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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ezh2tm1Tara
targeted mutation 1, Alexander Tarakhovsky
MGI:2661097
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ezh2tm1Tara/Ezh2tm1Tara involves: 129P2/OlaHsd MGI:2661105
cn2
 		Ezh1tm1Jnw/Ezh1tm1Jnw
Ezh2tm1Tara/Ezh2tm1Tara
Tg(KRT14-cre)1Efu/0 		involves: 129P2/OlaHsd MGI:4941024
cn3
 		Ezh2tm1Tara/Ezh2tm1Tara
Cd19tm1(cre)Cgn/? 		involves: 129P2/OlaHsd MGI:4440626
cn4
 		Ezh2tm1Tara/Ezh2tm1Tara
Ighg1tm1(cre)Cgn/Ighg1+ 		involves: 129P2/OlaHsd MGI:5519931
cn5
 		Ezh2tm1Tara/Ezh2tm1Tara
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:2661102
cn6
 		Ezh2tm1Tara/Ezh2tm1Tara
Ightm2Cgn/?
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4440625
cn7
 		Ezh2tm1Tara/Ezh2tm1Tara
Tg(Camk2a-cre)2Gsc/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4418573


Genotype
MGI:2661105
hm1
Allelic
Composition		 Ezh2tm1Tara/Ezh2tm1Tara
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2tm1Tara mutation (2 available); any Ezh2 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:83216 )
• mice are viable and fertile




Genotype
MGI:4941024
cn2
Allelic
Composition		 Ezh1tm1Jnw/Ezh1tm1Jnw
Ezh2tm1Tara/Ezh2tm1Tara
Tg(KRT14-cre)1Efu/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh1tm1Jnw mutation (1 available); any Ezh1 mutation (34 available)
Ezh2tm1Tara mutation (2 available); any Ezh2 mutation (71 available)
Tg(KRT14-cre)1Efu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased hair follicle apoptosis ( J:169295 )
• hair follicle cells exhibit increased apoptosis unlike wild-type cells

mortality/aging
neonatal lethality, complete penetrance ( J:169295 )
• mice die within 24 hours of birth

integument
integument phenotype ( J:169295 )
N
• mice do not exhibit skin inflammation
increased hair follicle apoptosis ( J:169295 )
• hair follicle cells exhibit increased apoptosis unlike wild-type cells
abnormal hair growth ( J:169295 )
• hair follicles in skin grafts arrest in the first growth phase of the hair cycle
• skin grafts on nude mice remain hairless unlike wild-type grafts
abnormal hair follicle infundibulum morphology ( J:169295 )
• skin grafts exhibit hyperproliferation in the infundibulum compared with wild-type cells
abnormal hair follicle outer root sheath morphology ( J:169295 )
• hair follicle stem cells in the lower outer root sheath zone exhibit decreased proliferation compared with wild-type cells
hair follicle degeneration ( J:169295 )
• hair follicle stem cells in the lower outer root sheath zone exhibit decreased proliferation regardless of stimulation compared with wild-type cells
small hair follicles ( J:169295 )
• hair follicles in skin grafts arrest in the first growth phase of the hair cycle

behavior/neurological




Genotype
MGI:4440626
cn3
Allelic
Composition		 Ezh2tm1Tara/Ezh2tm1Tara
Cd19tm1(cre)Cgn/?
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Ezh2tm1Tara mutation (2 available); any Ezh2 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:83216 )
N
• mice exhibit normal B cell development and normal in vitro proliferation of splenic B cells in response to anti-IgM F(ab)2, anti-CD40 or LPS




Genotype
MGI:5519931
cn4
Allelic
Composition		 Ezh2tm1Tara/Ezh2tm1Tara
Ighg1tm1(cre)Cgn/Ighg1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2tm1Tara mutation (2 available); any Ezh2 mutation (71 available)
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:199122 )
N
• mice exhibit normal marginal zone and follicular B cells
decreased B cell proliferation ( J:199122 )
• reduced germinal center B cell compartment proliferation following injection of antigen sheep red blood cells
decreased germinal center B cell number ( J:199122 )
• following injection of antigen sheep red blood cells or immunization with NP-KLH
decreased spleen germinal center number ( J:199122 )
• following injection of antigen sheep red blood cells
decreased spleen germinal center size ( J:199122 )
• following injection of antigen sheep red blood cells
decreased IgG1 level ( J:199122 )
• following immunization with NP-KLH
decreased IgG2b level ( J:199122 )
• following immunization with NP-KLH
decreased IgG3 level ( J:199122 )
• following immunization with NP-KLH

hematopoietic system
decreased B cell proliferation ( J:199122 )
• reduced germinal center B cell compartment proliferation following injection of antigen sheep red blood cells
decreased germinal center B cell number ( J:199122 )
• following injection of antigen sheep red blood cells or immunization with NP-KLH
decreased spleen germinal center number ( J:199122 )
• following injection of antigen sheep red blood cells
decreased spleen germinal center size ( J:199122 )
• following injection of antigen sheep red blood cells
decreased IgG1 level ( J:199122 )
• following immunization with NP-KLH
decreased IgG2b level ( J:199122 )
• following immunization with NP-KLH
decreased IgG3 level ( J:199122 )
• following immunization with NP-KLH

cellular
decreased B cell proliferation ( J:199122 )
• reduced germinal center B cell compartment proliferation following injection of antigen sheep red blood cells




Genotype
MGI:2661102
cn5
Allelic
Composition		 Ezh2tm1Tara/Ezh2tm1Tara
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2tm1Tara mutation (2 available); any Ezh2 mutation (71 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:83216 )
• mice injected with poly(I)poly(C) show a decrease in numbers of pre-B (IgM-B220+CD43-) and immature B cells (IgM+B220int), indicating impaired pro-B to pre-B cell transition
decreased immature B cell number ( J:83216 )
• mice injected with poly(I)poly(C) show a decrease in numbers of immature B cells (IgM+B220int)
abnormal immunoglobulin V(D)J recombination ( J:83216 )
• recombination of VHJ558 segments is reduced to 25% of the control
abnormal pro-B cell morphology ( J:83216 )
• pro-B cells do not form a well-defined population of B220int, intracellular mu+ cells and the overall frequency of B220+, intracellular mu+ cells is reduced to 30%
decreased pre-B cell number ( J:83216 )
• mice injected with poly(I)poly(C) show a decrease in numbers of pre-B (IgM-B220+CD43-)

immune system
abnormal B cell differentiation ( J:83216 )
• mice injected with poly(I)poly(C) show a decrease in numbers of pre-B (IgM-B220+CD43-) and immature B cells (IgM+B220int), indicating impaired pro-B to pre-B cell transition
decreased immature B cell number ( J:83216 )
• mice injected with poly(I)poly(C) show a decrease in numbers of immature B cells (IgM+B220int)
abnormal immunoglobulin V(D)J recombination ( J:83216 )
• recombination of VHJ558 segments is reduced to 25% of the control
abnormal pro-B cell morphology ( J:83216 )
• pro-B cells do not form a well-defined population of B220int, intracellular mu+ cells and the overall frequency of B220+, intracellular mu+ cells is reduced to 30%
decreased pre-B cell number ( J:83216 )
• mice injected with poly(I)poly(C) show a decrease in numbers of pre-B (IgM-B220+CD43-)




Genotype
MGI:4440625
cn6
Allelic
Composition		 Ezh2tm1Tara/Ezh2tm1Tara
Ightm2Cgn/?
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2tm1Tara mutation (2 available); any Ezh2 mutation (71 available)
Ightm2Cgn mutation (1 available); any Igh mutation (43 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:83216 )
N
• mice injected with poly(I)poly(C) exhibit normal B cell development




Genotype
MGI:4418573
cn7
Allelic
Composition		 Ezh2tm1Tara/Ezh2tm1Tara
Tg(Camk2a-cre)2Gsc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2tm1Tara mutation (2 available); any Ezh2 mutation (71 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:155739 )
N
• no behavioral abnormalities are observed




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory