in Dll1 conditional knockouts differentiate prematurely and hair cells can be seen in the apex of the cochlea at E17.5, while none are visible in control littermates
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• by E17.5 and the inner hair-cell row seems to have been duplicated in the apex
• in rhw middle and basal regions, there are increased numbers of inner hair cells
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• in the apex, between 6 and 8 rows of outer hair cells have formed in the mutant by E17.5
• in rhw middle and basal regions, there is one extra row of outer hair cells
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• at E17.5, there are fewer turns in the cochlea in the mutant compared to wild-type and in mutants the cochlea has a shorter length with an extreme broadening of the sensory patch at the apex
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• the utricular macula is severely reduced or lost
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• the saccular macula is severely reduced or lost
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nervous system
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• hair cells in Dll1 conditional knockouts differentiate prematurely and hair cells can be seen in the apex of the cochlea at E17.5, while none are visible in control littermates
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• by E17.5 and the inner hair-cell row seems to have been duplicated in the apex
• in rhw middle and basal regions, there are increased numbers of inner hair cells
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• in the apex, between 6 and 8 rows of outer hair cells have formed in the mutant by E17.5
• in rhw middle and basal regions, there is one extra row of outer hair cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Jag1tm1Frad mutation
(0 available);
any
Jag1 mutation
(76 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• nephron number is severely compromised, but some podocytes form
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Jag1tm1Frad mutation
(0 available);
any
Jag1 mutation
(76 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• almost all nephrons are absent
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Jag1tm1Frad mutation
(0 available);
any
Jag1 mutation
(76 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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• podocytes are almost entirely absent; one allele of Dll1 cannot support podocyte production
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation
(3 available);
any
Dll1 mutation
(46 available)
Jag1tm1Frad mutation
(0 available);
any
Jag1 mutation
(76 available)
Tg(Six2-EGFP/cre)1Amc mutation
(1 available)
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renal/urinary system
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N |
• nephron development appears essentially normal
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Analysis Tools