reproductive system
N |
• mice are healthy and fertile
|
endocrine/exocrine glands
|
• as early as 2 to 4 months of age
• however, thymectomy rescues defect
|
|
• as early as 2 months of age and increasing in severity with age
|
|
• aged mice exhibit destruction of lacrimal gland tissue with opaque spots unlike wild-type mice
|
|
• as early as 2 months of age prior to eye abnormalities
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immune system
N |
• peripheral lymphocytes are normal
|
|
• as early as 2 months of age and increasing in severity with age
|
|
• as early as 2 months of age prior to eye abnormalities
|
|
• at 1 year of age, mice exhibit increased levels of SSA and SSB autoantibodies compared with wild-type mice
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vision/eye
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• as early as 2 months of age prior to eye abnormalities
|
|
• at 6 to 10 months of age, 13 of 102 mice exhibit difficulties in maintaining fully opened eyelids due to skin lesions around the eyes unlike wild-type mice
• after 1 year, 35 of 41 mice exhibit eye abnormalities compared with wild-type mice
|
|
• aged mice exhibit destruction of lacrimal gland tissue with opaque spots unlike wild-type mice
|
|
• as early as 2 to 4 months of age, mice exhibit reduced tear production compared with wild-type mice
• however, thymectomy rescues defect
|
digestive/alimentary system
|
• as early as 2 to 4 months of age
• however, thymectomy rescues defect
|
|
• as early as 2 months of age and increasing in severity with age
|
homeostasis/metabolism