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Allele Symbol Allele Name Allele ID |
Bmp4tm1Jfm targeted mutation 1, James F Martin MGI:3041440 |
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| Summary |
22 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no embryos are found after E12.5
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• dramatic reduction in the amount of sarcomeric myosin
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• defect in outflow tract remodeling at E12.5 due to a deficiency in proximal outflow tract mesenchyme
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• at E14.5 and E18.5, a deficiency in the separation of the proximal outflow tract is seen
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• at E14.5 and E18.5, the alignment of the aorta and pulmonary trunk is abnormal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• severely reduced outflow tract cushions, which developed into a shortened outflow tract
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice died by E13.5, although an occasional fetus survived to E18.5, putatively due to variability in the expression of cre recombinase
• peripheral edema that was often associated with pericardial effusion indicated that lethality was secondary to heart failure
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• severe defects in the architecture of the brancial arch artery due to impaired remodeling
• variable branching and abnormal regression and remodeling
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• only one pulmonary artery originates from the ductus arteriosis and the fate of the second pulmonary artery is not clear
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• majority exhibited a proximal aortopulmonary window, in which the proximal aspect of the outflow tract septum failed to form
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• the left carotid artery branched either from the right brachiocephalic artery in the most severely affected embryos or directly from the aorta in more mildly affected embryos
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• interruption (type B) of the aorta between the left carotid and the left subclavian arteries
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• growth was delayed and the cushions were hypoplastic
• cell proliferation is reduced in the cushion mesenchyme, relative to wild-type
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• observed in all examined fetuses
• putatively due to a defect in the conotruncal mesenchyme
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• hypoplastic semilunar valves
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• peripheral edema that was often associated with pericardial effusion
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• peripheral edema that was often associated with pericardial effusion
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• peripheral edema that was often associated with pericardial effusion
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• severe defects in the architecture of the brancial arch artery due to impaired remodeling
• variable branching and abnormal regression and remodeling
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• severe defects in the architecture of the brancial arch artery due to impaired remodeling
• variable branching and abnormal regression and remodeling
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• proximal outflow tract mesenchyme deficiency is more severe than in mutant mice wild-type for Mir17-92
• failure of fusion between proximal mesenchyme and outflow tract septum
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• at E14.5 and E18.5, a deficiency in the separation of the proximal outflow tract is seen
• deficiency is more severe than in mutant mice wild-type for Mir17-92
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• drastic reduction in most cranial neural crest derived bones
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• enlarged frontal fontanelle at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
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• pieces of the interparietal bone are absent
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• mandibular defects at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
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• pieces of the nasal bone are absent
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• drastic reduction in most cranial neural crest derived bones
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• enlarged frontal fontanelle at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
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• pieces of the interparietal bone are absent
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• mandibular defects at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
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• pieces of the nasal bone are absent
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• pieces of the nasal bone are absent
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• pieces of the nasal bone are absent
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased size
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• decreased size
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased size
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• decreased size
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• missing pieces
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• missing pieces
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• missing pieces
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased size
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• missing pieces
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• decreased size
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pieces of the interparietal bone are absent
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• decreased size
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• pieces of the condyloid process are absent
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• pieces of the nasal bone are absent
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• pieces of the interparietal bone are absent
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• decreased size
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• pieces of the condyloid process are absent
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• pieces of the nasal bone are absent
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• pieces of the nasal bone are absent
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• pieces of the nasal bone are absent
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• drastic reduction in most cranial neural crest derived bones
|
|
• enlarged frontal fontanelle at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
|
|
• pieces of the interparietal bone are absent
|
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• pieces of the squamosal bone are absent
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• mandibular defects at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
|
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• decreased size
|
|
• pieces of the condyloid process are absent
|
|
• pieces of the nasal bone are absent
|
|
• drastic reduction in most cranial neural crest derived bones
|
|
• enlarged frontal fontanelle at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
|
|
• pieces of the interparietal bone are absent
|
|
• pieces of the squamosal bone are absent
|
|
• mandibular defects at E18.5
• phenotype is more severe than in conditional null mice wild-type for Bmp2
|
|
• decreased size
|
|
• pieces of the condyloid process are absent
|
|
• pieces of the nasal bone are absent
|
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• pieces of the nasal bone are absent
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• pieces of the nasal bone are absent
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• expression analysis indicates a defect in the transition from pre-osteoblast to osteoblast
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• enlarged frontal fontanelle at E18.5
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• subtle mandibular defects at E18.5
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• expression analysis indicates a defect in the transition from pre-osteoblast to osteoblast
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• enlarged frontal fontanelle at E18.5
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• subtle mandibular defects at E18.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• enlarged frontal fontanelle at E18.5
|
|
• decreased size
|
|
• subtle mandibular defects at E18.5
|
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• enlarged frontal fontanelle at E18.5
|
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• decreased size
|
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• subtle mandibular defects at E18.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants show no defects in limb patterning and skeletogenesis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects
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• AER is expanded and maintained much later (>E15.5) than in wild-type
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• at E11.5, limb buds are noticeably broader relative to wild-type
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• has not yet started at birth
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• interdigital apoptosis is reduced at E15.5
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• AER is expanded and maintained much later (>E15.5) than in wild-type
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• at E11.5, limb buds are noticeably broader relative to wild-type
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• at E15.5 autopod adopts notched pallet form, with only distal tip of each digit separated
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• autopod elements are reduced in size
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• the two posterior-most digits are missing in the forelimbs
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• in newborns, the digits of both forelimb and hindlimb show complete syndactyly
• in the limbs of E15.5 embryos, only the very distal tip of each digit is separated, with the autopod adopting the shape of a notched pallet
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• mice have short and malformed stylopods
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• one of the zeugopod elements is almost always missing, while the other is so deformed it is hard to accurately identify
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• mice have short and malformed stylopods
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• one of the zeugopod elements is almost always missing, while the other is so deformed it is hard to accurately identify
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• at 3 weeks, all mineralized cartilage in diaphyseal region has disappeared, leaving a void where bone formation should have occurred
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• cavity formation is delayed
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• loss of posterior digits in the forelimbs due to failure of chondrogenesis in this region as indicated by marker analysis
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• joint articulations are defective such that the zeugopod and stylopod elements are fused
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• 1-3 weeks after birth, no bone marrow cavity, trabecular bone, or cortical bone is present
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• at 1-3 weeks after birth , bone formation is not observed in femur for example; skeletal elements in mutants remain similar to E17.5 structures seen in wild-type limbs
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• in E17.5 limbs, delay in endochondral process is observed; bone morphology at birth resembles E17.5 in wild-type
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• interdigital apoptosis is reduced at E15.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects
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• mice exhibit variable penetrance of preaxial and postaxial polydactyly, however exhibit normal digit patterns
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects
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• mice have more severe skeletal defects than Bmp2-heterozygous, Bmp4-homozygous mice, including significantly thinner skeletal elements
• animals do not have abnormal digit patterns
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects
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• mice exhibit variable penetrance pre- and postaxial syndactyly
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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