About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnftm2Gkl
targeted mutation 2, George Kollias
MGI:2388715
Summary 26 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnftm2Gkl/Tnftm2Gkl involves: 129S/SvEv * C57BL/6 MGI:3622060
ht2
Tnftm2Gkl/Tnf+ B6.129S-Tnftm2Gkl/Jarn MGI:5702925
ht3
Tnftm2Gkl/Tnf+ involves: 129S/SvEv * C57BL/6 MGI:3622061
ht4
Tnftm2Gkl/Tnf+ involves: 129S/SvEv * C57BL/6 * CBA MGI:3775436
ht5
Tnftm2Gkl/Tnf+ involves: 129S/SvEv * C57BL/6J MGI:3629514
ht6
Tnftm2Gkl/Tnf+ involves: 129S/SvEv * C57BL/6 * SPRET/Ei MGI:3622071
ht7
Tnftm1Gkl/Tnftm2Gkl involves: 129S/SvEv * C57BL/6 MGI:3622062
cn8
Tnftm2Gkl/Tnf+
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(Col6a1-cre)1Gkl/?
involves: 129S/SvEv * C57BL/6 * CBA MGI:3775437
cx9
Mapk11tm1Jsca/Mapk11tm1Jsca
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3622058
cx10
Tnftm2Gkl/Tnftm2Gkl
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3622063
cx11
Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J MGI:3629603
cx12
Mapk9tm1Flv/Mapk9tm1Flv
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J MGI:3629608
cx13
Map3k8tm1Pnt/Map3k8tm1Pnt
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J MGI:3629606
cx14
Tcrdtm1Mom/Tcrdtm1Mom
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J MGI:3629523
cx15
Cd44tm1Hbg/Cd44+
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5702939
cx16
Cd44tm1Hbg/Cd44tm1Hbg
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5702938
cx17
Il12btm1Jm/Il12btm1Jm
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S1/Sv * C57BL/6J MGI:3629590
cx18
Tnftm2Gkl/Tnf+
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 MGI:3622064
cx19
Ccr9tm1.1Mal/Ccr9tm1.1Mal
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 MGI:3799634
cx20
Ccl25tm1Mal/Ccl25tm1Mal
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 MGI:3799633
cx21
Ighmtm1Cgn/Ighmtm1Cgn
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J MGI:3629519
cx22
Cd4tm1Mak/Cd4tm1Mak
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J MGI:3629516
cx23
B2mtm1Jae/B2mtm1Jae
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J MGI:3629515
cx24
Rag1tm1Mom/Rag1tm1Mom
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 MGI:3622066
cx25
Ifngtm1Ts/Ifngtm1Ts
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J MGI:3629594
cx26
Itgb7tm1Cgn/Itgb7tm1Cgn
Tnftm2Gkl/Tnf+
involves: 129S/SvEv * C57BL/6 MGI:3799636


Genotype
MGI:3622060
hm1
Allelic
Composition
Tnftm2Gkl/Tnftm2Gkl
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between 5 and 12 weeks of age (J:54056)
• die between 5 and 12 weeks of age (J:54056)

immune system
• first detected between 2 and 4 weeks of age as mucosal abnormalities with intestinal villous blunting and broadening generally confined to the terminal ileum (J:54056)
• becomes severe by 4 weeks, with increased numbers of submucosal lymphoid aggregates and follicles eventually penetrating deep into the muscular layers of the bowel wall (J:54056)
• first detected between 2 and 4 weeks of age as mucosal abnormalities with intestinal villous blunting and broadening generally confined to the terminal ileum (J:54056)
• becomes severe by 4 weeks, with increased numbers of submucosal lymphoid aggregates and follicles eventually penetrating deep into the muscular layers of the bowel wall (J:54056)
• severe hypoplasia with atrophy and disorganization of the cortical and medullary areas is seen at 4 weeks of age; however at 12 days of age the ratio of thymic and peripheral T cell subsets is normal (J:54056)
• severe hypoplasia with atrophy and disorganization of the cortical and medullary areas is seen at 4 weeks of age; however at 12 days of age the ratio of thymic and peripheral T cell subsets is normal (J:54056)
• at 6 weeks of age circulating levels of TNF are up to 822 +/- 447 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• at 6 weeks of age circulating levels of TNF are up to 822 +/- 447 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• develop signs of chronic polyarthritis including joint swelling, distortion of fore and hind paw morphology, impaired movement (J:54056)
• disease onset occurs at 12 days of age (J:54056)
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction (J:54056)
• both IgM and IgG are detected in arthritic joints (J:54056)
• develop signs of chronic polyarthritis including joint swelling, distortion of fore and hind paw morphology, impaired movement (J:54056)
• disease onset occurs at 12 days of age (J:54056)
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction (J:54056)
• both IgM and IgG are detected in arthritic joints (J:54056)

growth/size/body
• body weight does no exceed 6-7 g (J:54056)
• body weight does no exceed 6-7 g (J:54056)

digestive/alimentary system
• first detected between 2 and 4 weeks of age as mucosal abnormalities with intestinal villous blunting and broadening generally confined to the terminal ileum (J:54056)
• becomes severe by 4 weeks, with increased numbers of submucosal lymphoid aggregates and follicles eventually penetrating deep into the muscular layers of the bowel wall (J:54056)
• first detected between 2 and 4 weeks of age as mucosal abnormalities with intestinal villous blunting and broadening generally confined to the terminal ileum (J:54056)
• becomes severe by 4 weeks, with increased numbers of submucosal lymphoid aggregates and follicles eventually penetrating deep into the muscular layers of the bowel wall (J:54056)

skeleton
• develop signs of chronic polyarthritis including joint swelling, distortion of fore and hind paw morphology, impaired movement (J:54056)
• disease onset occurs at 12 days of age (J:54056)
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction (J:54056)
• both IgM and IgG are detected in arthritic joints (J:54056)
• develop signs of chronic polyarthritis including joint swelling, distortion of fore and hind paw morphology, impaired movement (J:54056)
• disease onset occurs at 12 days of age (J:54056)
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction (J:54056)
• both IgM and IgG are detected in arthritic joints (J:54056)

hematopoietic system
• severe hypoplasia with atrophy and disorganization of the cortical and medullary areas is seen at 4 weeks of age; however at 12 days of age the ratio of thymic and peripheral T cell subsets is normal (J:54056)
• severe hypoplasia with atrophy and disorganization of the cortical and medullary areas is seen at 4 weeks of age; however at 12 days of age the ratio of thymic and peripheral T cell subsets is normal (J:54056)

homeostasis/metabolism
• at 6 weeks of age circulating levels of TNF are up to 822 +/- 447 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• at 6 weeks of age circulating levels of TNF are up to 822 +/- 447 pg/ml compared to undetectable levels in wild-type mice (J:54056)

endocrine/exocrine glands
• severe hypoplasia with atrophy and disorganization of the cortical and medullary areas is seen at 4 weeks of age; however at 12 days of age the ratio of thymic and peripheral T cell subsets is normal (J:54056)
• severe hypoplasia with atrophy and disorganization of the cortical and medullary areas is seen at 4 weeks of age; however at 12 days of age the ratio of thymic and peripheral T cell subsets is normal (J:54056)

Mouse Models of Human Disease
OMIM ID Ref(s)
Rheumatoid Arthritis; RA 180300 J:54056




Genotype
MGI:5702925
ht2
Allelic
Composition
Tnftm2Gkl/Tnf+
Genetic
Background
B6.129S-Tnftm2Gkl/Jarn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• antibody depletion of CD8+ T cells does not improve ileitis (J:131978)
• antibody depletion of CD8+ T cells does not improve ileitis (J:131978)
• with increased levels of soluble hyaluronan (J:145626)
• with increased levels of soluble hyaluronan (J:145626)
• increased percentage of CD4+/CD44high T cells in populations from the spleen, mesenteric lymph nodes and lamina propria by 20 weeks of age (J:145626)
• increased percentage of CD4+/CD44high T cells in populations from the spleen, mesenteric lymph nodes and lamina propria by 20 weeks of age (J:145626)
• CD8+ population polarized into CD44high/CD103low and CD44low/CD103high subsets in mice with advanced disease (J:131978)
• CD8+ population polarized into CD44high/CD103low and CD44low/CD103high subsets in mice with advanced disease (J:131978)
• increased reactivity and rolling flux fraction (J:145626)
• increased reactivity and rolling flux fraction (J:145626)
• in CD8+/CD44high T cells (J:131978)
• in CD8+/CD44high T cells (J:131978)
• in CD4+/CD44high T cells (J:145626)
• in CD4+/CD44high T cells (J:145626)
• in CD4+/CD44high T cells (J:145626)
• in CD4+/CD44high T cells (J:145626)

digestive/alimentary system
• antibody depletion of CD8+ T cells does not improve ileitis (J:131978)
• antibody depletion of CD8+ T cells does not improve ileitis (J:131978)
• with increased levels of soluble hyaluronan (J:145626)
• with increased levels of soluble hyaluronan (J:145626)

hematopoietic system
• increased percentage of CD4+/CD44high T cells in populations from the spleen, mesenteric lymph nodes and lamina propria by 20 weeks of age (J:145626)
• increased percentage of CD4+/CD44high T cells in populations from the spleen, mesenteric lymph nodes and lamina propria by 20 weeks of age (J:145626)
• CD8+ population polarized into CD44high/CD103low and CD44low/CD103high subsets in mice with advanced disease (J:131978)
• CD8+ population polarized into CD44high/CD103low and CD44low/CD103high subsets in mice with advanced disease (J:131978)
• increased reactivity and rolling flux fraction (J:145626)
• increased reactivity and rolling flux fraction (J:145626)




Genotype
MGI:3622061
ht3
Allelic
Composition
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• elevated chronic and acute inflammatory indices (J:136667)
• elevated chronic and acute inflammatory indices (J:136667)
• first detected between 2 and 4 weeks of age as mucosal abnormalities with intestinal villous blunting and broadening generally confined to the terminal ileum (J:54056)
• becomes severe by 8 weeks, with increased numbers of submucosal lymphoid aggregates and follicles eventually penetrating deep into the muscular layers of the bowel wall (J:54056)
• by 4-7 months of age complete loss of villous structure and rudimental granulomata are seen (J:54056)
• first detected between 2 and 4 weeks of age as mucosal abnormalities with intestinal villous blunting and broadening generally confined to the terminal ileum (J:54056)
• becomes severe by 8 weeks, with increased numbers of submucosal lymphoid aggregates and follicles eventually penetrating deep into the muscular layers of the bowel wall (J:54056)
• by 4-7 months of age complete loss of villous structure and rudimental granulomata are seen (J:54056)
• at 9 months similar bowel inflammation extending into the mucosal layers and loss of crypt morphology is seen in mice on a mixed background with or without SPRET/Ei (J:92307)
• at 9 months similar bowel inflammation extending into the mucosal layers and loss of crypt morphology is seen in mice on a mixed background with or without SPRET/Ei (J:92307)
• mutants on a high-fat diet develop accelerated onset of intestinal inflammation compared to wild-type mice (J:204922)
• mutants on a high-fat diet develop accelerated onset of intestinal inflammation compared to wild-type mice (J:204922)
• mutants show higher numbers of CD11c+ dendritic cells in the ileal lamina propria when fed a high-fat diet compared to wild-type mice (J:204922)
• mutants show higher numbers of CD11c+ dendritic cells in the ileal lamina propria when fed a high-fat diet compared to wild-type mice (J:204922)
• at 16 weeks of age, the CD8alpha alpha to CD8alpha beta ratio is significantly decreased in the lamina propria of the ileum (J:136667)
• at 16 weeks of age, the CD8alpha alpha to CD8alpha beta ratio is significantly decreased in the lamina propria of the ileum (J:136667)
• at 4 weeks of age, fewer CD8alpha alpha intraepithelial lymphocytes are present in the ileum (J:136667)
• however, no significant difference is seen in the number of CD8alpha beta intraepithelial lymphocytes (J:136667)
• at 4 weeks of age, fewer CD8alpha alpha intraepithelial lymphocytes are present in the ileum (J:136667)
• however, no significant difference is seen in the number of CD8alpha beta intraepithelial lymphocytes (J:136667)
• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers (J:136667)
• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers (J:136667)
• increase in the number of TNF-producing cells in the lamina propria and intraepithelial lymphocyte subsets (J:136667)
• increase in the number of TNF-producing cells in the lamina propria and intraepithelial lymphocyte subsets (J:136667)
• reduced expression of interferon gamma and increased expression of interleukin 17 and 10 in CD4+ lymphocytes in the lamina propria of the ileum (J:136667)
• reduced expression of interferon gamma and increased expression of interleukin 17 and 10 in CD4+ lymphocytes in the lamina propria of the ileum (J:136667)
• mutants show increased Th17-biased lymphocyte infiltration into the lamina propria of the ileum on a high-fat diet compared to wild-type mice (J:204922)
• mutants show increased Th17-biased lymphocyte infiltration into the lamina propria of the ileum on a high-fat diet compared to wild-type mice (J:204922)
• mutants exhibit increased plasma CCL20 levels on both a regular or high-fat diet compared to wild-type mice (J:204922)
• mutants exhibit increased plasma CCL20 levels on both a regular or high-fat diet compared to wild-type mice (J:204922)
• at 6 weeks of age circulating levels of TNF are up between 90 and 430 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• at 6 weeks of age circulating levels of TNF are up between 90 and 430 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• TNF plasma levels are increased at 12 weeks of age in mutants compared to wild-type mice, however high-fat diet does not result in a further increase (J:204922)
• TNF plasma levels are increased at 12 weeks of age in mutants compared to wild-type mice, however high-fat diet does not result in a further increase (J:204922)
• expression analysis indicates that mutants do not show adipose tissue inflammation when fed a high-fat diet as seen in wild-type mice (J:204922)
• expression analysis indicates that mutants do not show adipose tissue inflammation when fed a high-fat diet as seen in wild-type mice (J:204922)
• Background Sensitivity: at 9 months arthritis is severe enough to reduce mobility unlike in mice on a mixed background including SPRET/Ei (J:92307)
• at 9 months joints show extensive lymphocytic infiltration, thickening of the synovial lining, pannus formation, and abnormal ingrowth of the synovial lining (J:92307)
• Background Sensitivity: at 9 months arthritis is severe enough to reduce mobility unlike in mice on a mixed background including SPRET/Ei (J:92307)
• at 9 months joints show extensive lymphocytic infiltration, thickening of the synovial lining, pannus formation, and abnormal ingrowth of the synovial lining (J:92307)

digestive/alimentary system
• mutants show elevated fecal energy content when fed a high-fat diet, suggesting steatorrhea, which is not seen in wild-type mice (J:204922)
• mutants show elevated fecal energy content when fed a high-fat diet, suggesting steatorrhea, which is not seen in wild-type mice (J:204922)
• mutants show increased intestinal permeability when fed a high-fat diet (J:204922)
• mutants show increased intestinal permeability when fed a high-fat diet (J:204922)
• elevated chronic and acute inflammatory indices (J:136667)
• elevated chronic and acute inflammatory indices (J:136667)
• first detected between 2 and 4 weeks of age as mucosal abnormalities with intestinal villous blunting and broadening generally confined to the terminal ileum (J:54056)
• becomes severe by 8 weeks, with increased numbers of submucosal lymphoid aggregates and follicles eventually penetrating deep into the muscular layers of the bowel wall (J:54056)
• by 4-7 months of age complete loss of villous structure and rudimental granulomata are seen (J:54056)
• first detected between 2 and 4 weeks of age as mucosal abnormalities with intestinal villous blunting and broadening generally confined to the terminal ileum (J:54056)
• becomes severe by 8 weeks, with increased numbers of submucosal lymphoid aggregates and follicles eventually penetrating deep into the muscular layers of the bowel wall (J:54056)
• by 4-7 months of age complete loss of villous structure and rudimental granulomata are seen (J:54056)
• at 9 months similar bowel inflammation extending into the mucosal layers and loss of crypt morphology is seen in mice on a mixed background with or without SPRET/Ei (J:92307)
• at 9 months similar bowel inflammation extending into the mucosal layers and loss of crypt morphology is seen in mice on a mixed background with or without SPRET/Ei (J:92307)
• mutants on a high-fat diet develop accelerated onset of intestinal inflammation compared to wild-type mice (J:204922)
• mutants on a high-fat diet develop accelerated onset of intestinal inflammation compared to wild-type mice (J:204922)

skeleton
• Background Sensitivity: at 9 months arthritis is severe enough to reduce mobility unlike in mice on a mixed background including SPRET/Ei (J:92307)
• at 9 months joints show extensive lymphocytic infiltration, thickening of the synovial lining, pannus formation, and abnormal ingrowth of the synovial lining (J:92307)
• Background Sensitivity: at 9 months arthritis is severe enough to reduce mobility unlike in mice on a mixed background including SPRET/Ei (J:92307)
• at 9 months joints show extensive lymphocytic infiltration, thickening of the synovial lining, pannus formation, and abnormal ingrowth of the synovial lining (J:92307)

homeostasis/metabolism
• mutants do not develop obesity on a high-fat diet as seen in wild-type mice (J:204922)
• mutants on a high-fat diet do not show increased fat depots or enlarged adipocytes as seen in wild-type mice (J:204922)
• mutants do not develop obesity on a high-fat diet as seen in wild-type mice (J:204922)
• mutants on a high-fat diet do not show increased fat depots or enlarged adipocytes as seen in wild-type mice (J:204922)
• mutants on high-fat diet do not exhibit an increase in plasma leptin levels as seen in wild-type mice (J:204922)
• mutants on high-fat diet do not exhibit an increase in plasma leptin levels as seen in wild-type mice (J:204922)
• mutants exhibit increased plasma CCL20 levels on both a regular or high-fat diet compared to wild-type mice (J:204922)
• mutants exhibit increased plasma CCL20 levels on both a regular or high-fat diet compared to wild-type mice (J:204922)
• at 6 weeks of age circulating levels of TNF are up between 90 and 430 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• at 6 weeks of age circulating levels of TNF are up between 90 and 430 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• TNF plasma levels are increased at 12 weeks of age in mutants compared to wild-type mice, however high-fat diet does not result in a further increase (J:204922)
• TNF plasma levels are increased at 12 weeks of age in mutants compared to wild-type mice, however high-fat diet does not result in a further increase (J:204922)
• glucose homeostasis remains normal in mutants fed a high-fat diet unlike in wild-type mice which show impaired glucose tolerance and elevated fasting blood glucose (J:204922)
• glucose homeostasis remains normal in mutants fed a high-fat diet unlike in wild-type mice which show impaired glucose tolerance and elevated fasting blood glucose (J:204922)

hematopoietic system
• mutants show higher numbers of CD11c+ dendritic cells in the ileal lamina propria when fed a high-fat diet compared to wild-type mice (J:204922)
• mutants show higher numbers of CD11c+ dendritic cells in the ileal lamina propria when fed a high-fat diet compared to wild-type mice (J:204922)
• at 16 weeks of age, the CD8alpha alpha to CD8alpha beta ratio is significantly decreased in the lamina propria of the ileum (J:136667)
• at 16 weeks of age, the CD8alpha alpha to CD8alpha beta ratio is significantly decreased in the lamina propria of the ileum (J:136667)
• at 4 weeks of age, fewer CD8alpha alpha intraepithelial lymphocytes are present in the ileum (J:136667)
• however, no significant difference is seen in the number of CD8alpha beta intraepithelial lymphocytes (J:136667)
• at 4 weeks of age, fewer CD8alpha alpha intraepithelial lymphocytes are present in the ileum (J:136667)
• however, no significant difference is seen in the number of CD8alpha beta intraepithelial lymphocytes (J:136667)
• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers (J:136667)
• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers (J:136667)
• increase in the number of TNF-producing cells in the lamina propria and intraepithelial lymphocyte subsets (J:136667)
• increase in the number of TNF-producing cells in the lamina propria and intraepithelial lymphocyte subsets (J:136667)
• reduced expression of interferon gamma and increased expression of interleukin 17 and 10 in CD4+ lymphocytes in the lamina propria of the ileum (J:136667)
• reduced expression of interferon gamma and increased expression of interleukin 17 and 10 in CD4+ lymphocytes in the lamina propria of the ileum (J:136667)
• mutants show increased Th17-biased lymphocyte infiltration into the lamina propria of the ileum on a high-fat diet compared to wild-type mice (J:204922)
• mutants show increased Th17-biased lymphocyte infiltration into the lamina propria of the ileum on a high-fat diet compared to wild-type mice (J:204922)

integument
• at 9 months of age (J:92307)
• at 9 months of age (J:92307)

behavior/neurological
• mutants exhibit increased energy intake on a high-fat diet (J:204922)
• mutants exhibit increased energy intake on a high-fat diet (J:204922)

growth/size/body
• mutants do not develop obesity on a high-fat diet as seen in wild-type mice (J:204922)
• mutants on a high-fat diet do not show increased fat depots or enlarged adipocytes as seen in wild-type mice (J:204922)
• mutants do not develop obesity on a high-fat diet as seen in wild-type mice (J:204922)
• mutants on a high-fat diet do not show increased fat depots or enlarged adipocytes as seen in wild-type mice (J:204922)

Mouse Models of Human Disease
OMIM ID Ref(s)
Rheumatoid Arthritis; RA 180300 J:54056




Genotype
MGI:3775436
ht4
Allelic
Composition
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• bilaterial inflammation of the sacroiliac joints occurs starting at 4 weeks of age (J:131930)
• the fibrocartilagenous portion of the joint is invaded by mononuclear cells that protrude into the bone marrow (J:131930)
• bilaterial inflammation of the sacroiliac joints occurs starting at 4 weeks of age (J:131930)
• the fibrocartilagenous portion of the joint is invaded by mononuclear cells that protrude into the bone marrow (J:131930)

skeleton
• bilaterial inflammation of the sacroiliac joints occurs starting at 4 weeks of age (J:131930)
• the fibrocartilagenous portion of the joint is invaded by mononuclear cells that protrude into the bone marrow (J:131930)
• bilaterial inflammation of the sacroiliac joints occurs starting at 4 weeks of age (J:131930)
• the fibrocartilagenous portion of the joint is invaded by mononuclear cells that protrude into the bone marrow (J:131930)




Genotype
MGI:3629514
ht5
Allelic
Composition
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mice display high levels of apoptosis in the ilea at 3 months of age (J:108572)
• mice display high levels of apoptosis in the ilea at 3 months of age (J:108572)

immune system
• inflammatory bowel disease develops between 4-8 weeks of age (J:108572)
• inflammatory bowel disease develops between 4-8 weeks of age (J:108572)
• splenocyte counts past 2 months of age show increases in CD11b+ myeloid cells (J:108572)
• splenocyte counts past 2 months of age show increases in CD11b+ myeloid cells (J:108572)
• there is a significant increase in CD8+ T cell number in Tnftm2Gkl mice past 2 months of age (J:108572)
• there is a significant increase in CD8+ T cell number in Tnftm2Gkl mice past 2 months of age (J:108572)
• mild splenomegaly development correlates with inflammatory bowel disease (IBD) development and becomes significant by 4 months of age (J:108572)
• mild splenomegaly development correlates with inflammatory bowel disease (IBD) development and becomes significant by 4 months of age (J:108572)
• T lymphocytes show a high degree of target cell lysis of syngeneic targets (J:108572)
• in allogeneic mixed lymphocyte reactions, splenocytes show enhanced proliferation compared to wild-type controls (J:108572)
• T lymphocytes show a high degree of target cell lysis of syngeneic targets (J:108572)
• in allogeneic mixed lymphocyte reactions, splenocytes show enhanced proliferation compared to wild-type controls (J:108572)
• when lethality irradiated heterozygotes (that had also received anti-Tnf antibody treatment) receive bone marrow from wild-type mice only display mild villus blunting 9 weeks after removal of antibody treatment (J:108572)
• when lethality irradiated heterozygotes (that had also received anti-Tnf antibody treatment) receive bone marrow from wild-type mice only display mild villus blunting 9 weeks after removal of antibody treatment (J:108572)

hematopoietic system
• splenocyte counts past 2 months of age show increases in CD11b+ myeloid cells (J:108572)
• splenocyte counts past 2 months of age show increases in CD11b+ myeloid cells (J:108572)
• there is a significant increase in CD8+ T cell number in Tnftm2Gkl mice past 2 months of age (J:108572)
• there is a significant increase in CD8+ T cell number in Tnftm2Gkl mice past 2 months of age (J:108572)
• mild splenomegaly development correlates with inflammatory bowel disease (IBD) development and becomes significant by 4 months of age (J:108572)
• mild splenomegaly development correlates with inflammatory bowel disease (IBD) development and becomes significant by 4 months of age (J:108572)
• T lymphocytes show a high degree of target cell lysis of syngeneic targets (J:108572)
• in allogeneic mixed lymphocyte reactions, splenocytes show enhanced proliferation compared to wild-type controls (J:108572)
• T lymphocytes show a high degree of target cell lysis of syngeneic targets (J:108572)
• in allogeneic mixed lymphocyte reactions, splenocytes show enhanced proliferation compared to wild-type controls (J:108572)

digestive/alimentary system
• inflammatory bowel disease develops between 4-8 weeks of age (J:108572)
• inflammatory bowel disease develops between 4-8 weeks of age (J:108572)




Genotype
MGI:3622071
ht6
Allelic
Composition
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * C57BL/6 * SPRET/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at 9 months similar bowel inflammation extending into the mucosal layers and loss of crypt morphology is seen in mice on a mixed background with or without SPRET/Ei (J:92307)
• at 9 months similar bowel inflammation extending into the mucosal layers and loss of crypt morphology is seen in mice on a mixed background with or without SPRET/Ei (J:92307)
• Background Sensitivity: at 9 months arthritis is not severe enough to reduce mobility unlike in mice on a mixed background that does not include SPRET/Ei (J:92307)
• Background Sensitivity: at 9 months arthritis is not severe enough to reduce mobility unlike in mice on a mixed background that does not include SPRET/Ei (J:92307)

digestive/alimentary system
• at 9 months similar bowel inflammation extending into the mucosal layers and loss of crypt morphology is seen in mice on a mixed background with or without SPRET/Ei (J:92307)
• at 9 months similar bowel inflammation extending into the mucosal layers and loss of crypt morphology is seen in mice on a mixed background with or without SPRET/Ei (J:92307)

skeleton
• Background Sensitivity: at 9 months arthritis is not severe enough to reduce mobility unlike in mice on a mixed background that does not include SPRET/Ei (J:92307)
• Background Sensitivity: at 9 months arthritis is not severe enough to reduce mobility unlike in mice on a mixed background that does not include SPRET/Ei (J:92307)

integument
• at 9 months of age (J:92307)
• at 9 months of age (J:92307)




Genotype
MGI:3622062
ht7
Allelic
Composition
Tnftm1Gkl/Tnftm2Gkl
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at 6 weeks of age circulating levels of TNF are up between 90 and 430 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• at 6 weeks of age circulating levels of TNF are up between 90 and 430 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• increased basal and LPS-induced secretion of TNF from thioglycollate-elicited peritoneal macrophages and bone marrow-derived macrophages (J:54056)
• spleen derived T lymphocytes have 3-fold greater TNF production and prolonged mRNA accumulation after incubation with an agonistic anti-CD3 antibody (J:54056)
• splenic B220+ cells also show increased basal and mitogen-stimulated TNF production (J:54056)
• primary synovial and lung fibroblasts display spontaneous TNF secretion and increased secretion following LPS stimulation unlike controls (J:54056)
• increased basal and LPS-induced secretion of TNF from thioglycollate-elicited peritoneal macrophages and bone marrow-derived macrophages (J:54056)
• spleen derived T lymphocytes have 3-fold greater TNF production and prolonged mRNA accumulation after incubation with an agonistic anti-CD3 antibody (J:54056)
• splenic B220+ cells also show increased basal and mitogen-stimulated TNF production (J:54056)
• primary synovial and lung fibroblasts display spontaneous TNF secretion and increased secretion following LPS stimulation unlike controls (J:54056)
• disease onset occurs at 6-8 weeks of age (J:54056)
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction (J:54056)
• both IgM and IgG are detected in arthritic joints (J:54056)
• disease onset occurs at 6-8 weeks of age (J:54056)
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction (J:54056)
• both IgM and IgG are detected in arthritic joints (J:54056)
• increased sensitivity to LPS-induced mortality with 5 of 10 dying after injection of 100 ug/ 25 g compared to complete survival of control mice at the same dose (J:54056)
• increased sensitivity to LPS-induced mortality with 5 of 10 dying after injection of 100 ug/ 25 g compared to complete survival of control mice at the same dose (J:54056)

skeleton
• disease onset occurs at 6-8 weeks of age (J:54056)
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction (J:54056)
• both IgM and IgG are detected in arthritic joints (J:54056)
• disease onset occurs at 6-8 weeks of age (J:54056)
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction (J:54056)
• both IgM and IgG are detected in arthritic joints (J:54056)

homeostasis/metabolism
• at 6 weeks of age circulating levels of TNF are up between 90 and 430 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• at 6 weeks of age circulating levels of TNF are up between 90 and 430 pg/ml compared to undetectable levels in wild-type mice (J:54056)

Mouse Models of Human Disease
OMIM ID Ref(s)
Rheumatoid Arthritis; RA 180300 J:54056




Genotype
MGI:3775437
cn8
Allelic
Composition
Tnftm2Gkl/Tnf+
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(Col6a1-cre)1Gkl/?
Genetic
Background
involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Col6a1-cre)1Gkl mutation (1 available)
Tnfrsf1atm2Gkl mutation (1 available); any Tnfrsf1a mutation (22 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• the ileum contains inflammatory pathology reminiscent of Crohn's disease (J:131930)
• pathology includes blunting of intestinal villi, and infiltration of inflammation cells into the mucosal and submucosal layers (J:131930)
• 100% of mice have disease by 8 weeks of age (J:131930)
• the ileum contains inflammatory pathology reminiscent of Crohn's disease (J:131930)
• pathology includes blunting of intestinal villi, and infiltration of inflammation cells into the mucosal and submucosal layers (J:131930)
• 100% of mice have disease by 8 weeks of age (J:131930)

immune system
• the ileum contains inflammatory pathology reminiscent of Crohn's disease (J:131930)
• pathology includes blunting of intestinal villi, and infiltration of inflammation cells into the mucosal and submucosal layers (J:131930)
• 100% of mice have disease by 8 weeks of age (J:131930)
• the ileum contains inflammatory pathology reminiscent of Crohn's disease (J:131930)
• pathology includes blunting of intestinal villi, and infiltration of inflammation cells into the mucosal and submucosal layers (J:131930)
• 100% of mice have disease by 8 weeks of age (J:131930)
• 100% of mice have arthritis by 8 weeks of age (J:131930)
• joints are infiltrated by mononuclear cells (J:131930)
• mice also develop spondyloarthritis in their sacroiliac joints (J:131930)
• 100% of mice have arthritis by 8 weeks of age (J:131930)
• joints are infiltrated by mononuclear cells (J:131930)
• mice also develop spondyloarthritis in their sacroiliac joints (J:131930)

skeleton
• 100% of mice have arthritis by 8 weeks of age (J:131930)
• joints are infiltrated by mononuclear cells (J:131930)
• mice also develop spondyloarthritis in their sacroiliac joints (J:131930)
• 100% of mice have arthritis by 8 weeks of age (J:131930)
• joints are infiltrated by mononuclear cells (J:131930)
• mice also develop spondyloarthritis in their sacroiliac joints (J:131930)




Genotype
MGI:3622058
cx9
Allelic
Composition
Mapk11tm1Jsca/Mapk11tm1Jsca
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk11tm1Jsca mutation (0 available); any Mapk11 mutation (13 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• onset and severity of inflammation of the terminal ileum are similar to mice heterozygous for the Tnf allele only (J:107771)
• onset and severity of inflammation of the terminal ileum are similar to mice heterozygous for the Tnf allele only (J:107771)
• onset and severity of arthritis are similar to mice heterozygous for the Tnf allele only (J:107771)
• onset and severity of arthritis are similar to mice heterozygous for the Tnf allele only (J:107771)

digestive/alimentary system
• onset and severity of inflammation of the terminal ileum are similar to mice heterozygous for the Tnf allele only (J:107771)
• onset and severity of inflammation of the terminal ileum are similar to mice heterozygous for the Tnf allele only (J:107771)

skeleton
• onset and severity of arthritis are similar to mice heterozygous for the Tnf allele only (J:107771)
• onset and severity of arthritis are similar to mice heterozygous for the Tnf allele only (J:107771)




Genotype
MGI:3622063
cx10
Allelic
Composition
Tnftm2Gkl/Tnftm2Gkl
Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Blt mutation (5 available); any Tnfrsf1a mutation (22 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at 6 weeks of age circulating levels of TNF are 320 +/- 160 pg/ml in disease free mutants compared to undetectable levels in wild-type mice (J:54056)
• however, no signs of arthritis or inflammatory bowel disease are detected (J:54056)
• at 6 weeks of age circulating levels of TNF are 320 +/- 160 pg/ml in disease free mutants compared to undetectable levels in wild-type mice (J:54056)
• however, no signs of arthritis or inflammatory bowel disease are detected (J:54056)
• increased basal and LPS-induced secretion of TNF from thioglycollate-elicited peritoneal macrophages and bone marrow-derived macrophages (J:54056)
• primary synovial and lung fibroblasts display spontaneous TNF secretion and increased secretion following LPS stimulation unlike controls (J:54056)
• increased basal and LPS-induced secretion of TNF from thioglycollate-elicited peritoneal macrophages and bone marrow-derived macrophages (J:54056)
• primary synovial and lung fibroblasts display spontaneous TNF secretion and increased secretion following LPS stimulation unlike controls (J:54056)

homeostasis/metabolism
• at 6 weeks of age circulating levels of TNF are 320 +/- 160 pg/ml in disease free mutants compared to undetectable levels in wild-type mice (J:54056)
• however, no signs of arthritis or inflammatory bowel disease are detected (J:54056)
• at 6 weeks of age circulating levels of TNF are 320 +/- 160 pg/ml in disease free mutants compared to undetectable levels in wild-type mice (J:54056)
• however, no signs of arthritis or inflammatory bowel disease are detected (J:54056)




Genotype
MGI:3629603
cx11
Allelic
Composition
Mapkapk2tm1Mgl/Mapkapk2tm1Mgl
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk2tm1Mgl mutation (0 available); any Mapkapk2 mutation (7 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• increase in mortality from 8 weeks of age onward (J:108572)
• increase in mortality from 8 weeks of age onward (J:108572)

cellular
• mice have fewer apoptotic cells in inflamed ileal tissue compared to Tnftm2Gkl/+ controls (J:108572)
• mice have fewer apoptotic cells in inflamed ileal tissue compared to Tnftm2Gkl/+ controls (J:108572)

immune system
N
• there is no change in CD4+ to CD8+ ratios compared to findings in Tnftm2Gkl/+ single mutants (J:108572)
• there is no change in CD4+ to CD8+ ratios compared to findings in Tnftm2Gkl/+ single mutants (J:108572)
• Tnftm2Gkl phenotype is exacerbated in these mice (J:108572)
• Tnftm2Gkl phenotype is exacerbated in these mice (J:108572)
• IBD is associated with early formation of multiple granulomas (J:108572)
• IBD is associated with early formation of multiple granulomas (J:108572)

digestive/alimentary system
• Tnftm2Gkl phenotype is exacerbated in these mice (J:108572)
• Tnftm2Gkl phenotype is exacerbated in these mice (J:108572)




Genotype
MGI:3629608
cx12
Allelic
Composition
Mapk9tm1Flv/Mapk9tm1Flv
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk9tm1Flv mutation (1 available); any Mapk9 mutation (10 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• mice have significantly higher numbers of apoptotic cells in the ilea compared to lower numbers in the infiltrate indicating a higher rate of apoptosis (J:108572)
• mice have significantly higher numbers of apoptotic cells in the ilea compared to lower numbers in the infiltrate indicating a higher rate of apoptosis (J:108572)

immune system
N
• there is no change in CD4+ to CD8+ ratios compared to findings in Tnftm2Gkl/+ single mutants (J:108572)
• there is no change in CD4+ to CD8+ ratios compared to findings in Tnftm2Gkl/+ single mutants (J:108572)
• there is a delayed onset and significant attenuation of disease (J:108572)
• there is a delayed onset and significant attenuation of disease (J:108572)

digestive/alimentary system
• there is a delayed onset and significant attenuation of disease (J:108572)
• there is a delayed onset and significant attenuation of disease (J:108572)




Genotype
MGI:3629606
cx13
Allelic
Composition
Map3k8tm1Pnt/Map3k8tm1Pnt
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8tm1Pnt mutation (0 available); any Map3k8 mutation (7 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• there is a delayed onset and significant attenuation of disease compared to controls (J:108572)
• there is a delayed onset and significant attenuation of disease compared to controls (J:108572)
• number of CD8+CD44hi T cells is higher than in Tnftm2Gkl/+ controls (J:108572)
• number of CD8+CD44hi T cells is higher than in Tnftm2Gkl/+ controls (J:108572)
• there is a significant increase in numbers of CD4+ and CD8+ cells (J:108572)
• there is a significant increase in numbers of CD4+ and CD8+ cells (J:108572)

hematopoietic system
• number of CD8+CD44hi T cells is higher than in Tnftm2Gkl/+ controls (J:108572)
• number of CD8+CD44hi T cells is higher than in Tnftm2Gkl/+ controls (J:108572)
• there is a significant increase in numbers of CD4+ and CD8+ cells (J:108572)
• there is a significant increase in numbers of CD4+ and CD8+ cells (J:108572)

digestive/alimentary system
• there is a delayed onset and significant attenuation of disease compared to controls (J:108572)
• there is a delayed onset and significant attenuation of disease compared to controls (J:108572)




Genotype
MGI:3629523
cx14
Allelic
Composition
Tcrdtm1Mom/Tcrdtm1Mom
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcrdtm1Mom mutation (13 available); any Tcrd mutation (13 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• development and severity of inflammatory bowel disease are similar to Tnftm2Gkl/+, wild-type B2m controls (J:108572)
• development and severity of inflammatory bowel disease are similar to Tnftm2Gkl/+, wild-type B2m controls (J:108572)

digestive/alimentary system
• development and severity of inflammatory bowel disease are similar to Tnftm2Gkl/+, wild-type B2m controls (J:108572)
• development and severity of inflammatory bowel disease are similar to Tnftm2Gkl/+, wild-type B2m controls (J:108572)




Genotype
MGI:5702939
cx15
Allelic
Composition
Cd44tm1Hbg/Cd44+
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44tm1Hbg mutation (4 available); any Cd44 mutation (31 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• reduced ileitis compared with Tnftm2Gkl heterozygous mice (J:145626)
• reduced ileitis compared with Tnftm2Gkl heterozygous mice (J:145626)

immune system
• reduced ileitis compared with Tnftm2Gkl heterozygous mice (J:145626)
• reduced ileitis compared with Tnftm2Gkl heterozygous mice (J:145626)




Genotype
MGI:5702938
cx16
Allelic
Composition
Cd44tm1Hbg/Cd44tm1Hbg
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd44tm1Hbg mutation (4 available); any Cd44 mutation (31 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
N
• mice exhibit attenuation of ileitis (J:145626)
• mice exhibit attenuation of ileitis (J:145626)

immune system
N
• mice exhibit attenuation of ileitis (J:145626)
• mice exhibit attenuation of ileitis (J:145626)




Genotype
MGI:3629590
cx17
Allelic
Composition
Il12btm1Jm/Il12btm1Jm
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12btm1Jm mutation (3 available); any Il12b mutation (11 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice display delayed development and attenuation of inflammatory bowel disease (J:108572)
• mice display delayed development and attenuation of inflammatory bowel disease (J:108572)

digestive/alimentary system
• mice display delayed development and attenuation of inflammatory bowel disease (J:108572)
• mice display delayed development and attenuation of inflammatory bowel disease (J:108572)




Genotype
MGI:3622064
cx18
Allelic
Composition
Tnftm2Gkl/Tnf+
Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic
Background
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1btm1Mwm mutation (2 available); any Tnfrsf1b mutation (9 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at 1-5 months of age, only mild intestinal inflammation and no signs of transmural inflammation are seen, unlike in mice heterozygous for Tnftm2Gkl only (J:54056)
• at 1-5 months of age, only mild intestinal inflammation and no signs of transmural inflammation are seen, unlike in mice heterozygous for Tnftm2Gkl only (J:54056)
• arthritis is more aggressive and destructive than in mice heterozygous for Tnftm2Gkl only with increased swelling of the joints, synovial hyperplasia, numbers of polymorphonuclear infiltrates, and destruction of bone and cartilage (J:54056)
• arthritis is more aggressive and destructive than in mice heterozygous for Tnftm2Gkl only with increased swelling of the joints, synovial hyperplasia, numbers of polymorphonuclear infiltrates, and destruction of bone and cartilage (J:54056)

digestive/alimentary system
• at 1-5 months of age, only mild intestinal inflammation and no signs of transmural inflammation are seen, unlike in mice heterozygous for Tnftm2Gkl only (J:54056)
• at 1-5 months of age, only mild intestinal inflammation and no signs of transmural inflammation are seen, unlike in mice heterozygous for Tnftm2Gkl only (J:54056)

skeleton
• arthritis is more aggressive and destructive than in mice heterozygous for Tnftm2Gkl only with increased swelling of the joints, synovial hyperplasia, numbers of polymorphonuclear infiltrates, and destruction of bone and cartilage (J:54056)
• arthritis is more aggressive and destructive than in mice heterozygous for Tnftm2Gkl only with increased swelling of the joints, synovial hyperplasia, numbers of polymorphonuclear infiltrates, and destruction of bone and cartilage (J:54056)




Genotype
MGI:3799634
cx19
Allelic
Composition
Ccr9tm1.1Mal/Ccr9tm1.1Mal
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr9tm1.1Mal mutation (0 available); any Ccr9 mutation (3 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles (J:136667)
• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles (J:136667)
• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles (J:136667)
• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles (J:136667)
• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnftm2Gkl alone (J:136667)
• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnftm2Gkl alone (J:136667)
• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnftm2Gkl alone (J:136667)
• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnftm2Gkl alone (J:136667)
• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnftm2Gkl alone (J:136667)
• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnftm2Gkl alone (J:136667)

digestive/alimentary system
• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles (J:136667)
• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles (J:136667)
• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles (J:136667)
• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles (J:136667)

hematopoietic system
• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnftm2Gkl alone (J:136667)
• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnftm2Gkl alone (J:136667)
• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnftm2Gkl alone (J:136667)
• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnftm2Gkl alone (J:136667)
• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnftm2Gkl alone (J:136667)
• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnftm2Gkl alone (J:136667)




Genotype
MGI:3799633
cx20
Allelic
Composition
Ccl25tm1Mal/Ccl25tm1Mal
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl25tm1Mal mutation (1 available); any Ccl25 mutation (29 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles (J:136667)
• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles (J:136667)
• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles (J:136667)
• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles (J:136667)
• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnftm2Gkl alone (J:136667)
• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnftm2Gkl alone (J:136667)
• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnftm2Gkl alone (J:136667)
• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnftm2Gkl alone (J:136667)
• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnftm2Gkl alone (J:136667)
• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnftm2Gkl alone (J:136667)

digestive/alimentary system
• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles (J:136667)
• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles (J:136667)
• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles (J:136667)
• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles (J:136667)

hematopoietic system
• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnftm2Gkl alone (J:136667)
• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnftm2Gkl alone (J:136667)
• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnftm2Gkl alone (J:136667)
• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnftm2Gkl alone (J:136667)
• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnftm2Gkl alone (J:136667)
• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnftm2Gkl alone (J:136667)




Genotype
MGI:3629519
cx21
Allelic
Composition
Ighmtm1Cgn/Ighmtm1Cgn
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (19 available); any Ighm mutation (26 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• development and severity of inflammatory bowel disease are similar to Tnftm2Gkl/+, wild-type B2m controls (J:108572)
• development and severity of inflammatory bowel disease are similar to Tnftm2Gkl/+, wild-type B2m controls (J:108572)

digestive/alimentary system
• development and severity of inflammatory bowel disease are similar to Tnftm2Gkl/+, wild-type B2m controls (J:108572)
• development and severity of inflammatory bowel disease are similar to Tnftm2Gkl/+, wild-type B2m controls (J:108572)




Genotype
MGI:3629516
cx22
Allelic
Composition
Cd4tm1Mak/Cd4tm1Mak
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Mak mutation (3 available); any Cd4 mutation (43 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• there is high incidence of mortality in mice by age of 2-3 months (J:108572)
• there is high incidence of mortality in mice by age of 2-3 months (J:108572)

immune system
• mice show exacerbation of IBD compared to Tnftm2Gkl/+ mice (J:108572)
• mice show exacerbation of IBD compared to Tnftm2Gkl/+ mice (J:108572)

digestive/alimentary system
• mice show exacerbation of IBD compared to Tnftm2Gkl/+ mice (J:108572)
• mice show exacerbation of IBD compared to Tnftm2Gkl/+ mice (J:108572)




Genotype
MGI:3629515
cx23
Allelic
Composition
B2mtm1Jae/B2mtm1Jae
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Jae mutation (4 available); any B2m mutation (45 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice display delayed development and attenuation of inflammatory bowel disease (J:108572)
• mice display delayed development and attenuation of inflammatory bowel disease (J:108572)

digestive/alimentary system
• mice display delayed development and attenuation of inflammatory bowel disease (J:108572)
• mice display delayed development and attenuation of inflammatory bowel disease (J:108572)




Genotype
MGI:3622066
cx24
Allelic
Composition
Rag1tm1Mom/Rag1tm1Mom
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (27 available); any Rag1 mutation (45 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• only minimal intestinal inflammation is seen, unlike in mice heterozygous for Tnftm2Gkl only (J:54056)
• only minimal intestinal inflammation is seen, unlike in mice heterozygous for Tnftm2Gkl only (J:54056)
• arthritis is similar to mice heterozygous for Tnftm2Gkl only (J:54056)
• arthritis is similar to mice heterozygous for Tnftm2Gkl only (J:54056)

digestive/alimentary system
• only minimal intestinal inflammation is seen, unlike in mice heterozygous for Tnftm2Gkl only (J:54056)
• only minimal intestinal inflammation is seen, unlike in mice heterozygous for Tnftm2Gkl only (J:54056)

skeleton
• arthritis is similar to mice heterozygous for Tnftm2Gkl only (J:54056)
• arthritis is similar to mice heterozygous for Tnftm2Gkl only (J:54056)




Genotype
MGI:3629594
cx25
Allelic
Composition
Ifngtm1Ts/Ifngtm1Ts
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (14 available); any Ifng mutation (26 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• development and severity of IBD are similar to Tnftm2Gkl/+, wild-type Ifng controls (J:108572)
• development and severity of IBD are similar to Tnftm2Gkl/+, wild-type Ifng controls (J:108572)

digestive/alimentary system
• development and severity of IBD are similar to Tnftm2Gkl/+, wild-type Ifng controls (J:108572)
• development and severity of IBD are similar to Tnftm2Gkl/+, wild-type Ifng controls (J:108572)




Genotype
MGI:3799636
cx26
Allelic
Composition
Itgb7tm1Cgn/Itgb7tm1Cgn
Tnftm2Gkl/Tnf+
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb7tm1Cgn mutation (3 available); any Itgb7 mutation (33 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• significant attenuation of the inflammatory bowel disease pathology with reduced acute and chronic inflammatory indices relative to mice heterozygous for Tnftm2Gkl alone (J:136667)
• significant attenuation of the inflammatory bowel disease pathology with reduced acute and chronic inflammatory indices relative to mice heterozygous for Tnftm2Gkl alone (J:136667)
• chronic inflammatory arthritis is similar to mice heterozygous for Tnftm2Gkl alone (J:136667)
• chronic inflammatory arthritis is similar to mice heterozygous for Tnftm2Gkl alone (J:136667)

skeleton
• chronic inflammatory arthritis is similar to mice heterozygous for Tnftm2Gkl alone (J:136667)
• chronic inflammatory arthritis is similar to mice heterozygous for Tnftm2Gkl alone (J:136667)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory