All Phenotypes Mdm4<tm1Glo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mdm4^tm1Glo
targeted mutation 1, Guillermina Lozano
MGI:2183485

Summary

13 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mdm4^tm1Glo/Mdm4^tm1Glo	Not Specified	MGI:3850678
ht2	Mdm4^tm1Glo/Mdm4⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:3850698
ht3	Mdm4^tm1Glo/Mdm4⁺	Not Specified	MGI:5140382
cx4	Mdm4^tm1Glo/Mdm4^tm1Glo Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas	MGI:3850680
cx5	Mdm4^tm1Glo/Mdm4^tm1Glo Trp53^tm1Tyj/Trp53⁺	involves: 129S2/SvPas	MGI:3850686
cx6	Mdm2^tm1Glo/Mdm2⁺ Mdm4^tm1Glo/Mdm4⁺ Trp53^tm1Tyj/Trp53⁺	involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	MGI:3850704
cx7	Mdm4^tm1Glo/Mdm4⁺ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6	MGI:3850700
cx8	Mdm4^tm1Glo/Mdm4⁺ Trp53^tm1.1Tldo/Trp53⁺	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:5524025
cx9	Mdm4^tm1Glo/Mdm4^tm1Glo Trp53^tm1Adv/Trp53^tm1Adv	involves: 129S4/SvJae	MGI:3850684
cx10	Mdm2^tm1Glo/Mdm2⁺ Mdm4^tm1Glo/Mdm4⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6	MGI:3850703
cx11	Mdm4^tm1Glo/Mdm4⁺ Tg(IghMyc)22Bri/0	involves: 129S6/SvEvTac * C57BL * C57BL/6 * SJL	MGI:3850699
cx12	Mdm2^tm1Glo/Mdm2⁺ Mdm4^tm1Glo/Mdm4⁺	involves: 129S7/SvEvBrd	MGI:3850681
cx13	Mdm4^tm1Glo/Mdm4⁺ Rpl27a^Sfa/Rpl27a⁺	involves: C57BL/6J	MGI:5140362

Allelic Composition	Mdm4^tm1Glo/Mdm4^tm1Glo
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm1Glo mutation (0 available); any Mdm4 mutation (191 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:71532 )

• mice die as early as E7.5

cellular

decreased cell proliferation ( J:71532 )

• at E7.5, embryos exhibit decreased cellular proliferation compared with wild-type embryos without an increase in apoptosis

Allelic Composition	Mdm4^tm1Glo/Mdm4⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm1Glo mutation (0 available); any Mdm4 mutation (191 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased mortality induced by ionizing radiation ( J:123661 )

• mice treated with ionizing radiation exhibit increased mortality compared with similarly treated wild-type mice and Mdm2^tm1Glo heterozygotes

cellular

abnormal cell physiology ( J:123661 )

• following transformation with c-myc and activated Ras oncogenes, mouse embryonic fibroblasts exhibit 33% fewer foci compared with wild-type cells

homeostasis/metabolism

increased mortality induced by ionizing radiation ( J:123661 )

• mice treated with ionizing radiation exhibit increased mortality compared with similarly treated wild-type mice and Mdm2^tm1Glo heterozygotes

Allelic Composition	Mdm4^tm1Glo/Mdm4⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm1Glo mutation (0 available); any Mdm4 mutation (191 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased mortality induced by ionizing radiation ( J:174368 )

• 65% of mice die after exposure to 6 Gy of ionizing radiation

pigmentation

increased foot pad pigmentation ( J:174216 )

• starting around 3 - 4 weeks of age

integument

increased foot pad pigmentation ( J:174216 )

• starting around 3 - 4 weeks of age

limbs/digits/tail

increased foot pad pigmentation ( J:174216 )

• starting around 3 - 4 weeks of age

homeostasis/metabolism

increased mortality induced by ionizing radiation ( J:174368 )

• 65% of mice die after exposure to 6 Gy of ionizing radiation

Allelic Composition	Mdm4^tm1Glo/Mdm4^tm1Glo Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm1Glo mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:71532 , J:93838 )

N	• mice are born in expected Mendelian ratios (J:71532) • mice are born in expected Mendelian ratios (J:93838)

Allelic Composition	Mdm4^tm1Glo/Mdm4^tm1Glo Trp53^tm1Tyj/Trp53⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:93838 )

• no mice are present at 3 weeks of age

embryo

abnormal embryo development ( J:93838 )

• embryos are abnormal at E9.5

Allelic Composition	Mdm2^tm1Glo/Mdm2⁺ Mdm4^tm1Glo/Mdm4⁺ Trp53^tm1Tyj/Trp53⁺
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2^tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Mdm4^tm1Glo mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:123661 )

N	• mice are born in expected Mendelian ratios

Allelic Composition	Mdm4^tm1Glo/Mdm4⁺ Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:123661 )

N	• mice exhibit normal mortality in response to treatment with ionizing radiation

Allelic Composition	Mdm4^tm1Glo/Mdm4⁺ Trp53^tm1.1Tldo/Trp53⁺
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm1Glo mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm1.1Tldo mutation (0 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:199308 )

• most die within 3 months

hematopoietic system

decreased bone marrow cell number ( J:199308 )

• decreased compared to Trp53^tm1.1Tldo/+ mice

cellular

decreased telomere length ( J:199308 )

• decreased compared to Trp53^tm1.1Tldo/+ mice

Allelic Composition	Mdm4^tm1Glo/Mdm4^tm1Glo Trp53^tm1Adv/Trp53^tm1Adv
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm1Glo mutation (0 available); any Mdm4 mutation (191 available)
Trp53^tm1Adv mutation (1 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:93838 )

• no mice are present at 3 weeks of age

embryo

abnormal embryo development ( J:93838 )

• embryos are abnormal at E9.5

embryonic growth retardation ( J:93838 )

• at E9.5

growth/size/body

embryonic growth retardation ( J:93838 )

• at E9.5

Allelic Composition	Mdm2^tm1Glo/Mdm2⁺ Mdm4^tm1Glo/Mdm4⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:123661 )

• no mice are present at weaning

prenatal lethality, incomplete penetrance ( J:123661 )

• fewer than expected mice are born

hematopoietic system

thymus atrophy ( J:123661 )

thymus hypoplasia ( J:123661 )

abnormal definitive hematopoiesis ( J:123661 )

• mice exhibit decreased extramedullary hematopoiesis in the liver

anemia ( J:123661 )

• at birth

decreased bone marrow cell number ( J:123661 )

decreased erythrocyte cell number ( J:123661 )

decreased hemoglobin content ( J:123661 )

thrombocytopenia ( J:123661 )

decreased leukocyte cell number ( J:123661 )

pancytopenia ( J:123661 )

spleen atrophy ( J:123661 )

spleen hypoplasia ( J:123661 )

nervous system

abnormal cerebellum external granule cell layer morphology ( J:123661 )

• hypoplastic

abnormal Purkinje cell morphology ( J:123661 )

• disorganized

abnormal cerebellar granule layer morphology ( J:123661 )

• the granule layer of the cerebellum is hypoplastic with defects in both the external granule layer and the internal granule layer

cerebellum hypoplasia ( J:123661 )

exencephaly ( J:123661 )

• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails

growth/size/body

cleft palate ( J:123661 )

• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails

decreased embryo size ( J:123661 )

• mid-gestation

decreased body weight ( J:123661 )

decreased fetal size ( J:123661 )

• mice are smaller than normal at birth

cellular

abnormal cell physiology ( J:123661 )

• following transformation with c-myc and activated Ras oncogenes, mouse embryonic fibroblasts exhibit fewer foci compared with wild-type or single heterozygote cells

increased embryonic tissue cell apoptosis ( J:123661 )

• in E13.5 embryos

renal/urinary system

decreased renal glomerulus number ( J:123661 )

• fewer and smaller

craniofacial

cleft palate ( J:123661 )

• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails

limbs/digits/tail

kinked tail ( J:123661 )

• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails

immune system

thymus atrophy ( J:123661 )

thymus hypoplasia ( J:123661 )

decreased leukocyte cell number ( J:123661 )

spleen atrophy ( J:123661 )

spleen hypoplasia ( J:123661 )

embryo

increased embryonic tissue cell apoptosis ( J:123661 )

• in E13.5 embryos

decreased embryo size ( J:123661 )

• mid-gestation

digestive/alimentary system

cleft palate ( J:123661 )

• 10% to 20% of mice exhibit exencephaly associated with cleft palate, or other types of neural tube closure defects, such as kinked tails

integument

pallor ( J:123661 )

• embryos are pale mid-gestation

endocrine/exocrine glands

thymus atrophy ( J:123661 )

thymus hypoplasia ( J:123661 )

Allelic Composition	Mdm4^tm1Glo/Mdm4⁺ Tg(IghMyc)22Bri/0
Genetic Background	involves: 129S6/SvEvTac * C57BL * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm1Glo mutation (0 available); any Mdm4 mutation (191 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased B cell derived lymphoma incidence ( J:123661 )

• mice develop B cell lymphomas

• however, lymphomagenesis is delayed compared to in Tg(IghMyc)22Bri mice

Allelic Composition	Mdm2^tm1Glo/Mdm2⁺ Mdm4^tm1Glo/Mdm4⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:71532 )

N	• mice are born in expected Mendelian ratios

hematopoietic system

anemia ( J:174216 )

• bone marrow sections show hypocellularity indicative of aplastic anemia

decreased bone marrow cell number ( J:174216 )

• bone marrow sections show hypocellularity indicative of aplastic anemia

nervous system

abnormal Purkinje cell morphology ( J:174216 )

• distribution of Purkinje neurons is disorganized in the cerebellum

decreased cerebellar granule cell number ( J:174216 )

small cerebellum ( J:174216 )

pigmentation

increased foot pad pigmentation ( J:174216 )

• detectable first at P4

integument

increased foot pad pigmentation ( J:174216 )

• detectable first at P4

limbs/digits/tail

increased foot pad pigmentation ( J:174216 )

• detectable first at P4

Allelic Composition	Mdm4^tm1Glo/Mdm4⁺ Rpl27a^Sfa/Rpl27a⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4^tm1Glo mutation (0 available); any Mdm4 mutation (191 available)
Rpl27a^Sfa mutation (0 available); any Rpl27a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:174216 )

• no pups are born

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