Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation
(0 available);
any
Pik3cd mutation
(43 available)
|
|
|
hematopoietic system
|
|
• platelets exhibit slower shape change and decreased rate and amplitude of aggregation compared to wild-type platelets in response to submaximal concentrations of adenosine diphosphate or phorbol ester, or intermediate and high levels of collagen-related peptide
|
homeostasis/metabolism
immune system
|
|
• mice exhibit a 45% to 53% decrease in paw edema, reduced synovial inflammation, and reduced bone and cartilage erosion following administration of arthritogenic serum compared to wild-type mice
|
|
|
• mice exhibit a 45% to 53% decrease in paw edema, reduced synovial inflammation, and reduced bone and cartilage erosion following administration of arthritogenic serum compared to wild-type mice
• however, neutrophil migration in response to fMLP is normal
|
skeleton
|
|
• mice exhibit a 45% to 53% decrease in paw edema, reduced synovial inflammation, and reduced bone and cartilage erosion following administration of arthritogenic serum compared to wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation
(0 available);
any
Pik3cd mutation
(43 available)
|
|
|
immune system
|
|
• splenic B220+ CDhi B cells are absent unlike in wild-type mice
|
|
|
• B1 B cells in the peritoneal cavity are decreased compared to in wild-type mice
|
|
|
• the number of B2 B cells is significantly reduced in young mice and marginally reduced in older mice compared to in wild-type mice of the same age
|
|
|
• CD21hi CD23lo marginal zone B cells are reduced in number in the spleen compared to in wild-type mice
|
|
|
• entry into the cell cycle and, by consequence proliferation, of B cells in response to anti-IgM antibodies is delayed compared to in wild-type mice
• in response to treatment with anti-IgM antibodies, apoptosis of B cells increased unlike in wild-type mice
|
|
|
• in response to anti-IgM, CD40 and IL-4
(J:79133)
• however, B cell proliferation response to LPS is normal
(J:79133)
|
|
|
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG1 than in wild-type mice
|
|
|
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG2a than in wild-type mice
|
|
|
• following stimulation with DNP-Ficoll, mice produce less IgG2b than wild-type mice
|
|
|
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG3 than in wild-type mice
|
|
|
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgM than in wild-type mice
|
|
|
• following immunization with DNP-Ficoll, mice produce less IgG3 than in wild-type mice
|
hematopoietic system
|
|
• splenic B220+ CDhi B cells are absent unlike in wild-type mice
|
|
|
• B1 B cells in the peritoneal cavity are decreased compared to in wild-type mice
|
|
|
• the number of B2 B cells is significantly reduced in young mice and marginally reduced in older mice compared to in wild-type mice of the same age
|
|
|
• CD21hi CD23lo marginal zone B cells are reduced in number in the spleen compared to in wild-type mice
|
|
|
• entry into the cell cycle and, by consequence proliferation, of B cells in response to anti-IgM antibodies is delayed compared to in wild-type mice
• in response to treatment with anti-IgM antibodies, apoptosis of B cells increased unlike in wild-type mice
|
|
|
• in response to anti-IgM, CD40 and IL-4
(J:79133)
• however, B cell proliferation response to LPS is normal
(J:79133)
|
|
|
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG1 than in wild-type mice
|
|
|
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG2a than in wild-type mice
|
|
|
• following stimulation with DNP-Ficoll, mice produce less IgG2b than wild-type mice
|
|
|
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgG3 than in wild-type mice
|
|
|
• whether non-immunized or following immunization with DNP-Ficoll, mice produce less IgM than in wild-type mice
|
cellular
|
|
• in response to anti-IgM, CD40 and IL-4
(J:79133)
• however, B cell proliferation response to LPS is normal
(J:79133)
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation
(11 available);
any
Cd19 mutation
(56 available)
Pik3cdtm1Tnr mutation
(0 available);
any
Pik3cd mutation
(43 available)
Ptentm2.1Ppp mutation
(0 available);
any
Pten mutation
(81 available)
|
|
|
immune system
|
N |
• unlike in Pten deficient mice, B1 B cell numbers are normal in the spleen and peritoneum
|
|
|
• defects in class switch recombination associated with Pten deficiency are partially reversed
|
|
|
• mice exhibit an increase in marginal zone B cells that is not as great as in Pten null mice but more than in wild-type mice
|
hematopoietic system
|
|
• defects in class switch recombination associated with Pten deficiency are partially reversed
|
|
|
• mice exhibit an increase in marginal zone B cells that is not as great as in Pten null mice but more than in wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation
(0 available);
any
Pik3cd mutation
(43 available)
Pik3cgtm1Pngr mutation
(0 available);
any
Pik3cg mutation
(59 available)
|
|
|
immune system
|
|
• neutrophil migration in a chemotaxis assay with LB4 or fMLP stimulation is reduced compared to for wild-type cells
• neutrophils travel shorter distances and at slower velocities than wild-type cells
|
|
|
• neutrophils accumulation following LTB4-stimulation is reduced greater than 70% compared to in wild-type mice
|
|
|
• following administration of arthritogenic serum, mice develop minimal swelling unlike in wild-type mice
• 14 days following administration of autoreactive antibodies, mice exhibit relatively normal articular surfaces, intact joint spaces and the absence of periaticular inflammation unlike wild-type mice
|
|
|
• following administration of arthritogenic serum, mice develop minimal swelling unlike in wild-type mice
• 14 days following administration of autoreactive antibodies, mice exhibit relatively normal articular surfaces, intact joint spaces and the absence of periaticular inflammation unlike wild-type mice
|
skeleton
|
|
• following administration of arthritogenic serum, mice develop minimal swelling unlike in wild-type mice
• 14 days following administration of autoreactive antibodies, mice exhibit relatively normal articular surfaces, intact joint spaces and the absence of periaticular inflammation unlike wild-type mice
|
cellular
|
|
• neutrophil migration in a chemotaxis assay with LB4 or fMLP stimulation is reduced compared to for wild-type cells
• neutrophils travel shorter distances and at slower velocities than wild-type cells
|
hematopoietic system
|
|
• neutrophil migration in a chemotaxis assay with LB4 or fMLP stimulation is reduced compared to for wild-type cells
• neutrophils travel shorter distances and at slower velocities than wild-type cells
|
|
|
• neutrophils accumulation following LTB4-stimulation is reduced greater than 70% compared to in wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation
(0 available);
any
Pik3cd mutation
(43 available)
Pik3cgtm1Pngr mutation
(0 available);
any
Pik3cg mutation
(59 available)
|
|
|
immune system
|
|
• corticomedullary differentiation is lost
|
|
|
• total thymus cell count is reduced 27-fold compared to in wild-type mice and 10-fold compared to in Pik3cg null mice
|
|
|
• the population of DN3 T cells is phenotypically different from in wild-type mice due to altered marker expression
|
|
|
• peripheral lymph nodes and spleen exhibit decreased T cell populations compared to in wild-type mice
|
|
|
• mice have fewer double positive T cells due to increased apoptosis compared to in wild-type mice
|
|
|
• calcium fluxes in response to TCR cross-linking are absent from T cells unlike in wild-type cells
|
hematopoietic system
|
|
• corticomedullary differentiation is lost
|
|
|
• total thymus cell count is reduced 27-fold compared to in wild-type mice and 10-fold compared to in Pik3cg null mice
|
|
|
• the population of DN3 T cells is phenotypically different from in wild-type mice due to altered marker expression
|
|
|
• peripheral lymph nodes and spleen exhibit decreased T cell populations compared to in wild-type mice
|
|
|
• mice have fewer double positive T cells due to increased apoptosis compared to in wild-type mice
|
|
|
• calcium fluxes in response to TCR cross-linking are absent from T cells unlike in wild-type cells
|
endocrine/exocrine glands
|
|
• corticomedullary differentiation is lost
|
|
|
• total thymus cell count is reduced 27-fold compared to in wild-type mice and 10-fold compared to in Pik3cg null mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cdtm1Tnr mutation
(0 available);
any
Pik3cd mutation
(43 available)
Tg(BCL2)36Wehi mutation
(3 available)
|
|
|
immune system
|
|
• the decrease in the number of follicular B cells is not corrected by the presence of the transgene
|
hematopoietic system
|
|
• the decrease in the number of follicular B cells is not corrected by the presence of the transgene
|
Analysis Tools