Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf14tm1Kpf mutation
(2 available);
any
Tnfsf14 mutation
(25 available)
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skeleton
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• increase in osteoclast formation in ex vivo bone marrow cell cultures
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• end plates show disorganization of the chondrocyte columns
• chondrocyte columns are reduced in height in the hypertrophic zone and in the number of cells in the proliferative zone
• however, morphology of lumbar vertebrae do not appear abnormal
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• deformity in the curvature of the spine at thoracic vertebrae in 40% of newborns
• abnormal curvature persists overtime
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• significant decrease in bone formation parameters in cranial and femoral cortical and cancellous bone by dynamic histomorphometry analysis
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• severely reduced structure in the femur at 1, 3, 6, and 12 months of age
• significant decrease in bone formation parameters in cranial and femoral cortical and cancellous bone by dynamic histomorphometry analysis
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• end plates show disorganization of the chondrocyte columns in the thoracic vertebrae
• in thoracic vertebrae chondrocyte columns are reduced in height in the hypertrophic zone and in the number of cells in the proliferative zone
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cellular
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• increase in osteoclast formation in ex vivo bone marrow cell cultures
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hematopoietic system
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• increase in osteoclast formation in ex vivo bone marrow cell cultures
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immune system
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• increase in osteoclast formation in ex vivo bone marrow cell cultures
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf14tm1Kpf mutation
(2 available);
any
Tnfsf14 mutation
(25 available)
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hematopoietic system
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• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells
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immune system
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• fewer IL17+ thymic gamma-delta T cells in response to PMA and ionomycin stimulation
• however, the number of thymic IFN-gamma+ gamma-delta T cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf14tm1Kpf mutation
(2 available);
any
Tnfsf14 mutation
(25 available)
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immune system
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• T cells show reduced proliferation after anti-CD3 antibody stimulation
• proliferation of CD4-depleted splenocytes after allogeneic MLR activation is reduced, while CD8-depleted splenocytes show no differences
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• splenocytes show reduced proliferation after anti-CD3 stimulation
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• CD8/CD4 ratios of MLR-activated responder T cells are reduced by 40% on day 5 compared to wild-type splenocytes, however the ratio of naive splenocytes is similar to controls
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• effector splenocytes show a reduction in specific target cell lysis compared to heterozygotes
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• after allogeneic mixed lymphocyte reactive (MLR) activation
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• after allogeneic MLR activation
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• after allogeneic MLR activation
• production of IL-2 from CD8-depleted splenocytes after allogeneic MLR activation is reduced
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• after allogeneic MLR activation
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hematopoietic system
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• T cells show reduced proliferation after anti-CD3 antibody stimulation
• proliferation of CD4-depleted splenocytes after allogeneic MLR activation is reduced, while CD8-depleted splenocytes show no differences
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• splenocytes show reduced proliferation after anti-CD3 stimulation
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• CD8/CD4 ratios of MLR-activated responder T cells are reduced by 40% on day 5 compared to wild-type splenocytes, however the ratio of naive splenocytes is similar to controls
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• effector splenocytes show a reduction in specific target cell lysis compared to heterozygotes
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cellular
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• T cells show reduced proliferation after anti-CD3 antibody stimulation
• proliferation of CD4-depleted splenocytes after allogeneic MLR activation is reduced, while CD8-depleted splenocytes show no differences
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• splenocytes show reduced proliferation after anti-CD3 stimulation
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immune system
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• mutants show a longer skin graft survival of about 6 days than wild-type mice or single homozygotes
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skeleton
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• increase in cancellous bone structure in comparison to mice null for Rag alone
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hematopoietic system
immune system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltbtm1Kpf mutation
(0 available);
any
Ltb mutation
(18 available)
Tnfsf14tm1Kpf mutation
(2 available);
any
Tnfsf14 mutation
(25 available)
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immune system
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• abnormal spleen architecture, with T cells accumulating around the central arteriole surrounded by a wall of B cells
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• only 4 out of 16 mutants have mesenteric lymph nodes
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• absent brachial, axillary, inguinal, popliteal, paraaortic, and parapancreatic lymph nodes
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hematopoietic system
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• abnormal spleen architecture, with T cells accumulating around the central arteriole surrounded by a wall of B cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tnfsf13b)1Fma mutation
(0 available)
Tnfsf14tm1Kpf mutation
(2 available);
any
Tnfsf14 mutation
(25 available)
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hematopoietic system
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• a marked increase in some B cell subsets compared to wild-type is detected in 12 week old mice
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• there is an increased frequency of B220neg/lo, IgA+ plasma cells in lamina propria preparations
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• numerous germinal centers are observed in B cell follicles of mutants
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• splenic marginal zone is increased in size
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• augmented IgA staining is found in lamina propria of mutants
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renal/urinary system
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• in 8-month old mice, some thickening of mesangial and basement membranes
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• deposition of IgA in nearly all glomeruli is detected, similar to Tnfsf14-sufficient transgenic mice
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immune system
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• a marked increase in some B cell subsets compared to wild-type is detected in 12 week old mice
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• there is an increased frequency of B220neg/lo, IgA+ plasma cells in lamina propria preparations
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• numerous germinal centers are observed in B cell follicles of mutants
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• splenic marginal zone is increased in size
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• augmented IgA staining is found in lamina propria of mutants
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cellular
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• in 8-month old mice, some thickening of mesangial and basement membranes
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Analysis Tools