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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dll1tm1Mjo
targeted mutation 1, Michael J Owen
MGI:3044907
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Dll1tm1Mjo/Dll1tm1Mjo
Tg(Cdh5-cre/ERT2)1Rha/0
involves: 129 MGI:3848985
cn2
Dll1tm1Mjo/Dll1tm1Mjo
Tg(KRT5-cre)1Tak/?
Tg(Mx1-cre)1Cgn/?
involves: 129 * C3H * C57BL/6 * CBA MGI:3045468
cn3
Dll1tm1Mjo/Dll1tm1Mjo
Tg(Mx1-cre)1Cgn/?
involves: 129 * C57BL/6 * CBA MGI:3045467
cn4
Dll1tm1Mjo/Dll1tm1Mjo
Tg(Six2-EGFP/cre)1Amc/0
involves: 129 * C57BL/6 * CD-1 MGI:5523690
cn5
Dll1tm1Mjo/Dll1tm1Mjo
Foxg1tm1(cre)Skm/Foxg1+
involves: 129P2/OlaHsd * C57BL/6J MGI:3624333
cn6
Dll1tm1Mjo/Dll1tm1Mjo
Jag1tm1Frad/Jag1+
Tg(Six2-EGFP/cre)1Amc/0
involves: 129/Sv * C57BL/6 * CD-1 MGI:5523691
cn7
Dll1tm1Mjo/Dll1tm1Mjo
Jag1tm1Frad/Jag1tm1Frad
Tg(Six2-EGFP/cre)1Amc/0
involves: 129/Sv * C57BL/6 * CD-1 MGI:5523692
cn8
Dll1tm1Mjo/Dll1+
Jag1tm1Frad/Jag1tm1Frad
Tg(Six2-EGFP/cre)1Amc/0
involves: 129/Sv * C57BL/6 * CD-1 MGI:5523693
cn9
Dll1tm1Mjo/Dll1+
Jag1tm1Frad/Jag1+
Tg(Six2-EGFP/cre)1Amc/0
involves: 129/Sv * C57BL/6 * CD-1 MGI:5523694


Genotype
MGI:3848985
cn1
Allelic
Composition
Dll1tm1Mjo/Dll1tm1Mjo
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (1 available); any Dll1 mutation (31 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• significant increase in capillary branch points in the skin is observed at E17.5
• lumens of large arteries show a reduction in diameters after tamoxifen induction at E18.5, with no significant differences in arterial wall thickness
• lumen shows a reduction in diameter compared to controls




Genotype
MGI:3045468
cn2
Allelic
Composition
Dll1tm1Mjo/Dll1tm1Mjo
Tg(KRT5-cre)1Tak/?
Tg(Mx1-cre)1Cgn/?
Genetic
Background
involves: 129 * C3H * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (1 available); any Dll1 mutation (31 available)
Tg(KRT5-cre)1Tak mutation (0 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• T cells in the thymus were unaffected




Genotype
MGI:3045467
cn3
Allelic
Composition
Dll1tm1Mjo/Dll1tm1Mjo
Tg(Mx1-cre)1Cgn/?
Genetic
Background
involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (1 available); any Dll1 mutation (31 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• absence of marginal zone B cells
• other populations of B cells as well as T cells in the spleen are normal, and B and T cell populations in the lymph nodes are normal

immune system
• absence of marginal zone B cells
• other populations of B cells as well as T cells in the spleen are normal, and B and T cell populations in the lymph nodes are normal




Genotype
MGI:5523690
cn4
Allelic
Composition
Dll1tm1Mjo/Dll1tm1Mjo
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background
involves: 129 * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (1 available); any Dll1 mutation (31 available)
Tg(Six2-EGFP/cre)1Amc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• nephron development is mildly disrupted




Genotype
MGI:3624333
cn5
Allelic
Composition
Dll1tm1Mjo/Dll1tm1Mjo
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (1 available); any Dll1 mutation (31 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• hair cells in Dll1 conditional knockouts differentiate prematurely and hair cells can be seen in the apex of the cochlea at E17.5, while none are visible in control littermates
• by E17.5 and the inner hair-cell row seems to have been duplicated in the apex
• in rhw middle and basal regions, there are increased numbers of inner hair cells
• in the apex, between 6 and 8 rows of outer hair cells have formed in the mutant by E17.5
• in rhw middle and basal regions, there is one extra row of outer hair cells
• at E17.5, there are fewer turns in the cochlea in the mutant compared to wild-type and in mutants the cochlea has a shorter length with an extreme broadening of the sensory patch at the apex
• the utricular macula is severely reduced or lost
• the saccular macula is severely reduced or lost

nervous system
• hair cells in Dll1 conditional knockouts differentiate prematurely and hair cells can be seen in the apex of the cochlea at E17.5, while none are visible in control littermates
• by E17.5 and the inner hair-cell row seems to have been duplicated in the apex
• in rhw middle and basal regions, there are increased numbers of inner hair cells
• in the apex, between 6 and 8 rows of outer hair cells have formed in the mutant by E17.5
• in rhw middle and basal regions, there is one extra row of outer hair cells




Genotype
MGI:5523691
cn6
Allelic
Composition
Dll1tm1Mjo/Dll1tm1Mjo
Jag1tm1Frad/Jag1+
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background
involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (1 available); any Dll1 mutation (31 available)
Jag1tm1Frad mutation (0 available); any Jag1 mutation (11 available)
Tg(Six2-EGFP/cre)1Amc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• nephron number is severely compromised, but some podocytes form




Genotype
MGI:5523692
cn7
Allelic
Composition
Dll1tm1Mjo/Dll1tm1Mjo
Jag1tm1Frad/Jag1tm1Frad
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background
involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (1 available); any Dll1 mutation (31 available)
Jag1tm1Frad mutation (0 available); any Jag1 mutation (11 available)
Tg(Six2-EGFP/cre)1Amc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• almost all nephrons are absent




Genotype
MGI:5523693
cn8
Allelic
Composition
Dll1tm1Mjo/Dll1+
Jag1tm1Frad/Jag1tm1Frad
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background
involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (1 available); any Dll1 mutation (31 available)
Jag1tm1Frad mutation (0 available); any Jag1 mutation (11 available)
Tg(Six2-EGFP/cre)1Amc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• podocytes are almost entirely absent; one allele of Dll1 cannot support podocyte production




Genotype
MGI:5523694
cn9
Allelic
Composition
Dll1tm1Mjo/Dll1+
Jag1tm1Frad/Jag1+
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background
involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll1tm1Mjo mutation (1 available); any Dll1 mutation (31 available)
Jag1tm1Frad mutation (0 available); any Jag1 mutation (11 available)
Tg(Six2-EGFP/cre)1Amc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
N
• nephron development appears essentially normal





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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory